Disruption of the linear relationship between recognition memory and local functional connectivity of left perirhinal cortex in rat after acute 2.856 GHz microwave exposure.

Objective: With the widespread utilization of S band (2 GHz ∼ 4 GHz) microwave (MW) in communication, its potential health risks have drawn significant attention. The purpose of this study was to investigate the impacts of acute 2.856 GHz MW exposure on recognition memory, its corresponding functional brain network, and the relationships between them in rats.

Alterations in the Temporal Variation and Spatial Distribution of Blood-Brain Barrier Permeability Following Electromagnetic Pulse Radiation: A Study Based on Dynamic Contrast-Enhanced MRI.

Background: Previous studies have suggested that electromagnetic pulse (EMP) can induce openings in the blood-brain barrier (BBB). However, the temporal variation and spatial distribution of BBB permeability after EMP radiation are difficult to assess using conventional histopathological approaches. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a valuable tool for the in vivo evaluation of BBB permeability.

Interpretable machine learning insights into the association between PFAS exposure and diabetes mellitus.

Background: Diabetes Mellitus (DM) is a global health concern with rising prevalence, and its link to PFAS exposure remains unclear. No machine learning (ML) models have yet been developed to predict DM based on PFAS exposure.

Methods: We analyzed data from 10471 participants in National Health and Nutrition Examination Survey (NHANES, 2003-2018).

Exploring the relationship between per- and polyfluoroalkyl substances exposure and rheumatoid arthritis risk using interpretable machine learning.

Background: Rheumatoid arthritis is a chronic autoimmune disease influenced by environmental exposures, including per- and polyfluoroalkyl substances (PFAS). Although previous studies have suggested links between PFAS and rheumatoid arthritis risk, none have used interpretable machine learning models for prediction. This study aimed to develop such a model to assess risk based on PFAS exposure.

Microwave exposure induced ferroptosis by inhibiting the Nrf2 pathway and affected reproductive function in male mice.

The mechanisms underlying the negative health effects of microwave exposure on male reproduction remain unclear. Thus, this study aimed to explore the role and regulatory mechanisms of ferroptosis in microwave-induced reproductive damage. The exposure of male C57 mice to 2.

Harnessing cell size to separate genetically and functionally distinct dental pulp-derived mesenchymal stromal cell subpopulations.

Background: Dental pulp-derived mesenchymal stromal cells (DPMSCs) represent a promising avenue for regenerative medicine. However, the therapeutic potency of DPMSCs is substantially influenced by their functional heterogeneity emerging during ex vivo expansion. Therefore, identifying and selecting the most potent subpopulation of DPMSCs following expansion is key to improving therapeutic efficacy and consistency.

Experimental Study on Viscosity-Reducing Foam Flooding in Fractured-Vuggy Reservoirs.

The crude oil reserves of fractured-vuggy reservoirs are large, but most of them are heavy oil and ultraheavy oil reservoirs. They have the characteristics of high heavy metal ion concentration, high asphaltene content, high viscosity and density, and deep burial. They are difficult to exploit.

LRRK2 Mediates α-Synuclein-Induced Neuroinflammation and Ferroptosis through the p62-Keap1-Nrf2 Pathway in Parkinson's Disease.

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta and the abnormal aggregation of α-synuclein (α-syn). Despite extensive research, the mechanisms underlying microglial-mediated neuroinflammation and ferroptosis in PD remain inadequately understood. In particular, the role of leucine-rich repeat kinase 2 (LRRK2) in microglial cells and its modulation of the p62-Keap1-Nrf2 signaling pathway warrant further investigation.

Association of hemoglobin-to-red blood cell distribution width ratio with mortality in critically Ill patients with heart failure and acute kidney injury: insights from the MIMIC-IV database.

Background: The association between the hemoglobin-to-red cell distribution width ratio (HRR) and mortality in critically ill patients with heart failure (HF) and acute kidney injury (AKI) remains uncertain. This research focuses on exploring the association between HRR and both short-term and long-term all-cause mortality in these patients.

Methods: Participants were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database and categorized into tertiles based on HRR values.

THz Waves Improve Spatial Working Memory by Increasing the Activity of Glutamatergic Neurons in Mice.

Terahertz (THz) waves, a novel type of radiation with quantum and electronic properties, have attracted increasing attention for their effects on the nervous system. Spatial working memory, a critical component of higher cognitive function, is coordinated by brain regions such as the infralimbic cortex (IL) region of the medial prefrontal cortex and the ventral cornu ammonis 1 (vCA1) of hippocampus. However, the regulatory effects of THz waves on spatial working memory and the underlying mechanisms remain unclear.

Microenvironment-Regulated Hydrogels Prepared with a Brand-New Small Molecule Cross-Linker for Stepwise Treatment of Myocardial Infarction.

Despite the development of many injectable hydrogels intended for the repair of myocardial infarction (MI), their effectiveness is often compromised because they target merely one or two phases of MI's pathological progression. Here, a multifunctional hydrogel delivery platform is prepared with a brand-new small molecule cross-linker for stepwise treatment of MI. The synthesis and reporting of a novel small-molecule phenylboronic acid cross-linker ((N(BA))) with a precise molecular structure is conducted for the first time, and it is successfully utilized with polyvinyl alcohol (PVA) dopamine to prepare a hydrogel with infarct microenvironmental responsiveness and anti-oxidant.

The antimicrobial activity of linezolid against unconventional pathogens.

Linezolid is an oxazolidinone antibiotic that is mainly permitted to treat Gram-positive bacterial infections. Recent studies have shown that linezolid also has antibacterial effects on several other bacteria outside the package insert, including , non-tuberculous mycobacteria (NTM), , , and anaerobes, . Interestingly, linezolid also has an inhibitory effect on fungi.

Impact of Microwave Exposure on Cynomolgus Monkeys: EEG and ECG Analysis.

The annual increase of microwave exposure in human environments continues to fuel debates regarding its potential health impacts. This study monitored the EEG and ECG responses of three Cynomolgus monkeys before and at 0, 3, 7, 14, and 30 days after exposure to 50 mW/cm² microwave radiation for 15 min. The findings revealed no significant differences in the power spectral densities (PSDs) of the whole brain, frontal, and temporal lobes across various frequency bands (δ, θ, α, β, low-γ, and high-γ) immediately and up to 30 days postexposure.

Compound exposure of 2.8 GHz and 9.3 GHz microwave causes learning and memory impairment in rats.

The anxieties and concerns about health hazards caused by microwave has been growing recently. Previous studies have reported microwave induced structural and functional injuries to brain. However, the biological effects caused by compound microwave were largely unexplored.

Characterization and genomic insights into bacteriophages Kpph1 and Kpph9 against hypervirulent carbapenem-resistant .

The increasing incidence of infections attributed to hypervirulent carbapenem-resistant (Hv-CRKp) is of considerable concern. Bacteriophages, also known as phages, are viruses that specifically infect bacteria; thus, phage-based therapies offer promising alternatives to antibiotic treatments targeting Hv-CRKp infections. In this study, two isolated bacteriophages, Kpph1 and Kpph9, were characterized for their specificity against the Hv-CRKp NUHL30457 strain that possesses a K2 capsule serotype.

Development of a urine-based metabolomics approach for multi-cancer screening and tumor origin prediction.

Background: Cancer remains a leading cause of mortality worldwide. A non-invasive screening solution was required for early diagnosis of cancer. Multi-cancer early detection (MCED) tests have been considered to address the challenge by simultaneously identifying multiple types of cancer within a single test using minimally invasive blood samples.

Oxidative stress and energy metabolism in male reproductive damage from single and combined high-power microwave exposure at 1.5 and 4.3GHz.

The effect of multi-frequency electromagnetic environments on male reproduction has attracted the medical community's interest. Studies have investigated the effects and mechanisms of single-frequency microwave exposure on male reproduction, but comparative research on high-power microwave (HPM) composite and single exposure remains scarce. This study aimed to examine the effects and mechanisms of combined 1.

R-loop formation contributes to mTORC1 activation-dependent DNA replication stress induced by p53 deficiency.

DNA replication stress is a significant contributor to spontaneous DNA damage and genome instability. While the impact of p53 deficiency on increasing DNA replication stress is known, the specific molecular mechanism underlying this phenomenon remains poorly understood. This study explores how p53 deficiency induces DNA replication stress by activating mTORC1 through R-loop formation, which is facilitated by the upregulation of RNR.

MicroRNA-450b-5p modulated RPLP0 promotes hepatocellular carcinoma progression via activating JAK/STAT3 pathway.

Hepatocellular carcinoma (HCC) is distinguished by its insidious onset, difficult treatment, and poor prognosis. Ribosomal Protein Lateral Stalk Subunit P0 (RPLP0) is implicated in numerous tumor progression processes. Nevertheless, the regulatory mechanism of RPLP0 in HCC progression remains unclear.

EGFR mutations and abnormal trafficking in cancers.

Epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor and a member of the ErbB receptor family. As a significant cancer driver, EGFR undergoes mutations such as gene amplification or overexpression in a wide range of malignant tumors and is closely associated with tumorigenesis. This review examines the aberrant expression of EGFR in several common cancers and summarizes the current therapeutic strategies developed for this receptor.

Microwave Radiation Caused Dynamic Metabolic Fluctuations in the Mammalian Hippocampus.

To investigate the dynamic changes in hippocampal metabolism after microwave radiation using liquid chromatography in tandem with mass spectrometry/mass spectrometry (LC-MS/MS) and to identify potential biomarkers. Wistar rats were randomly assigned to a sham group and a microwave radiation group. The rats in the microwave radiation group were exposed to 2.

Unlocking the full potential of mesenchymal stromal cell therapy for osteoarthritis through machine learning-based in silico trials.

Despite the potential of mesenchymal stromal cells (MSCs) in osteoarthritis (OA) treatment, the challenge lies in addressing their therapeutic inconsistency. Clinical trials revealed significantly varied therapeutic outcomes among patients receiving the same allogenic MSCs but different treatment regimens. Therefore, optimizing personalized treatment strategies is crucial to fully unlock MSCs' potential and enhance therapeutic consistency.

Combined treatment with cetuximab and STA9090 has synergistic anticancer effects on human non-small cell lung cancer.

Cetuximab (CET), a human murine chimeric IgG monoclonal antibody and an inhibitor of epidermal growth factor receptor (EGFR), has been shown to be effective in treating various types of cancer. However, its use is hindered by limitations such as resistance development, variability in patient response, side effects, and challenges in biomarker identification. Therefore, CET is often combined with other targeted therapies or chemotherapies to enhance its effectiveness.

Mechanism of Microwave Radiation-Induced Learning and Memory Impairment Based on Hippocampal Metabolomics.

The brain is complex and metabolically active, and the detection of metabolites plays an important role in brain development and diseases. Currently, there is a lack of research on the metabolic spectrum changes in learning and memory impairment, and hippocampal damage induced by microwave radiation from the metabolic perspective. Aiming to provide sensitive indicators for microwave radiation-induced brain damage and establish a foundation for understanding its injury mechanisms, this study employed non-targeted metabolomics to investigate metabolic fluctuations and key metabolic pathway alterations in rats' hippocampal tissue after microwave radiation.