Prevalence of Physical Activity Maintenance Across a 12-Month Study: Comparison of Accelerometer Indicators.

Background: Maintaining physical activity (PA) is critical for reducing disease risk. Yet, lack of consensus on how to define and operationalize PA maintenance has hindered surveillance efforts. We used longitudinal accelerometer data to compare how different ways of operationalizing PA maintenance impact PA maintenance prevalence estimates.

[Analysis of Carbon Emission Characteristics and Influencing Factors of Different Land Use Types in Hunan Province].

It is important to explore the development path of urban low-carbon economies and formulate climate control policies to analyze the spatial and temporal evolution characteristics of land use carbon emissions and their influencing factors by accounting for carbon emissions from different land use types. Our study measured the carbon emissions of different land-use types in Hunan Province in 2010 and 2019. We used the OLS model to determine the influencing factors of land use carbon emissions based on the framework for land use carbon emissions using land use and cover and statistical data.

Screen time and allostatic load among youth: findings from the National Health and Nutrition Examination Survey, 2015-2018.

Background: More screen time (ST) is associated with dysregulation of the individual biological systems (cardiovascular, immune, metabolic, and neuroendocrine) involved in the stress response in youth. However, its relationship with allostatic load (AL), a measure of the cumulative physiological stress response, is unclear in youth.

Purpose: To investigate the associations between ST types and AL outcomes in youth and to explore sociodemographic and behavioral moderators of these relationships.

Randomized trial of a digital therapeutics intervention to enhance affective response during physical activity: Protocol for the eMOTION study.

Physical activity interventions often fail to address features of physical activity that may lead to maintaining behavior, such as emotional experiences during behavior. Although some people experience pleasure during physical activity, it can be extremely unpleasant for others. Affective mechanisms (e.

Redox-driven hybrid nanoenzyme dynamically activating ferroptosis and disulfidptosis for hepatocellular carcinoma theranostics.

Hepatocellular carcinoma (HCC) presents formidable therapeutic challenges due to its pronounced metabolic heterogeneity, particularly arising from spatially uneven glucose availability within the tumor microenvironment (TME). To address this, we developed a glutathione (GSH)-responsive, biomimetic hybrid nanoenzyme system (M@GOx/Fe-HMON) composed of hollow mesoporous organosilica nanoparticles co-loaded with glucose oxidase (GOx) and Fe/Fe redox pairs, and cloaked in homologous tumor cell membranes for enhanced targeting. In glucose-rich regions, the nanoenzyme orchestrates a GOx-peroxidase (POD) cascade that produces reactive oxygen species (ROS) via the Fenton reaction, leading to ferroptosis through intensified oxidative stress and GSH depletion.

Positive Pyramidal Sign as an Unexpected Presentation in Antipsychotic-Induced Acute Dystonia: Case Reports and Literature Review.

Background: Acute drug-induced dystonia (DID) is an extrapyramidal side effect triggered by certain medications, primarily antipsychotics. It presents as acute involuntary muscle contractions, causing twisting, repetitive movements, or abnormal postures. Pyramidal signs, typically from upper motor neuron damage, are characterized by positive pathological reflexes, increased muscle tone, and hyperactive tendon reflexes.

Exploring person-centred sleep and rest-activity cycle dynamics over 6 months.

Sleep and circadian characteristics are associated with health outcomes, but are often examined cross-sectionally or using variable-centred analyses. Person-centred longitudinal research is needed to identify combined effects of sleep and circadian characteristics while allowing for change over time. We aimed to classify individuals into sleep-circadian statuses (aim 1), determine whether they transitioned between statuses over time (aim 2), and explore associated covariates and health outcomes (aim 3).

Particular Chinese contributions to extracorporeal liver surgery.

Extracorporeal liver surgery (ELS), also known as liver autotransplantation, is a hybrid (cross-fertilized) surgery incorporating the technical knowledge from extreme liver and transplant liver surgeries, and recently became more embraced and popularized among leading centers. ELS could be summarized into three major categories, namely, ex-situ liver resection and autotransplantation (ELRA), ante-situm liver resection and autotransplantation (ALRA) and auxiliary partial liver autotransplantation (APLA). The successful development of ELS during the past 37 years is definitely inseparable from continuous efforts done by Chinese surgeons and researchers.

Ask Less, Learn More: Adapting Ecological Momentary Assessment Survey Length by Modeling Question-Answer Information Gain.

Ecological momentary assessment (EMA) is an approach to collect self-reported data repeatedly on mobile devices in natural settings. EMAs allow for temporally dense, ecologically valid data collection, but frequent interruptions with lengthy surveys on mobile devices can burden users, impacting compliance and data quality. We propose a method that reduces the length of each EMA question set measuring interrelated constructs, with only modest information loss.

Electric Field-Enhanced SERS Detection Using MoS-Coated Patterned Si Substrate with Micro-Pyramid Pits.

This study utilized semiconductor processing techniques to fabricate patterned silicon (Si) substrates with arrays of inverted pyramid-shaped micro-pits by etching. Molybdenum trioxide (MoO) was then deposited on these patterned Si substrates using a thermal evaporation system, followed by two-stage sulfurization in a high-temperature furnace to grow MoS thin films consisting of only a few atomic layers. During the dropwise titration of Rhodamine 6G (R6G) solution, a longitudinal electric field was applied using a Keithley 2400 (Cleveland, OH, USA) source meter.

Exploring the Effectiveness and Challenges of Community Rehabilitation Service Programs for Children with Developmental Delays: A Qualitative Study from the Perspective of Early Intervention Service Providers in Taiwan.

This qualitative study aimed to investigate the effectiveness of community rehabilitation programs for children with developmental delays from the perspective of early intervention service providers in Taiwan. Adopting a single-case experimental design (ABM design), this study examined the immediate and sustained effects of interventions on individualized goals during baseline, intervention, and maintenance phases. Additionally, data from interviews with parents, special education teachers, and other participants were collected to understand the challenges and improvement strategies of community rehabilitation programs.

Risk Factors Related to Postoperative Dizziness Among Patients Who Underwent General Anesthesia and Intraoperative Analgesics: A Prospective Cohort Study.

Purpose: To describe postoperative dizziness for patients who received analgesics during general anesthesia and to investigate the factors related to the trend of dizziness within 3 days after surgery.

Design: A prospective cohort study.

Methods: This is a longitudinal study.

[Temporal and Spatial Evolution and Prediction of Ecosystem Carbon Storage in Jiangxi Province Based on PLUS-InVEST Model].

Land-use changes are an important factor affecting the change in carbon storage in terrestrial ecosystems. Exploring the relationship between land-use changes and carbon storage provides reliable data support for optimizing regional land-use structure and maintaining regional carbon balance. Taking Jiangxi Province as an example, we first analyzed the land-use changes; then simulated the land-use pattern under three scenarios (i.

Macrophages as Targets in Hepatocellular Carcinoma Therapy.

Hepatocellular carcinoma (HCC) is a malignant tumor with a complex and diverse immunosuppressive microenvironment. Tumor-associated macrophages (TAM) are an essential component of the tumor immune microenvironment. TAMs typically exist in two primary states: anti-tumor M1 macrophages and protumor M2 macrophages.

Retraction: Down-regulation of MRPS23 inhibits LPS-induced proliferation and invasion regulation of the NF-κB signaling pathway in osteosarcoma cells.

[This retracts the article DOI: 10.1039/C8RA08973F.].

Facets of impulsivity and reward in relation to binge-eating disorder course of illness among children: findings from the Adolescent Brain Cognitive Development study.

Background: The present study examined facets of impulsivity and reward sensitivity [as measured by the UPPS-P Impulsive Behavior Scale and Behavioral Activation and Behavioral Inhibition Scales (BIS/BAS)] as multivariable predictors of subsequent binge-eating disorder (BED) course of illness in middle childhood.

Methods: The current sample included children aged 9-10 years (N = 9,438) who took part in the baseline and 1-year follow-up assessments of the Adolescent Brain Cognitive Development (ABCD) study. BED course was operationalized as those who never developed BED or subthreshold BED (SBED) ('control'), were diagnosed with BED/SBED at year 1 but not baseline ('developers'), were diagnosed with BED/SBED at baseline but not year 1 ('remitters'), or were diagnosed with BED/SBED at both times ('maintainers').

Switch/Sucrose Non-Fermentable Complex-Deficient Rhabdoid Carcinoma of Stomach: A Rare Case Report and Literature Review.

Gastric undifferentiated/rhabdoid carcinoma is a rare highly invasive tumor of epithelial origin. Due to mutations in the switch/sucrose non-fermentable (SWI/SNF) complex, these tumor cells are usually dedifferentiated, presenting a characteristic rhabdoid profile. In this report, we present a gastric rhabdoid carcinoma in a 77-year-old man who presented with intermittent epigastric pain.

Analysis of high risk factors for chronic atrophic gastritis.

Background: Screening for chronic atrophic gastritis (CAG) is crucial for the prevention and early detection of gastric cancer. Endoscopy is the main method of CAG diagnosis, with high training requirements and limited accuracy, making it difficult to popularize. The study attempts to improve the positive rate and accuracy of CAG screening through non-invasive testing.

Pemigatinib in previously treated Chinese patients with locally advanced or metastatic cholangiocarcinoma carrying FGFR2 fusions or rearrangements: A phase II study.

Objective: This study evaluated the antitumor activity and safety of pemigatinib in previously treated Chinese patients with advanced cholangiocarcinoma and fibroblast growth factor receptor 2 (FGFR2) fusions or rearrangements.

Background: Pemigatinib provided clinical benefits for previously treated patients with cholangiocarcinoma carrying FGFR2 fusions or rearrangements and was approved for this indication in multiple countries.

Methods: In this ongoing, multicenter, single-arm, phase II study, adult patients with locally advanced or metastatic cholangiocarcinoma carrying centrally confirmed FGFR2 fusions or rearrangements who had progressed on ≥1 systemic therapy received 13.

Hepatocellular carcinoma-derived exosomal miRNA-761 regulates the tumor microenvironment by targeting the SOCS2/JAK2/STAT3 pathway.

Background: Exosomes and exosomal microRNAs have been implicated in tumor occurrence and metastasis. Our previous study showed that microRNA-761 (miR-761) is overexpressed in hepatocellular carcinoma (HCC) tissues and that its inhibition affects mitochondrial function and inhibits HCC metastasis. The mechanism by which exosomal miR-761 modulates the tumor microenvironment has not been elucidated.