Publications by authors named "Francois Puisieux"

The aim of this study is to assess the prevalence of diabetes in patients attending a multidisciplinary consultation for fall risk assessment and to compare fall risk factors and the prevalence of other geriatric syndromes in patients with and without diabetes. A single-center retrospective cohort study was conducted at the Lille University Hospital Geriatrics Department, France. Inclusion criteria were any patients aged 65 years and over consulting for fall risk assessment between January 2, 2005, and January 2, 2015.

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Although the use of direct oral anticoagulants increases in parallel with the increase in atrial fibrillation (AF) with age, none of the bleeding risk scores (HAS-BLED, HEMORR2HAGES, ATRIA nor RE-LY) have been developed in a geriatric population. Our study aimed to develop a bleeding risk score adapted to this specific population and this therapeutic class. Multicentre, longitudinal, prospective, observational, pharmacoepidemiologic study conducted in 60 French cardiologic and geriatric centres included consecutive patients aged ≥80 years with AF, treated with rivaroxaban and followed for at least 1 year.

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Aims: The French government's IATROPREV program has been designed to assess the effectiveness and safety of medications prescribed to older adults discharged from acute geriatric units. IATROPREV includes the implementation of a personalized pharmaceutical plan validated at a multidisciplinary meeting attended by the patient's geriatrician, family physician, community pharmacist and hospital pharmacist. We hypothesized that a multidisciplinary meeting on discharge from hospital will enable the recommendations to be largely followed up.

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Introduction: End-of-life management in acute geriatric units (AGUs) is frequent but complex. Midazolam is the drug of choice for the management of refractory symptoms (particularly in the context of sedation) at the end of life. The objective of the present ambispective analysis was to investigate the frequency and modalities of midazolam use for palliative care in AGUs in France.

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The First French Fall Prevention Day for Elderly People took place in Montpellier on October 1, 2024. This event highlighted the elderly people's interest in: i) public conference providing information on fall risk factors and general preventive measures; ii) workshops across the metropolitan area offering individual fall risk assessments, personalized advice based on identified risk levels and factors. It also highlighted healthcare professionals and training institutes interest in: i) information on the roles of various field actors in the care pathway for older individuals at moderate or high fall risk; ii) new organizational models and technologies developed to implement national and global fall prevention recommendations.

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Objectives: To easily detect frailty in a timely fashion, enabling targeted interventions and appropriate monitoring, will be a major worldwide public health and economic challenge as the proportion of older people increases in the population. Based on a review and meta-analysis showing that C-reactive protein (CRP), haemoglobin, albumin and vitamin D are associated with frailty, we aimed to develop and validate a biological score using these biomarkers for the detection of frailty.

Design: We conducted a retrospective, cross-sectional, monocentric study using the electronic healthcare database of Lille University Hospital, France.

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Monitoring parasympathetic activity by the Analgesia Nociception Index (ANI) is reliable for assessing nociception during general anesthesia or in sedated critically ill patients. The aim of our study is to evaluate the variability of the ANI during painful procedures in noncommunicative patients at the end of life (EOL). This study was a blinded, prospective, observational study.

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Methods: We conducted a single-center, retrospective cohort study of French older adults. Participants with Mini-Mental State Examination (MMSE) ≥ 24 were recruited from a fall clinic in a geriatrics department. We recorded history of falls in the preceding 6 months, as well as Timed Up and Go test and mobility assessment at baseline and at 6- and 12-month follow-up.

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The personalized prescription plan (PPP) summarizes the changes made to a patient's prescription on discharge from hospital. The aim of the present study was to evaluate 30-day medication continuity in older patients whose PPP was implemented at hospital discharge. Prospective randomized controlled trial including people aged at least 75 discharged from an acute geriatric unit.

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Background: Understanding the nature and extent of sensorimotor decline in aging individuals and those with neurocognitive disorders (NCD), such as Alzheimer's disease, is essential for designing effective music-based interventions. Our understanding of rhythmic functions remains incomplete, particularly in how aging and NCD affect sensorimotor synchronization and adaptation to tempo changes.

Objective: This study aimed to investigate how aging and NCD severity impact tapping to metronomes and music, with and without tempo changes.

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Article Synopsis
  • - The CARENFER PA study aimed to assess the prevalence of iron deficiency (ID) in older patients (over 75 years) in geriatric units, finding a high ID prevalence of 57.6% among 888 patients studied.
  • - The study revealed that ID was more common in patients with multiple comorbidities and elevated levels of inflammation, as indicated by CRP levels, with CRP being a strong predictor of ID.
  • - Additionally, older patients with ID performed worse on the Short Physical Performance Battery (SPPB) test, indicating a higher risk of adverse outcomes such as disability and falls compared to those without ID.
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Background: Falls and fall-related injuries are a major public health problem in industrialized countries. Faced with this challenge, a French national plan was launched in 2022 aiming to reduce by 20% the incidence of falls-related hospitalizations or deaths.

Objectives: To describe the main pillars of the 2022-2024 French national plan against falls in older persons.

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Background: Falls and fall-related injuries are common in older adults, have negative effects on functional independence and quality of life and are associated with increased morbidity, mortality and health related costs.

Objective: To synthesize evidence-based and expert consensus-based 2022 world guidelines for the management and prevention of falls in older adults. These recommendations consider a person-centred approach that includes the preferences of the patient, caregivers and other stakeholders, gaps in previous guidelines, recent developments in e-health and both local context and resources.

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Background: In older people, dementia is a well-established risk factor for falls. However, the association and the causal relationship between falls and the earlier stages of cognitive impairment remains unclear. The purpose of the study was to review the literature data on the association between falls and cognitive impairment, no dementia, including Mild Cognitive Impairment.

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Objectives: Identifying risk factors for falls can improve outcomes in older patients without cognitive decline. Yet this has not been demonstrated in older people with mild cognitive impairment (MCI). We therefore sought to better identify risk factors for falls in this particular group.

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Background: Acute geriatric units (AGUs) require efficient discharge planning tools. Risk factors for discharge from an AGU to post-acute care (PAC) have not previously been investigated in detail.

Methods: The objective is to identify risk factors for PAC transfer.

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The importance of the discharge summary (DS) is well recognized. The format to be used is also important, but this aspect has not yet been studied in the literature. The purpose of this work was to establish a DS format for older patients that ensures effective communication with general practitioners (GPs).

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The successful design of musical interventions for dementia patients requires knowledge of how rhythmic abilities change with disease severity. In this study, we tested the impact of the severity of the neurocognitive disorders (NCD) on the socioemotional and motor responses to music in three groups of patients with Major NCD, Mild NCD, or No NCD. Patients were asked to tap to a metronomic or musical rhythm while facing a live musician or through a video.

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Article Synopsis
  • This study explored the effectiveness of the BNT162b2 booster vaccine on neutralizing antibodies and T cell responses in healthcare workers against the Omicron sublineages BA.1 and BA.2, before and three months after vaccination.
  • Results showed that before the booster, a small percentage of participants had measurable neutralizing activity, but by three months post-booster, nearly all had developed strong antibody responses against Delta and Omicron variants, although the levels were lower for BA.1 and BA.2 than for Delta.
  • Participants with recent SARS-CoV-2 infections maintained stable antibody levels, while those without infections experienced a decrease in neutralizing antibody titres over the three-month period.
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Background: Dementia has a negative impact on the quality of life of the person with dementia and their spouse caregivers, as well as on the couple's relationship, which can lead to high levels of distress for both partners. Hypnosis has been shown to be effective in managing distress and increasing the quality of the relationship.

Objective: The aim was to develop a standardized hypnosis intervention for couples confronted with Alzheimer's disease and evaluate its feasibility, acceptability, and helpfulness in managing the distress of both partners and increasing the quality of the relationship.

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Article Synopsis
  • Comfort care improves the quality of life for dying patients, and the study focused on how often patients in acute geriatric units (AGUs) transition to this type of care and its relation to different end-of-life trajectories.
  • In a sample of 177 patients, 69.5% transitioned to comfort care, with frailty being the most common condition affecting end-of-life decisions, especially in patients with dementia.
  • The findings suggest that while transitioning to comfort care is common in AGUs and related to various end-of-life trajectories, frailty without dementia does not significantly increase the likelihood of this transition, indicating a need for improved practices among healthcare providers.
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Background: The present study aimed to evaluate the persistent immunogenicity offered by a third dose of BNT162b2 against Delta and Omicron variants, in nursing home (NH) residents.

Methods: In this monocenter prospective observational study, anti-spike IgG levels, S1 domain reactive T cell counts, serum neutralizing antibody titers against Delta and Omicron variants were compared before and up to three months after the BNT162b2 booster dose, in NH residents without COVID-19 (COVID-19 naive) or with COVID-19 prior to initial vaccination (COVID-19 recovered).

Findings: 106 NH residents (median [interquartile range] age: 86·5 [81;91] years) were included.

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Introduction: Osteoporosis in older men is common and causes significant mortality and morbidity. Some data suggest that conditions leading to bone fragility, including osteoporosis, are under-identified and undertreated in men. Additionally, 50% of the causes of osteoporosis are secondary in men.

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