Role of Immunity and Inflammation in Sarcopenic Obesity.

The global aging population brings about various age-related clinical concerns, including sarcopenic obesity (SO), which poses a significant health risk for older individuals. SO is characterized by the coexistence of two phenotypes, namely, sarcopenia and obesity, and its pathogenesis is multifaceted. Current research indicates that both reduced muscle mass and excessive fat accumulation are associated with chronic low-grade inflammatory conditions.

High-intensity interval training alleviates exhaustive exercise-induced HSP70-assisted selective autophagy in skeletal muscle.

This study was designed to probe the effect of chaperone-assisted selective autophagy (CASA) on the maintenance of proteostasis during exhaustive exercise and uncover the alteration of CASA in muscle fibers with pre-high-intensity interval training (HIIT) intervention-induced muscle adaptation in response to exhaustive exercise. Rats were randomly divided into a control group; an exhaustive exercise group; and an HIIT + exhaustive exercise group. Results show myofibril damage and BiP levels were increased after exhaustive exercise, and the levels of the HSP70, BAG3, ubiquitin, autophagy-related proteins, and their interactions were increased.