Mild Parkinsonian Signs and Incidence of Motoric Cognitive Risk Syndrome in Older Adults.

Objective: We aimed to compare the incidence of motoric cognitive risk syndrome (MCR)-a pre-dementia syndrome that is identified by a combination of slowed gait speed and cognitive complaints-and previous mild parkinsonian signs (MPS) in older adults without Parkinson disease who do not have dementia.

Design: Prospective cohort study.

Setting And Participants: The study included community-dwelling older individuals (≥65 years) who did not have MCR at baseline.

Affective Symptoms and Amyloid Plaques: Antidepressant Response and Clinical Outcome Associated With Brain Amyloid Load in a 2-Year Cohort of Nondemented Older Adults With Depression-The ASAP Study.

Objectives: The ASAP study investigated whether amyloid load in the brain would be associated with poor antidepressant response in the short term (8 weeks) and worse clinical outcomes (remission status) in the long term (2 years).

Methods: Nondemented older adults with non-treatment-resistant depression were enrolled in an 8-week observational study to assess the relationship between amyloid load and antidepressant response and subsequently followed for 2 years. Amyloid load was measured using F-Florbetapir Positron Emission Tomography scans, and treatment response was evaluated using the Montgomery-Åsberg Depression Rating Scale.

Is the FAB test associated with fall occurrence in older adults? A retrospective analysis of outpatient fall risk assessment.

Methods: We conducted a single-center, retrospective cohort study of French older adults. Participants with Mini-Mental State Examination (MMSE) ≥ 24 were recruited from a fall clinic in a geriatrics department. We recorded history of falls in the preceding 6 months, as well as Timed Up and Go test and mobility assessment at baseline and at 6- and 12-month follow-up.

Support for Nursing Home Caregivers During the COVID-19 Pandemic: A Review.

Purpose: To review support systems for nursing home caregivers (NHCGs) that were implemented during the first year of the coronavirus disease 2019 (COVID-19) pandemic.

Method: Database searches in PubMed, ScienceDirect, and CINAHL resulted in five publications.

Results: Studies differed in design, interventions, and outcomes.

Impact of influenza immunity on the mortality among older adults hospitalized with COVID-19: a retrospective cohort study.

It has been suggested that the outcomes of coronavirus disease 2019 (COVID-19) are better in individuals having recently received an influenza vaccine than in non-vaccinated individuals. We hypothesized that this association depends on the humoral responses against influenza viruses. We aim to assess the relationship between the humoral immunity against influenza and the 3-month all-cause mortality among hospitalized older patients with COVID-19.

Digital health technologies and Alzheimer's disease clinical trials: might decentralized clinical trials increase participation by people with cognitive impairment?

Background: Therapeutic trials in Alzheimer's disease (AD) face many obstacles-particularly with regard to screening and recruitment.

Discussion: Decentralized clinical trials (DCTs) are being developed in other diseases and appear to be of value for overcoming these difficulties. The use of remote visits offers hope of broader recruitment and thus a reduction in inequalities due to age, geography, and ethnicity.

The Nebulous Association between Cognitive Impairment and Falls in Older Adults: A Systematic Review of the Literature.

Background: In older people, dementia is a well-established risk factor for falls. However, the association and the causal relationship between falls and the earlier stages of cognitive impairment remains unclear. The purpose of the study was to review the literature data on the association between falls and cognitive impairment, no dementia, including Mild Cognitive Impairment.

What Tools Can We Use to Screen for Fall Risk in Older Patients with Mild Cognitive Impairment? Findings from the MEMENTO Cohort.

Objectives: Identifying risk factors for falls can improve outcomes in older patients without cognitive decline. Yet this has not been demonstrated in older people with mild cognitive impairment (MCI). We therefore sought to better identify risk factors for falls in this particular group.

High Prevalence of Geriatric Conditions Among Older Adults With Cardiovascular Disease.

As the population ages, the global cardiovascular disease burden will continue to increase, particularly among older adults. Increases in life expectancy and better cardiovascular care have significantly reshaped the epidemiology of cardiovascular disease and have created new patient profiles. The combination of older age, multiple comorbidities, polypharmacy, frailty, and adverse noncardiovascular outcomes is challenging our routine clinical practice in this field.

Neuroinflammation: A Possible Link Between Chronic Vascular Disorders and Neurodegenerative Diseases.

Various age-related diseases involve systemic inflammation, i.e. a stereotyped series of acute immune system responses, and aging itself is commonly associated with low-grade inflammation or inflamm'aging.

Is Fall Risk Systematically Evaluated in Memory Clinics? A National Survey of Practice in France.

Background: Falls are a major health problem in older persons but are still under-diagnosed and challenging to prevent. Current guidelines do not target high-risk populations, especially people living with dementia. In France, people with neurocognitive disorders are mainly referred to memory clinics (MCs).