Molecular-level insights into directional condensation mechanism of phenolic acids during humic substance formation.

The regulation of humic substance formation during aerobic fermentation of organic solid waste has gradually become a research hotspot in related fields. The metabolic byproducts of lignocellulose have the potential to act as precursors for the synthesis of humic substances. This study, grounded in a robust framework of metabolic intermediate indicators, selected representative pure phenolic acid intermediates to conduct condensation experiments.

Elucidating the clay-mediated fixation mechanism of humic acids in composting systems using LC-MS and spectroscopic techniques.

Humic acid (HA) plays a vital role in improving soil fertility and resource utilization. However, traditional composting faces challenges such as low HA synthesis efficiency and significant mineralization losses. This study investigates the molecular-level mechanisms by which clay mineral addition enhances HA fixation during composting.

Characterization of manganese(II)-coupled functional microorganisms in driving lignin degradation during straw composting.

The intricate structure of lignin in straw makes it challenging to hydrolyze, making it a key focus of current research. However, there has been limited study on the effect of enzyme inducer (MnSO) combined with functional microorganisms on lignin degradation during straw composting. Based on this, four composting treatment groups were set up in this study.

Potent protein tyrosine phosphatase 1B (PTP1B) inhibiting constituents from Anoectochilus chapaensis and molecular docking studies.

Context: Anoectochilus chapaensis Gagnep. (Orchidaceae), an indigenous and valuable Chinese folk medicine, has been used as an antidiabetic remedy. However, the bioactive constituents have not been reported.

Potential synergistic effects of Chinese herbal prescription FTZ components detected in blood towards hepatic lipid-modulating targets.

Objective: Our goal in this study aims to explain the polypharmacological mechanism at the molecular level responsible for the effectiveness of a traditional Chinese medicine (TCM) prescription FTZ to treat hyperlipidemia and related disease.

Design: By MDL(®) ISIS_Base 2.5, we constructed a compound database based on the FTZ constituents, which were detected in the rat serum after oral administration of the TCM through ultra-performance liquid chromatography/quadruple-time-of-flight mass-spectrometry (UPLC/Q-TOF-MS/MS) method.