A Natural TMEM16A Inhibitor with Conformational Lock Mechanism: Thymol Reverses Secretory Diarrhea via Chloride Flux Regulation and Antiinflammatory.

Secretory diarrhea is characterized by excessive production of electrolytes and water by intestinal epithelial cells, resulting in persistent watery stools. This study suggested that abnormal activation of TMEM16A might contribute to its pathogenesis. A drug screening identified thymol, a natural product, as a significant inhibitor of TMEM16A channel activity.

Vertical directional coupling based grating emission engineering for optical phased arrays: publisher's note.

This publisher's note contains a correction to Opt. Lett.49, 3102 (2024)10.

Vertical directional coupling based grating emission engineering for optical phased arrays.

In this Letter, a novel, to the best of our knowledge, vertical directional coupling waveguide grating (VDCWG) architecture is proposed to increase the length of waveguide grating antennas for large aperture on-chip optical phased arrays (OPAs). In this new architecture, the grating emission strength is engineered by the vertical directional coupler, which provides additional degrees of design freedom. Theoretical analysis and numerical simulation show that the VDCWG can adjust the grating strength in the range of more than two orders of magnitude, corresponding to an effective grating length more than a centimeter.