Obesity Selectively Increases Intraoperative Risk in Left-Sided Colon Cancer Surgery: A Retrospective Cohort Study.

Background: Obesity is traditionally viewed as a risk factor for adverse surgical outcomes. This study evaluated whether obesity (BMI ≥ 30 kg/m) independently affected intraoperative and postoperative outcomes following colon cancer resection, and whether these effects varied by anatomical site.

Methods: A retrospective cohort study was conducted of consecutive patients who underwent colon cancer resection at a single institution from 2015 to 2022.

Obesity and gastrointestinal cancer: A converging epidemic with surgical consequence.

Obesity is now a recognised carcinogen with growing implications for gastrointestinal surgical oncology. Excess adiposity promotes tumourigenesis through endocrine, inflammatory, and mechanical pathways, contributing to increased cancer incidence, stage at diagnosis, and worse oncological outcomes. For patients undergoing gastrointestinal cancer surgery, obesity adds significant technical complexity and elevates perioperative morbidity.

Doppler-Guided Haemorrhoidal Artery Ligation and Rectoanal Repair (HAL-RAR): An Institutional Experience.

: Doppler-guided haemorrhoidal artery ligation with rectoanal repair (HAL-RAR) is a minimally invasive alternative to conventional haemorrhoidectomy. While associated with reduced postoperative pain and quicker recovery, data on its safety, recurrence rates, and applicability across haemorrhoid grades remain limited, particularly in Australian settings. : A retrospective review was conducted on 128 consecutive patients who underwent elective HAL-RAR at a single institution between February 2022 and December 2024.

The Impact of Obesity on Intraoperative Complications in Rectal Cancer.

Background: Obesity is a growing global health concern and poses significant challenges in rectal cancer surgery. Excess visceral fat can obscure surgical landmarks, complicate dissection, and increase the risk of intraoperative adverse events (iAEs). Despite these recognized difficulties, there is limited objective data quantifying the impact of obesity on intraoperative complications.

Safety and efficacy of gastrointestinal motility agents following elective colorectal surgery: a systematic review and meta-analysis of randomised controlled trials.

Background: Postoperative ileus (POI) is a frequent complication after elective colorectal surgery, delaying gastrointestinal (GI) recovery and discharge. While pharmacologic agents such as laxatives and prokinetics are often included in enhanced recovery after surgery (ERAS) protocols, their efficacy and safety remain uncertain.

Methods: A systematic review and meta-analysis of randomised controlled trials (RCTs) was conducted to evaluate the effect of Gastrointestinal (GI) motility agents on postoperative recovery in elective colorectal surgery.

Discovery of WEE1 Kinase Inhibitors with Potent Activity against Patient-Derived, Metastatic Colorectal Cancer Organoids.

A library of potent WEE1 kinase inhibitors was synthesized based on the discontinued frontrunner clinical candidate AZD1775 (), many of which were more selective for WEE1 over an undesirable off-target of , the kinase PLK1. When tested against patient-derived organoids (PDOs) grown from -mutated colorectal cancer (CRC) peritoneal metastases, (IC value of 62 nM) exhibited stronger efficacy than (IC value of 120 nM) and the best-in-class clinical candidate ZN-c3 (IC value of 127 nM). Against primary CRC PDOs with -WT, significantly enhanced DNA damage, replication stress and apoptosis compared to , as well as demonstrated high selectivity over patient-matched normal healthy colon PDOs, highlighting a potential therapeutic window for cancer treatment.

Right hemicolectomy for colon cancer: does the anastomotic configuration affect short-term outcomes?

Objectives: Right hemicolectomy is a common colorectal operation for resection of cancers of the right colon. The ileocolic anastomosis may be created using a stapled end-to-side, stapled side-to-side or handsewn technique. Anastomotic leak and post-operative bleeding are uncommon but serious causes of morbidity and mortality, while post-operative ileus contributes to prolonged length of stay.

Surgical management of splenic flexure cancer: is there an optimal technique? A bi-national registry analysis.

Background: Splenic flexure tumours (SFC) are uncommon and present at more advanced disease stages. The optimal surgical technique for SFC remains controversial. We sought to compare the short-term outcomes of a left hemicolectomy (LHC) versus an extended resection (subtotal colectomy, STC) for SFCs.

Mechanical bowel preparation with pre-operative oral antibiotics in elective colorectal resections: an Australian single institution experience.

Background: Anastomotic leaks (AL) and surgical site infections (SSI) are serious complications after colorectal resection. Studies have shown the benefits of pre-operative oral antibiotics (OAB) with mechanical bowel preparation (MBP) in reducing AL and SSI rates. We aim to investigate our experience with the short-term outcomes of AL and SSI following elective colorectal resections in patients receiving OAB with MBP versus MBP only.

Does intra-operative humidification with warmed CO reduce surgical site infection in open colorectal surgery? A randomized control trial.

Backgrounds: Surgical site infections (SSI) are a significant cause of postoperative morbidity and mortality, contributing to a considerable financial burden on the healthcare system. Insufflation of the open surgical wound with warm, humidified carbon dioxide (CO ) is a novel measure aimed to reduce SSI. The local atmosphere of warm, humidified CO within the open surgical wound is proposed to decrease airborne contamination, bacterial growth, desiccation, and heat loss while improving tissue oxygenation and perfusion.

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases in an elderly population: outcomes from a single centre.

Background: The prevalence of elderly patients with resectable colorectal peritoneal metastases (CRPM) is increasing. This study aimed to compare short and long-term outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRPM in patients above and below 70 years of age.

Methods: This was a retrospective, 10-year analysis of 90-day major morbidity and mortality, and long-term survival.