Fat-cartilage axis: the regulation of IL-6/Osteopontin signaling in osteoarthritis of mice.

The infrapatellar fat pad (IPFP) acts as a bioactive reservoir, secreting proinflammatory cytokines that orchestrate both local and systemic inflammatory cascades. Despite its emerging role in knee osteoarthritis (OA) pathophysiology, the molecular and cellular mechanisms driving IPFP-mediated disease progression remain a critical gap in mechanistic understanding. 12-week-old male C57BL/6 mice underwent either destabilization of the medial meniscus (DMM) surgery or Sham surgery.

[Spatial Differentiation Characteristics and Influencing Factors of Surface Soil Cd in Karst Plateau Area of Guiyang City].

In order to explore the spatial differentiation characteristics and variation law of soil Cd content in a high geological background area, 14 421 topsoil samples were collected from topsoil in the karst area of Guiyang City. Global Moran's index, cold hot spot analysis, semi-variance function, and Kriging interpolation were used to reveal the spatial structure and distribution law of soil Cd content. The influence of environmental factors on soil Cd content and its main controlling factors were analyzed through analysis of variance and geographic detector.

A global transcriptional activator involved in the iron homeostasis in cyanobacteria.

Cyanobacteria use a series of adaptation strategies and a complicated regulatory network to maintain intracellular iron (Fe) homeostasis. Here, a global activator named IutR has been identified through three-dimensional chromosome organization and transcriptome analysis in a model cyanobacterium sp. PCC 6803.

Effect of acupuncture at neck-Jiaji (EX-B 2) and on the cognitive function in the patients with subjective cognitive decline.

Objectives: To observe the effects on cognitive function, sleep quality and hemodynamics in the patients with subjective cognitive decline (SCD) after treated with acupuncture at neck-Jiaji (EX-B 2) and on the base of healthy lifestyle education and meta-memory training.

Methods: Sixty SCD patients were randomly divided into an observation group (30 cases, 1 case dropped out) and a control group (30 cases, 3 cases dropped out). In the control group, the healthy lifestyle education and meta-memory training was performed, twice daily, 15 min each time; the 5-day intervention was delivered a week, lasting consecutively 4 weeks.

[Hydrochemical Characteristics and Control Factors of Groundwater in Shunping County, Hebei Province].

In order to study the chemical characteristics and ion source of groundwater and further serve the scientific development and management of water resources in Shunping County. A total of 33 groups of karst water and 12 groups of pore water samples were collected systematically in Shunping County, and the hydrochemical types, composition characteristics, and main controlling factors of various types of groundwater were analyzed by using Gibbs diagram, ion ratio relation, and multivariate statistical analysis methods, and the contribution rates of various sources to groundwater solutes were evaluated. The results showed that the pore water and karst water in the study area were weakly alkaline, with TDS ranging from 245.

[Spatial Distribution Characteristics and Source Analysis of Heavy Metals in Soil of a Lead Plant in Sanmenxia].

At present, a large-scale relocation of industrial enterprises is taking place in major cities in China, and a large number of contaminated relocation sites are being generated, among which the heavy metal pollution is particularly serious. In order to analyze the pollution status, spatial distribution, and sources of heavy metals in the soil of a lead factory in Sanmenxia, the spatial variation and distribution characteristics of heavy metals in the soil were analyzed using geostatistics, and the main sources of heavy metals in the soil were analyzed using a PMF model. The results showed that the average values of As, Cd, Cu, Pb, Hg, and Ni in the soil far exceeded the background values of the soil environment in Henan province; the contents of As, Cd, Pb, and Hg exceeded the screening values of soil pollution risk; and the contents of As, Pb, and Hg exceeded the control values of soil pollution risk.

[Spatial Variation and Influencing Factors of Soil pH in Anshun City].

Exploring the spatial distribution characteristics and variation law of soil pH and analyzing the impact of environmental factors on the spatial differentiation of soil pH are of great significance to the accurate management of soil pH and the sustainable utilization of soil resources in the complex mountainous environment of Anshun City. Based on 22 851 field sampling points, using the methods of global Moran's index, cold and hot spot analysis, semi-variance function, and Kriging interpolation, the spatial structure characteristics and distribution law of soil pH in Anshun City were revealed from different angles, and the influence of environmental factors on its spatial differentiation was analyzed with the help of geographic detectors. The results showed that:① the variation range of topsoil pH value in Anshun City was 3.

Enhanced Radical Generation in an Ultraviolet/Chlorine System through the Addition of TiO.

Ultraviolet (UV)/chlorine draws increasing attention for the abatement of recalcitrant organic pollutants. Herein, it was found that TiO would significantly promote the degradation of dimethyl phthalate (DMP) in the UV/chlorine system (from 19 to 84%). Hydroxyl radicals (HO) and chlorine radicals (Cl) were the dominant reactive species for DMP degradation in the UV/chlorine/TiO system.

Deep learning for automatically predicting early haematoma expansion in Chinese patients.

Background And Purpose: Early haematoma expansion is determinative in predicting outcome of intracerebral haemorrhage (ICH) patients. The aims of this study are to develop a novel prediction model for haematoma expansion by applying deep learning model and validate its prediction accuracy.

Methods: Data of this study were obtained from a prospectively enrolled cohort of patients with primary supratentorial ICH from our centre.

Knockdown of FOXM1 attenuates inflammatory response in human osteoarthritis chondrocytes.

Osteoarthritis (OA) is the most common inflammatory joint disease that is mainly characterized by articular cartilage destruction. Forkhead box M1 (FOXM1) is a transcription factor that acts as a critical mediator of inflammatory response. However, the role of FOXM1 in OA has not been investigated.

[Fate and Toxicity of UV Filters in Marine Environments].

UV filters have been widely used in sunscreen products, and they have partially ended up in the marine environment via human recreational activities and sewage treatment plant drainage, becoming one of the emerging marine pollutants. As UV filters have many characteristics, such as extensive use, continuous emissions, and stability, their potential risks to the environment and ecology have become a hot topic in the field of environmental research all over the world. This study analyzed the environmental behavior of UV filters in the ocean, such as migration, transformation, and volatilization.

[Effect of occlusal reconstruction on cerebral blood flow and cerebral oxygen saturation in patients with malocclusion].

Objective: To investigate the effect of occlusal reconstruction on blood flow velocity and cerebral oxygen saturation in patients with malocclusion.

Methods: Thirty-three patients with malocclusion treated with occlusal reconstruction in Department of Stomatology, Medical School of Huzhou Normal College from Feb 2011 to Oct 2013 were enrolled in the study. The systolic peak flow velocity (vs), end-diastolic peak flow (vd) , mean peak flow velocity (vm) of middle cerebral artery and the oxygen saturation (rScO2) in the brain were detected at rest or chewing status by using transcranial Doppler color ultrasonography and near-infrared spectroscopy, respectively.

[Construction and identification of anti-HER2 phage display single chain fragment of variable region library in human breast cancer].

Objective: To construct human phage single-chain antibody (scFv) library against breast cancer, and to identify anti-HER2 specific antibodies from the human phage display scFv library to offer a stronger affinity sequence targeting HER2 for fusion protein targeting HER2 and CXCR4.

Methods: Total RNA was extracted from the adjacent lymphatic tissue harvested from breast cancer patients. The variable regions of the whole antibody were amplified by using RT-PCR and were cloned into the vector pCANTAB-5E through a linker.

Two structurally analogous ruthenium complexes as naked-eye and reversible molecular "light switch" for G-quadruplex DNA.

A pair of symmetrical furyl based ruthenium(II) complexes ([Ru(phen)2dpq-df](2+) (1) and [Ru(bpy)2dpq-df](2+) (2) (phen=1,10-phenanthroline, bpy=2,2'-bipyridine, dpq-df=dipyrido (3,2-a:2',3'-c) quinoxaline-difuran) have been prepared and characterized. The binding properties of both complexes toward G-quadruplex DNA have been investigated by fluorescence spectroscopy, UV-Vis spectroscopy, circular dichroism (CD), fluorescence resonance energy transfer (FRET) melting assays and molecular docking studies. The experimental results indicated that both Ru-complexes exhibited a remarkable "light switch" effect in the presence of hybrid G-quadruplex DNA.

Effects of land use and parent materials on trace elements accumulation in topsoil.

To determine the effects of parent material and land use on the concentration of trace elements in the agricultural topsoil of Guizhou Province, China, a total of 584 agricultural topsoil samples were collected in a typical region. The results indicate that the contents of trace elements (As, Cd, Cr, Hg, and Pb) in agricultural soils were greater than in the uncultivated soils, and the paddy fields exhibited higher contents of trace elements than dry lands. The enrichments of most trace elements in agricultural topsoil derived from carbonate rock were more serious.

Bullet migration from the knee to the heart after a gunshot injury: a case report.

Migration of a bullet to a distant part of the body after a gunshot is rarely observed in the clinical setting, and migration to the heart is even rarer. There are usually no clear symptoms or signs from migration of a bullet. The bullet can be easily missed and sometimes identified in a review examination.

Postinduction requirement of NMDA receptor activation for late-phase long-term potentiation of developing retinotectal synapses in vivo.

Spaced patterns of repetitive synaptic activation often result in a long-lasting, protein synthesis-dependent potentiation of synaptic transmission, known as late-phase long-term potentiation (L-LTP) that may serve as a substrate for long-term memory. Behavioral studies showed that posttraining blockade of NMDA subtype of the glutamate receptor (NMDAR) impaired long-term memory, although NMDAR activation is generally known to be required during LTP induction. In this study, we found that the establishment of L-LTP in vivo requires NMDAR activation within a critical time window after LTP induction.