Pharmacokinetics and Biodistribution of Polymeric Nanoparticles Loaded with a Small Molecule Drug in Mice with Alcoholic Liver Disease.

We recently demonstrated the therapeutic efficacy of a novel phosphodiesterase 4B (PDE4B) inhibitor, KVA-D88, loaded in mPEG--P(CB--LA) polymeric nanoparticles (NPs) for alcohol-associated liver disease (AALD) treatment. In this study, we investigated the pharmacokinetics (PK) parameters and biodistribution at whole body and organ (liver) levels of this nanoformulation compared to the KVA-D88 free drug as well as their in vivo efficacies. Following administration, KVA-D88 was distributed to all major organs, with the highest accumulation in the liver and kidney and the lowest accumulation in the brain when loaded into NPs, as quantified using LC-MS/MS after a single intravenous injection in a mouse model with AALD induced by Lieber-DeCarli.

Correction: Bromelain: a review of its mechanisms, pharmacological effects and potential applications.

Correction for 'Bromelain: a review of its mechanisms, pharmacological effects and potential applications' by Virender Kumar , , 2023, , 8101-8128, https://doi.org/10.1039/D3FO01060K.

Protein-tags and their fragments as potent inhibitors of enzymes: Structure of the ternary complex of phosphopantetheine adenylyltransferase from Enterobacter spp. with tag-peptides and phosphonoacetic acid at 2.20 Å resolution.

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step of coenzyme A (CoA) biosynthesis pathway by transferring the adenylyl group from adenosine triphosphate (ATP) to 4'-phosphopantetheine (PNS), yielding 3'-dephosphocoenzyme A and pyrophosphate. In this study, the recombinant PPAT from Enterobacter spp. strain 638 (EbPPAT) was purified and co-crystallized with phosphonoacetic acid (PAE).

Deciphering the role of monoacylglycerol lipases (MAGL) under abiotic stress and lipid metabolism in soybean (Glycine max L.).

Monoacylglycerol lipase (MAGL) is involved in the last step of triacylglycerol breakdown by hydrolysing the monoacylglycerol (MAG) to free fatty acid and glycerol. In the present study, 21 and 38 MAGL genes were identified in Glycine max (cultivated soybean) and Glycine soja (wild) genomes, respectively. Gene-specific association performed using whole genome resequencing data by mixed linear model showed a significant association with total seed oil, linolenic, and oleic acid content.

Evaluation of Efficacy of Tranexamic Acid on Blood Loss in Surgically Managed Intertrochanteric Fractures.

Introduction: Intertrochanteric (IT) fracture surgeries make up a significant portion of trauma operations worldwide. The routine use of tranexamic acid (TXA) for these surgeries is not common in current practice at most places. This prospective study evaluated its efficacy in reducing perioperative blood loss and accentuating its potential for a better outcome.

Transforming healthcare: the impact of artificial intelligence on diagnostics, pharmaceuticals, and ethical considerations - a comprehensive review.

Interpretability of results remains challenging in most health industries since patients may suffer life-threatening consequences from an inaccurate diagnosis. Artificial intelligence (AI) integration has arisen as a prominent technology in the healthcare sector, transforming the field by advancing early diagnostics, surgeries, and ethical concerns. The present review analyzes the multidimensional impact of AI on the health sector through enhancements in medical accuracy and diagnosis outcomes.

Efficient Bioprocess for Mixed PET Waste Depolymerization Using Crude Cutinase.

In recent years, several plastic-degrading enzymes with efficient depolymerization abilities for PET have been reported. Here, we report a bioprocess for mixed PET waste depolymerization using crude extracellularly expressed enzymes in . The enzymes, namely FastPETase, LCC, and LCC, were screened to depolymerize amorphous PET powder and films of different sizes and crystallinity.

Enhancing alopecia areata management: Nanocrystal-driven strategy for targeting hair follicles.

Alopecia areata (AA) is an autoimmune disorder that disrupts the hair growth cycle, leading to non-scarring hair loss. In AA, hair follicles (HFs) serve as both pathological targets and potential drug delivery sites when treated with optimized topical formulations. This study investigates the follicular targeting efficiency of clobetasol-17-propionate (CP) nanocrystal (CP-NC) suspension, a nanoformulation designed to enhance the efficacy of conventional CP therapies by improving kinetic solubility and creating a steep concentration gradient that promotes passive dermal penetration.

On the Environmentally Friendly Synthesis of 2-Hydroxyethyl Furan-5-Carboxylic Acid (MHEF) and bis(2-Hydroxyethyl) Furan-2,5-Dicarboxylate (BHEF).

To better understand how the biocatalyzed depolymerization of polyesters works, model molecules are needed to develop activity assays and determine enzymatic kinetic parameters. In this communication the chemical synthesis and characterization of 2-hydroxyethyl furan-5-carboxylic acid and bis(2-hydroxyethyl) furan-2,5-dicarboxylates as potential model molecules to further study the enzymatic depolymerization of poly(ethylene furanoate) was investigated.

Incredible use of plant-derived bioactives as anticancer agents.

Cancer is a major global concern. Despite considerable advancements in cancer therapy and control, there are still large gaps and requirements for development. In recent years, various naturally occurring anticancer drugs have been derived from natural resources, such as alkaloids, glycosides, terpenes, terpenoids, flavones, and polyphenols.

Potential Role of TIP3 Aquaporins in the Transport of HO and Boric Acid During Seed Development and Germination in Soybean (Glycine max L.).

Tonoplast intrinsic proteins (TIPs) are the channel-forming proteins predominantly found in the tonoplast of plant cells. Despite the identification of TIPs in numerous plant species, very less is known about the precise role of different TIP subgroups. In the present study, two genes belonging to the TIP3 subgroup were studied to understand tissue-specific role and solute transport activity.

Exploration of advanced omics tools and resources for the improvement of industrial oil crops.

The rapid advancement in the field of omics approaches plays a crucial role in the development of improved industrial oil crops. Industrial oil crops are important for many sectors like food processing, biofuels, cosmetics, and pharmaceuticals, making them indispensable contributors to global economies and these crops serve as vital elements in a multitude of industrial processes. Significant improvements in genomics have revolutionized the agricultural sector, particularly in the realm of oil crops.

Effect of conservation agriculture on soil fungal diversity in rice-wheat-greengram cropping system in eastern Indo-Gangetic plains of South Asia.

Introduction: Conservation agriculture (CA) is emerging as an eco-friendly and sustainable approach to food production in South Asia. CA, characterized by reduced tillage, soil surface cover through retaining crop residue or raising cover crops, and crop diversification, enhances crop production and soil fertility. Fungal communities in the soil play a crucial role in nutrient recycling, crop growth, and agro-ecosystem stability, particularly in agricultural crop fields.

Anti-CLL1 liposome loaded with miR-497-5p and venetoclax as a novel therapeutic strategy in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a lethal hematologic malignancy. Chemotherapy resistance results in a dismal survival rate of 1-2 years in older adults with AML. Therefore, novel therapies are urgently required.

Context-dependent agricultural intensification pathways to increase rice production in India.

Yield gap analysis is used to characterize the untapped production potential of cropping systems. With emerging large-n agronomic datasets and data science methods, pathways for narrowing yield gaps can be identified that provide actionable insights into where and how cropping systems can be sustainably intensified. Here we characterize the contributing factors to rice yield gaps across seven Indian states, with a case study region used to assess the power of intervention targeting.

Anticancer Potential of Pineapple and its Bioactive Compound Bromelain.

Various ailments have been treated with pineapple ( (L.) Merr.) throughout medicinal history.

A Multicenter Phase II Trial of Ruxolitinib for Treatment of Corticosteroid Refractory Sclerotic Chronic Graft-Versus-Host Disease.

Purpose: Sclerotic chronic graft-versus-host disease (cGVHD) represents a highly morbid and refractory form of cGVHD, and novel therapies for sclerotic cGVHD are critically needed. This study aimed to determine the efficacy of ruxolitinib in patients with corticosteroid refractory sclerotic cGVHD.

Patients And Methods: In a single-arm multicenter phase II trial (N = 47), adults with sclerotic cGVHD refractory to corticosteroids and ≥one additional line of systemic therapy for cGVHD received ruxolitinib for ≥six months (ClinicalTrials.

Antioxidants for Skin Health.

Antioxidants play a pivotal role in maintaining skin health and integrity, combating the deleterious effects of oxidative stress induced by environmental aggressors such as UV ra-diation, pollution, and lifestyle factors. This paper reviews the contributions of key antioxidants, including Vitamin C, Vitamin E, Vitamin A, green tea extract, Coenzyme Q10, Resveratrol, Selenium, and Polyphenols, in skin health care. Vitamin C, known for its collagen synthesis promotion and photoprotection properties, alongside Vitamin E, a lipid-soluble antioxidant, syn-ergistically works to neutralize free radicals and repair damaged skin cells.

Efficient Depolymerization of Poly(ethylene 2,5-furanoate) Using Polyester Hydrolases.

Poly(ethylene 2,5-furanoate) (PEF) is considered to be the next-generation green polyester and is hailed as a rising star among novel plastics. It is biobased, is nontoxic, and has comparable or improved properties compared to polyethylene terephthalate (PET). Biobased PEF offers lower life-cycle greenhouse gas emissions than PET.

A novel phosphodiesterase inhibitor for the treatment of chronic liver injury and metabolic diseases.

Background And Aims: Chronic liver disease leads to ~2 million deaths annually. Cyclic AMP (cAMP) signaling has long been studied in liver injury, particularly in the regulation of fatty acid (FA) β-oxidation and pro-inflammatory polarization of tissue-resident lymphocytes. Phosphodiesterase 4B inhibition has been explored as a therapeutic modality, but these drugs have had limited success and are known to cause significant adverse effects.

Recent advances, challenges and updates on the development of therapeutics for malaria.

Malaria has developed as a serious worldwide health issue as a result of the introduction of resistant species strains. Because of the common chemo resistance to most of the existing drugs on the market, it poses a severe health problem and significant obstacles in drug research. Malaria treatment has evolved during the last two decades in response to drug sensitivity and a return of the disease in tropical areas.

Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health.

Although the liver is the largest metabolic organ in the body, it is not alone in functionality and is assisted by "an organ inside an organ," the gut microbiota. This review attempts to shed light on the partnership between the liver and the gut microbiota in the metabolism of macronutrients (i.e.

Effect of Organic and Inorganic Nanoparticles on Colour Stability and Mechanical Properties of Heat Vulcanised Maxillofacial Silicone Elastomer: a Comparative Study.

Objectives: The purpose of this comparative study was to evaluate the effect of organic and inorganic nanoparticles on colour stability, tear strength and hardness of maxillofacial silicone elastomer at baseline and when subjected to outdoor weathering for 6 months.

Material And Methods: A total of 240 specimens were fabricated using M511 platinum silicone which were divided into total 4 groups (n = 60) based on the type of nanoparticles (control, polytetrafuoroethylene [PTFE], titanium dioxide [TiO], zinc oxide [ZnO]) added and each group was further divided into 3 subgroups (n = 20) for colour, tear strength (TS) and hardness (H) testing. The tests were conducted and data was obtained both before and after outdoor weathering of 6 months.