Peptide/Protein Functionalization and Macrocyclization via Alkyne Umpolung with Hypervalent Iodine Reagents.

ConspectusAlkynes are one of the most fundamental functional groups in organic synthesis due to the versatile chemistry of the triple bond, their unique rigid structure, and their use in bioconjugation. The introduction of alkynes onto organic molecules traditionally relies on nucleophilic activation, often requiring strong bases or metal catalysts. These conditions, however, restrict applications involving biomolecules such as peptides and proteins due to functional group incompatibility.

[Estimation of Soil Organic Carbon Content in Gannan Grassland Based on SSA Optimized CatBoost].

Estimating the content of soil organic carbon （SOC） in Gannan Tibetan Autonomous Prefecture, studying its spatial distribution characteristics, and clarifying the main influencing factors of SOC are of great significance for improving grassland quality, optimizing management, regulating climate, and maintaining ecosystem functions. Taking the grassland in Gannan Tibetan Autonomous Prefecture of Gansu Province as the research object, multi-feature factor data were constructed by integrating data such as soil properties, meteorological factors, elevation, and vegetation index, and 24 significant feature factors were screened out using Pearson correlation analysis. Then, the normalized contribution degree was obtained according to the SHAP value.

Magnetic Field Induced Quantum Metric Dipole in Dirac Semimetal Cd_{3}As_{2}.

The quantum geometry, comprising Berry curvature and quantum metric, plays a fundamental role in governing electron transport phenomena in solids. Recent studies show that the quantum metric dipole drives scattering-free nonlinear Hall effect in topological antiferromagnets, prompting the questions of whether this effect can occur in nonmagnetic systems and be externally tuned by a magnetic field. Our work addresses these frontiers by demonstrating that the quantum metric dipole is actively tuned by an external magnetic field to generate a time-reversal-odd nonlinear Hall response in a nonmagnetic topological Dirac semimetal Cd_{3}As_{2}.

Shared Decision-Making in Medications for Elderly Patients with Multi-Morbidities: A Phenomenological Study.

Objective: To explore the willingness, needs, and factors influencing participation in medication decision-making among elderly patients with multi-morbidities, caregivers, and healthcare professionals.

Methods: A phenomenological research method was used to conduct semi-structured interviews with elderly patients with multi-morbidities, caregivers, and healthcare professionals. The purposive sampling method was used to select geriatric patients with multi-morbidities, their caregivers, and healthcare workers from March to July 2024 in the Geriatrics, Cardiology, Endocrinology, Respiratory, and Nephrology Departments of a tertiary hospital in Shanxi Province as the study subjects.

Peptide-Carbazolyl Cyanobenzene Conjugates: Enabling Biomolecule Functionalization via Photoredox and Energy Transfer Catalysis.

Since their discovery in 2012, carbazolyl (iso)phthalonitrile (Cz(I)PN) derivatives have found significant applications as photocatalysts (PCs) in organic chemistry. Herein, we introduce two efficient methods for incorporating carbazolyl cyanobenzenes into various peptide sequences. The first method involves a photomediated decarboxylative functionalization of the C-terminus of peptides, leading to the formation of various carbazolyl benzonitrile (CzBN) derivatives.

Multiple Antennal Sensory Membrane Neuron Protein Genes Mediate Rice Plant Host Location in the White-Backed Planthopper.

While the sensory neuron membrane protein (SNMP) family has been linked to sex pheromone detection, roles in other olfactory-associated and nonolfactory functions have not been as well-defined. In this study, four SNMP genes were identified for the white-backed planthopper (; WBPH), a major pest of rice plants. Tissue-specific transcriptomic data indicated that all four are not only expressed in the antennae to varying levels but also observed in several non-olfactory tissues.

Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes.

Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients have experienced high levels of oxidative stress, which can lead to inflammation or damage. Withaferin A is a natural product with multiple pharmacological activities, including anti-tumor and anti-inflammatory effects.

Simultaneous high molecular weight PAHs degradation and chromate and arsenite detoxification by Altererythrobacter sp. H2.

The cooccurrence of high molecular weight PAHs and heavy metals Cr and As is frequently observed in soil and water and challenges public health and environmental management. Yet the limited microbial resources were reported to simultaneously detoxify PAHs, Cr(VI) and As(III), which restricts the bioremediation of co-contaminated soil by PAHs, Cr and As. Here, we isolated Altererythrobacter sp.

[Effects of nicotine exposure on endogenous metabolites in mouse brain based on metabolomics and mass spectrometry imaging].

Nicotine, the principal alkaloid in tobacco, exhibits significant central nervous system activity and induces a wide array of physiological effects. In addition to its well-documented role in tobacco dependence, previous studies have suggested that nicotine also has diverse pharmacological properties. These include alleviating symptoms associated with Parkinson's disease, potentially reducing the risk of Alzheimer's disease, mitigating oxidative stress, as well as anti-inflammatory and anxiolytic effects.

Combination of ultrasound and supercritical carbon dioxide extraction for trigonelline production from Quisqualis indica.

Trigonelline is a natural alkaloid with important nutrient benefits. A hybrid technique adopting ultrasound-assisted supercritical CO extraction (UASCE) was exploited for extraction of trigonelline from Quisqualis indica. Response surface methodology was used to optimize operational parameters of the UASCE process, which indicated that the highest trigonelline yield (TY), 4.

Functional exploration of the Sex combs reduced gene in Gryllus bimaculatus.

The Hox gene Sex combs reduced (Scr) is recognized as a key factor in the development of the head and thorax in insects. However, its function in the growth, development and morphogenesis of Gryllus bimaculatus remains poorly understood. This study aimed to explore the function of the Scr gene in G.

Giant Third-Order Nonlinearity Induced by the Quantum Metric Quadrupole in Few-Layer WTe_{2}.

The quantum geometric properties of topological materials underpin many exotic physical phenomena and applications. Quantum nonlinearity has emerged as a powerful probe for revealing these properties. The Berry curvature dipole in nonmagnetic materials and the quantum metric dipole in antiferromagnets have been explored by studying the second-order nonlinear Hall effect.

Balancing the solar irradiance needs: optimising growth in sphagnum palustre through tailored UV-B effects.

Background: The carbon sequestration potential and water retention capacity of peatlands are closely linked to the growth dynamics of Sphagnum mosses. However, few studies have focused on the response of Sphagnum moss growth dynamics to UV-B radiation, and existing research has emphasized species differences. In this study, Sphagnum palustre L.

Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice.

Immune cells and interleukins play a crucial role in female-specific pain signaling. Interleukin 16 (IL-16) is a cytokine primarily associated with CD4 T cell function. While previous studies have demonstrated the important role of spinal CD4 T cells in neuropathic pain, the specific contribution of IL-16 to neuropathic pain remains unclear.

Efferocytosis: Unveiling its potential in autoimmune disease and treatment strategies.

Efferocytosis is a crucial process whereby phagocytes engulf and eliminate apoptotic cells (ACs). This intricate process can be categorized into four steps: (1) ACs release "find me" signals to attract phagocytes, (2) phagocytosis is directed by "eat me" signals emitted by ACs, (3) phagocytes engulf and internalize ACs, and (4) degradation of ACs occurs. Maintaining immune homeostasis heavily relies on the efficient clearance of ACs, which eliminates self-antigens and facilitates the generation of anti-inflammatory and immunosuppressive signals that maintain immune tolerance.

[Effect and mechanism of free total rhubarb anthraquinones on pyroptosis of J774A.1 macrophages].

In this study, J774A.1 macrophages stimulated by lipopolysaccharide(LPS) and adenosine triphosphate(ATP) were used to establish an in vitro model of pyroptosis, and the intervention mechanism of free total rhubarb anthraquinones(FTRAs) on pyroptosis was investigated. J774A.

Hypervalent Iodine Amino Acid Building Blocks for Bioorthogonal Peptide Macrocyclization.

Ethynylbenziodoxol(on)es (EB(X)xs) reagents have emerged as useful reagents for peptide/protein modification due to their versatile reactivity and high selectivity. Herein, we report the successful introduction of ethynylbenziodoxoles (EBxs) on different amino acid building blocks (Lys/Orn/Dap), and show their compatibility with both solid phase peptide synthesis (SPPS) and solution phase peptide synthesis (SPS). The selective incorporation of the EBx core into peptide sequences enable efficient macrocyclizations under mild conditions for the synthesis of topologically unique cyclic and bicyclic peptides.

New method for calculating the windward area of irregular fragments.

Average windward area is an important index for calculating the trajectory, velocity attenuation and terminal effect of explosive fragments. In order to solve the problems that existing theoretical method cannot calculate windward area of irregular fragment and experiment method is not convenient for automatic calculation and has low accuracy, a Monte Carlo subdivision projection simulation algorithm is proposed. The average windward area of arbitrary shaped fragments can be obtained with coordinate translation, random rotation, plane projection, convex-hull triangulation, concave boundary searching and sorting with maximum edge length constraint, subdivision area calculation, and averaging by thousands of cycles.

Quality Evaluation of Shexiang Tongxin Dropping Pill Based on HPLC Fingerprints Combined with HPLC-Q-TOF-MS/MS Method.

Shexiang Tongxin Dropping Pill (STP) is a composite formula of traditional Chinese medicine that is widely used for the treatment of cardiovascular diseases. It consists of seven medicinal extracts thereof or materials, including Bufonis venenum, synthetic Moschus, Panax ginseng, Bovis calculus artifactus, Bear bile powder, Salvia miltiorrhiza Bge and synthetic borneol. However, it is considerably difficult to evaluate the quality of STP due to its complex chemical compositions.

[Liver targeting of compound liposomes mediated by glycyrrhetinic acid derivative receptor and its effect on hepatic stellate cells].

The 3-succinate-30-stearyl glycyrrhetinic acid(18-GA-Suc) was inserted into glycyrrhetinic acid(GA)-tanshinone Ⅱ_A(TSN)-salvianolic acid B(Sal B) liposome(GTS-lip) to prepare liver targeting compound liposome(Suc-GTS-lip) mediated by GA receptors. Next, pharmacokinetics and tissue distribution of Suc-GTS-lip and GTS-lip were compared by UPLC, and in vivo imaging tracking of Suc-GTS-lip was conducted. The authors investigated the effect of Suc-GTS-lip on the proliferation inhibition of hepatic stellate cells(HSC) and explored their molecular mechanism of improving liver fibrosis.

Type II Abernethy malformation with cystic fibrosis in a 12-year-old girl: A case report.

Background: Abernethy malformation, also known as congenital extrahepatic portosystemic shunt, is an uncommon malformation resulting from aberrant development of the portal venous system. Cystic fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the gene. It mainly affects the exocrine glands of the respiratory, digestive and reproductive systems.

Synthesis of Fluorescent Cyclic Peptides via Gold(I)-Catalyzed Macrocyclization.

Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are of high importance for medicinal chemistry. Herein, we report the first gold(I)-catalyzed macrocyclization of peptide-EBXs (ethynylbenziodoxolones) via C-Trp C-H activation. This reaction was carried out in the presence of protecting group free peptide sequences and is enabled by a simple commercial gold catalyst (AuCl·MeS).

Gate-Tunable Berry Curvature Dipole Polarizability in Dirac Semimetal Cd_{3}As_{2}.

We reveal the gate-tunable Berry curvature dipole polarizability in Dirac semimetal Cd_{3}As_{2} nanoplates through measurements of the third-order nonlinear Hall effect. Under an applied electric field, the Berry curvature exhibits an asymmetric distribution, forming a field-induced Berry curvature dipole, resulting in a measurable third-order Hall voltage with a cubic relationship to the longitudinal electric field. Notably, the magnitude and polarity of this third-order nonlinear Hall effect can be effectively modulated by gate voltages.

Eosinophilic granulomatosis with polyangiitis, asthma as the first symptom, and subsequent Loeffler endocarditis: A case report.

Background: Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a rare form of anti-neutrophil cytoplasmic antibody-associated vasculitis characterized by asthma, vasculitis, and eosinophilia.

Case Summary: We report an atypical case of EGPA in a 20-year-old female patient. Unlike previously reported cases of EGPA, this patient's initial symptom was asthma associated with a respiratory infection.