Analysis of disease burden and trends in non-COVID-19 respiratory infections in China (1990-2021).

Background: Following the outbreak of the coronavirus disease (COVID-19) in 2019, there was a lack of systematic data on the disease burden and epidemiological trends of respiratory infections in China.

Methods: A systematic analysis of the 2021 Global Burden of Disease Study was conducted to estimate the incidence, mortality, and disability-adjusted life years of upper respiratory infections (URIs) and lower respiratory infections (LRIs) in China. These estimates were stratified according to sex and age.

Global, regional, and national multiple myeloma burden from 1990 to 2021: a systematic analysis for of the Global Burden of Disease Study 2021.

Background: Multiple myeloma (MM) is the second most common haematological malignancy worldwide. A comprehensive global analysis of MM based on diverse geographic locations and timeframes is lacking. This study aimed to provide the incidence, mortality rate, and disability-adjusted life years (DALYs) of MM, from 1990 to 2021, focusing on the age structure and temporal trends of the disease burden.

Focal adhesion in the tumour metastasis: from molecular mechanisms to therapeutic targets.

The tumour microenvironment is the "hotbed" of tumour cells, providing abundant extracellular support for growth and metastasis. However, the tumour microenvironment is not static and is constantly remodelled by a variety of cellular components, including tumour cells, through mechanical, biological and chemical means to promote metastasis. Focal adhesion plays an important role in cell-extracellular matrix adhesion.