Publications by authors named "Wei-Ping Zhang"
Introduction: The aim of this study is to explore the relationship between school bullying, depression, academic anxiety, and home-school cooperation among Chinese primary and secondary school students, with a focus on promoting students' mental wellbeing in the post-COVID-19 era.
Methods: A survey was conducted among 3,600 Chinese primary and secondary school students using the Depression Scale, School Bullying Scale, Academic Anxiety Scale, and Home-School Cooperation Scale. A total of 3,341 students were selected as research subjects to examine the mediating and moderating mechanisms of academic anxiety and home-school cooperation in the relationship between school bullying and depression.
Autologous hematopoietic stem cell transplantation (ASCT) in multiple myeloma (MM) can cause engraftment syndrome (ES), a clinical diagnosis without specific laboratory biomarkers. Herein, six cytokines commonly elevated during transplantation were chronologically detected during ASCT in 96 patients with newly diagnosed MM, 24.0 % of whom experienced ES.
View Article and Find Full Text PDFUbiquitin (Ub), a central regulator of protein turnover, can be phosphorylated by PINK1 (PTEN-induced putative kinase 1) to generate S65-phosphorylated ubiquitin (pUb). Elevated pUb levels have been observed in aged human brains and in Parkinson's disease, but the mechanistic link between pUb elevation and neurodegeneration remains unclear. Here, we demonstrate that pUb elevation is a common feature under neurodegenerative conditions, including Alzheimer's disease, aging, and ischemic injury.
View Article and Find Full Text PDFPINK1 deficiency alleviates bleomycin-induced pulmonary fibrosis in mice.
Cell Signal
September 2025
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive lung disorder marked by deteriorating dyspnea and declining pulmonary function. Despite its rising prevalence and incidence, therapeutic options remain limited. PTEN-induced kinase 1 (PINK1), known for its role in PINK1/Parkin-dependent mitophagy, contributes to the pathogenesis of various lung diseases.
View Article and Find Full Text PDFPurpose: This multicenter study aimed to identify risk factors for postoperative complications following tubularized incised plate urethroplasty (TIP) in hypospadias patients and develop a clinical prediction model.
Methods: Retrospective data from 17 tertiary centers (2018-2021) were analyzed.
Inclusion Criteria: primary TIP surgery with complete anatomical and follow-up data.
Interactive and joint effects of toxic metals and oxidative balance score on the risk of mortality in adults with NAFLD.
Ecotoxicol Environ Saf
March 2025
Background: High oxidative balance score (OBS) may mitigate inflammation levels and thereby alleviate the adverse health effects induced by toxic metals. We assessed the independent, joint effects as well as their interactions of toxic metals and OBS on mortality among individuals with non-alcoholic fatty liver diseases (NAFLD).
Methods: Participants with NAFLD from the National Health and Nutrition Examination Survey (NHANES) 1999-2018 were included.
Isolated male epispadias typically presents with preputial defects and dorsal urethral dehiscence. A less common subtype, known as concealed epispadias, is distinguished by an intact prepuce. Despite its clinical relevance, there is limited literature on this variant.
View Article and Find Full Text PDFOral-drug based regimens are useful in certain circumstances for transplant-ineligible newly diagnosed multiple myeloma (TI-NDMM), but few studies have compared Ixazomib based regimen with lenalidomide based regimen head-to-head. We carried out a prospective randomized, open, parallel group trial in patients with TI-NDMM in 3 China centers from March 2020 to December 2022. Sixty-three patients were available for final analysis, ICd (Ixazomib/cyclophosphamide/dexamethasone, n = 31) and RCd (lenalidomide/cyclophosphamide/dexamethasone, n = 32).
View Article and Find Full Text PDFDivergent responses of an armored and an unarmored dinoflagellate to ocean acidification.
Harmful Algae
January 2025
Dinoflagellates, both armored and unarmored, with distinct cell wall difference, are being affected by elevated CO-induced ocean acidification (OA). However, their specific responses to OA are not well understood. In this study, we investigated the physiological and molecular response of the armored species Prorocentrum obtusidens and the unarmored species Karenia mikimotoi to OA over a 28-day period.
View Article and Find Full Text PDFThe alteration of interspecific interaction responded to various relative sowing time in wheat/maize intercropping.
Front Plant Sci
November 2024
Article Synopsis
- The study investigates how the timing of sowing different crops (wheat and maize) affects their competitiveness and yield when intercropped compared to being grown separately.
- Field experiments were conducted over two years with various sowing times and planting methods, revealing that delaying wheat sowing reduced its yield while increasing maize's, yet wheat maintained a competitive edge during growth.
- Ultimately, aligning the sowing times of wheat and maize shifted their interaction from unbalanced to more mutually beneficial, but wheat still retained some competitive advantages despite these changes.
Ablation of NAMPT in dopaminergic neurons leads to neurodegeneration and induces Parkinson's disease in mouse.
Brain Res Bull
November 2024
Article Synopsis
- - Nicotinamide phosphoribosyltransferase (NAMPT) is vital for producing nicotinamide adenine dinucleotide (NAD) and has been studied for its protective effects in neurodegeneration, particularly in Alzheimer's Disease, but its role in Parkinson's Disease (PD) is less understood.
- - Research indicates that dopaminergic neurons in the substantia nigra have higher NAMPT levels, and removing NAMPT leads to the loss of these neurons, dopamine pathway impairment, and symptoms similar to PD in mice.
- - The study suggests that NAD precursor nicotinamide ribose (NR) can counteract neurodegeneration in PD by repairing dopamine pathways and highlights the potential for using NAD precursors in
Qualitative and quantitative analysis of solid renal tumors by high-frame-rate contrast-enhanced ultrasound.
Cancer Imaging
October 2024
Article Synopsis
- - The study aimed to explore the features of high-frame-rate contrast-enhanced ultrasound (H-CEUS) in solid renal tumors by analyzing 89 renal masses from 75 patients through both qualitative and quantitative assessments.
- - Researchers observed significant differences in various characteristics (like gender, surgical approach, and echogenicity) between benign and malignant tumors, as well as differences in wash-out patterns and enhancement uniformity between conventional contrast-enhanced ultrasound (C-CEUS) and H-CEUS.
- - Quantitative findings showed that several time-intensity curve (TIC) parameters were notably lower in H-CEUS compared to C-CEUS for both benign and malignant tumors, indicating potential differences in tumor assessment between the
Article Synopsis
- * A study revealed that rising temperatures (from 22°C to 26°C) significantly influenced the dinoflagellates, enhancing growth and photosynthetic efficiency but decreasing overall nutrient content.
- * The research highlighted that elevated temperatures interact with other stressors, leading to heightened energy production and material synthesis, showcasing the complex effects of combined environmental changes on these organisms.
Article Synopsis
- Central precocious puberty due to Leydig cell tumors is rare but was observed in a retrospective study of 12 children treated at Beijing Children's Hospital from 2016 to 2023.
- The analysis included various clinical evaluations, and all patients showed abnormal hormone levels, with ten experiencing peripheral precocious puberty at admission.
- The study found a high occurrence of central precocious puberty post-surgery, with effective treatment using gonadotropin-releasing hormone analogs, though more extensive research is recommended for future insights.
[Analysis of risk factors for postoperative delirium in elderly patients undergoing spinal surgery].
Zhongguo Gu Shang
July 2024
Article Synopsis
- - The study aimed to identify risk factors for postoperative delirium in elderly patients (average age ~71.58 years) undergoing spine surgery, analyzing data from 566 patients over two years.
- - Univariate analysis linked several factors—such as age, duration of surgery, preoperative anxiety, blood loss, and history of opioid use—to higher incidences of delirium post-surgery, with 41 patients affected.
- - Binary Logistic regression confirmed that age, opioid use, blood loss, preoperative anxiety, and elevated C-reactive protein levels were independent risk factors for developing delirium in this population.
Article Synopsis
- The research focuses on integrating carbon neutrality goals into territorial planning for Gansu Province to enhance sustainable development and reduce carbon emissions.
- An analysis of land use carbon budgets from 87 counties over different years highlighted rising carbon emissions, with construction land being a primary source and woodlands serving as essential carbon sinks.
- The study identified a "core-edge" model in carbon emission networks, indicating key areas in Gansu that play crucial roles in overall carbon dynamics and proposing differentiated low-carbon development strategies for effective regional management.
Article Synopsis
- * A total of 70 patients were analyzed, divided into three groups based on how the tumors interacted with the collecting system, with varying rates of surgery success and tumor recurrence.
- * Overall, the results showed similar survival rates but highlighted the challenges of preserving kidney tissue while managing tumor growth and preventing long-term renal issues.
Article Synopsis
- Non-clear cell renal cell carcinoma (nccRCC) is a rare form of kidney cancer that can be misdiagnosed, making it crucial to identify its unique characteristics through contrast-enhanced ultrasound (CEUS).
- This study analyzed imaging features from 21 patients with confirmed nccRCC to evaluate the effectiveness of both qualitative and quantitative CEUS in diagnosis.
- The results revealed that nccRCC commonly shows specific traits in ultrasound imaging, like hypoechoic appearance and clear boundaries, and CEUS analysis indicated significant differences in blood flow parameters between nccRCC lesions and normal renal tissue.
Article Synopsis
- The study aimed to create a deep learning radiomics network (DLRN) that combines ultrasound images, radiomics, and clinical features to differentiate between parotid pleomorphic adenoma (PA) and adenolymphoma (AL).
- A total of 287 patients were used in various cohorts for training and validating machine learning classifiers that generated different models, including logistic regression and deep learning radiomics models.
- The DLRN model outperformed other models in distinguishing between PA and AL, demonstrating a significant enhancement in diagnostic accuracy and providing an important non-invasive solution for clinicians.
Article Synopsis
- Ghost introgression involves the transfer of genetic material from extinct lineages into currently existing species, with limited evidence found in plants, particularly for Carya sinensis and Carya cathayensis.
- Researchers assembled chromosome-level genomes for these species and re-sequenced 43 C. sinensis individuals and 11 diploid hickory species to explore genetic patterns and confirm ghost introgression.
- Their analysis, employing methods like D-statistic and BPP alongside phylogenetic network analysis, provided strong evidence of ghost introgression in C. sinensis from an extinct lineage, enhancing the understanding of Carya's evolutionary history and biogeography.
Article Synopsis
- - The study aimed to assess how effective high-frame-rate contrast-enhanced ultrasound (H-CEUS) is in distinguishing between two types of kidney tumors: clear cell renal cell carcinoma (CCRCC) and angiomyolipoma (AML).
- - Researchers analyzed data from 110 patients (79 with CCRCC and 31 with AML) who underwent ultrasound and H-CEUS exams before surgery, utilizing various statistical methods to identify differences in tumor characteristics and risk factors.
- - Results showed significant differences in clinical features and ultrasound characteristics between the two groups, particularly in aspects like blood flow and enhancement patterns, indicating H-CEUS could be a promising diagnostic tool for differentiating these tumors.
Characteristics of high frame frequency contrast-enhanced ultrasound in renal tumors.
BMC Med Imaging
March 2024
Article Synopsis
- This study focuses on assessing high frame rate contrast-enhanced ultrasound (H-CEUS) to differentiate between benign and malignant renal tumors in patients.
- A total of 140 patients underwent various ultrasound examinations, and their results were compared using statistical methods to analyze differences in various characteristics of the tumors.
- Key findings indicated significant differences in factors like gender, nodule composition, echo patterns, and blood flow between benign and malignant lesions, highlighting H-CEUS’s potential for improving diagnostic accuracy.
Article Synopsis
- PARP-1 activity increases significantly during cerebral ischemia/reperfusion, leading to NAD deficiency and contributing to neuronal death.
- Activation of PARP-1 results in PARylation of key metabolic enzymes, hexokinase-1 and lactate dehydrogenase-B, disrupting energy metabolism in neurons.
- Inhibiting PARP-1 improves enzyme activity, reduces brain injury, and, when combined with pyruvate, shows promise as a therapeutic strategy for ischemic brain injury in mice.