Publications by authors named "Tian-Hui Guo"
Non-small cell lung cancer (NSCLC) with EGFR mutations presents a unique challenge due to the development of oligometastasis during treatment with first-line tyrosine kinase inhibitors (TKIs). The optimal timing of radiotherapy in EGFR-mutant oligometastatic NSCLC remains debated. This study aims to investigate the timing of radiotherapy in relation to disease progression to optimize treatment outcomes.
View Article and Find Full Text PDFBackground And Objective: Tyrosine kinase inhibitors (TKIs) have revolutionized the treatment of epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC), improving survival significantly. However, the integration of TKIs with radiotherapy (RT) for oligometastatic EGFR-mutant NSCLC remains an emerging strategy, with questions surrounding the optimal timing of RT intervention. This review seeks to examine recent insights into the timing of RT in relation to disease progression and to investigate the radiosensitizing effects of TKIs.
View Article and Find Full Text PDFComputed tomography-based radiomic model for the prediction of neoadjuvant immunochemotherapy response in patients with advanced gastric cancer.
World J Gastrointest Oncol
October 2024
Background: Neoadjuvant immunochemotherapy (nICT) has emerged as a popular treatment approach for advanced gastric cancer (AGC) in clinical practice worldwide. However, the response of AGC patients to nICT displays significant heterogeneity, and no existing radiomic model utilizes baseline computed tomography to predict treatment outcomes.
Aim: To establish a radiomic model to predict the response of AGC patients to nICT.
Article Synopsis
- The study investigates how to improve immune checkpoint therapy effectiveness for soft tissue sarcoma (STS), particularly liposarcoma, by exploring combinations with histone deacetylase (HDAC) inhibitors.
- Whole-exome sequencing and analysis of somatic copy number alterations revealed frequent amplification of class I HDAC genes in patients, suggesting their role in poor prognosis for STS.
- The combination of the HDAC inhibitor chidamide with PD-1 blockade showed promising results in enhancing T cell activity and reducing tumor growth in mice, indicating potential for better treatments in advanced sarcoma patients.
Background: Unplanned excision (UPE) of soft tissue sarcoma (STS) is often chosen in the early phase by general physicians without any radiological evaluation.
Purpose: The present study aimed to evaluate the impact of UPE on the clinical outcomes of patients with STS of the trunk and extremity.
Materials And Methods: Patients with STS of the trunk and extremity who underwent R0 resection between 1998 and 2016 were included and divided into the UPE and planned excision (PE) groups.