() rs738409 Variant and Non-Alcoholic Fatty Liver Disease Risk in Vietnamese Working-Age Adults: A Case-Control Study with Metabolic Insights.

Background: Non-alcoholic fatty liver disease (NAFLD) is an increasing public health concern in Vietnam, particularly among working-age adults (18-60 years). The rs738409 variant (C>G) is a well-established risk factor for NAFLD globally; however, its impact on the Vietnamese population remains inadequately studied. This study investigates its association with NAFLD risk and its interaction with metabolic factors.

A prospective cohort study produces inconclusive results in linking dietary calcium intake to overall and specific causes of mortality.

Dietary calcium's role in human health and disease prevention is inconclusive. We examined the associations between dietary calcium intake and the risk of overall and specific causes of mortality. A prospective cohort study was performed for 42,146 individuals from 2008 to 2019.

Cumulative impacts of interbasin water transfer and salinity intrusion on water security in central Vietnam.

Saltwater intrusion poses a significant threat to freshwater availability in downstream regions globally, leading to economic losses, compromised water supply, reduced agricultural productivity, social instability, and environmental degradation. This study assesses the extent and drivers of salinity intrusion in the downstream areas of the Vu Gia Thu Bon River basin, central Vietnam, with a particular focus on Da Nang City. The analysis considers the impacts of upstream dam operations and inter-basin water transfers on water supply and irrigation, encompassing both direct and indirect damages.

Diagnosis of Zinner syndrome: A case of rare occurrence.

Zinner syndrome is a rare congenital urinary condition, secondary to disruptions in the embryonic development process between the fourth and 13th week of pregnancy, particularly due to abnormalities in the development of the distal mesonephric duct. It is characterized by the triad of unilateral renal agenesis, ipsilateral seminal vesicle cyst, and ipsilateral vas deferens obstruction. We present a case of a young male patient who came to the hospital for a health check-up.

Genetic Variant rs1801275 in Atopic Dermatitis: Prevalence and Clinical Implications in Vietnamese Population.

Background: Atopic dermatitis (AD), a chronic inflammatory skin condition, affects up to 20% of children and 10% of adults globally, driven by a type 2 immune response via IL-4 and IL-13 through IL-4Rα. The rs1801275 variant in gene, a glutamine-to-arginine substitution (Q576R), increases AD severity and atopic comorbidities. This study examines rs1801275's prevalence and clinical impact in Vietnamese population.

Urbanization and childhood asthma.

Childhood asthma is one of the major public health concerns, and urbanization as well as worsening environmental factors are contributing to its increasing prevalence. Outdoor pollutants, such as PM2.5, ozone, and traffic-related air pollution or TRAP, play significant roles in exacerbating asthmatic symptoms in children as well as reducing their lung function.

Initiating clozapine in the outpatient setting: A retrospective study examining the cost-effectiveness, feasibility and safety.

AimEvidence supporting an outpatient initiation model for clozapine is lacking and would add to prescriber, service and consumer confidence in the safety and benefits of this approach. Our study aims to determine whether outpatient initiation and titration of clozapine is feasible, safe and cost-effective in Australia.MethodsWe retrospectively identified 27 consumers aged 18-65 admitted to our service between 2007 and 2019 for day initiation and outpatient titration of clozapine.

Influence of Ultraviolet Light-Induced Photooxidation on the Surface Chemistry and Biodegradability of Aliphatic Polyamide Films.

This study examines the environmental degradation of polyamides (PAs) with varying methylene group content from the perspective of polymer surface chemistry. PA4, PA6, PA11, and PA12 films were subjected to ultraviolet (UV) exposure to simulate environmental photooxidation, and subsequent changes in surface morphology and wettability were analyzed using laser microscopy and contact angle measurements. After 4 weeks of UV exposure, PA11 and PA12, which contain longer alkylene chains, exhibited more pronounced and denser surface cracks than PA4 and PA6.

Characterization of an Emerging Recombinant Duck Circovirus in Northern Vietnam, 2023-2024.

This study aimed to characterize the duck circovirus circulating in Northern Vietnam based on complete genome sequences. Between 2023 and 2025, 45 pooled tissue samples were collected from nine duck flocks in several provinces in Northern Vietnam. Of the 45 samples tested, 16 (35.

Generalizable AI predicts immunotherapy outcomes across cancers and treatments.

Immune checkpoint inhibitors have become standard care across many cancers, but most patients do not respond. Predicting response remains challenging due to complex tumor-immune interactions and the poor generalizability of current biomarkers and models. Predictors such as tumor mutational burden, PD-L1 expression, and transcriptomic signatures often fail across cancer types, therapies, and clinical settings.

Seroprevalence of hepatitis A virus infection in urban and rural areas in Vietnam.

Background/objectives: The prevalence of hepatitis A virus (HAV) is associated with socioeconomic conditions, access to clean drinking water, and improvements in sanitation. In Vietnam, epidemiological data on HAV have been limited over the past two decades. This study aims to assess age-specific HAV seroprevalence across two distinct geographic regions, urban and rural areas, and identify the risk factors associated with HAV seropositivity in Vietnam.

A Novel Benzo[d]Thiazole Derivative as Selective Fluorescent Chemosensors for Al and Its AIE Properties.

A novel benzo[d]thiazole derivative (B31) was synthesized via a green method. Aggregation-induced emission (AIE) behavior was investigated in a dimethyl sulfoxide (DMSO)/water mixture. The solution of B31 exhibited fluorescence emission at approximately 500 nm with maximum intensity observed at 40% water content.

Optimizing Pediatric Asthma Management: Implementation and Evaluation of Anti-Inflammatory Reliever and Single Maintenance and Reliever Therapies.

Asthma is one of the most prevalent chronic disorders in children. Anti-inflammatory reliever (AIR) therapy and single maintenance and reliever therapy (SMART) have been adopted into the asthma management of adolescents and adults. However, limited evidence and guidance are currently available for asthma management of younger children with AIR therapy and SMART.

Biomarkers of Immune Dysregulation and What They Tell Us: Gene Sequencing Is Not the Answer to Every Question.

Primary immune regulatory disorders (PIRDs) are inborn errors of immunity, with autoimmune, hyperinflammatory, and lymphoproliferative manifestations as presenting features rather than recurrent infections. Genetic testing remains the primary tool for diagnosing patients with immune defects. Not all suspected PIRDs have a known genetic cause.

Structure of the ATP-driven methyl-coenzyme M reductase activation complex.

Methyl-coenzyme M reductase (MCR) is the enzyme responsible for nearly all biologically generated methane. Its active site comprises coenzyme F, a porphyrin-based cofactor with a central nickel ion that is active exclusively in the Ni(I) state. How methanogenic archaea perform the reductive activation of F represents a major gap in our understanding of one of the most ancient bioenergetic systems in nature.

Free-living predatory cheyletid mites (Acariformes: Cheyletidae) from Cat Tien National Park, Vietnam.

The free-living predatory mites of the family Cheyletidae of the Cat Tien National Park (Vietnam) are reviewed. Females of two monotypic genera, Vietocheyla subiasi gen. and sp.

Long-term assessment of hydropeaking and cumulative impacts on sediment transport, grain size dynamics, channel stability and water resource management.

Hydropeaking refers to rapid and frequent changes in flow discharge and water levels caused by the operation of hydropower dams. This phenomenon is driven by the need to meet fluctuating electricity demands, with water being released or stored to generate power as needed. High energy demand leads to hydropeaking, significantly impacting water resource management in downstream areas.

Prooxidant-based polyolefins exhibiting no evidence of biodegradation under marine environments.

The use of oxo-biodegradable plastics has become increasingly controversial due to insufficient evidence supporting their environmental benefits. In particular, their biodegradability in marine environments remains poorly understood, sparking a global concern that the rapid abiotic fragmentation of these plastics could harm marine ecosystems. Here, we assessed the marine biodegradability of polyethylene and polypropylene films containing a commercial oxo-biodegradable prooxidant and compared them to their untreated counterparts using biochemical oxygen demand tests.

The dHvA effect in Sn-doped PbTe topological crystalline insulator.

We report the synthesis, electrical transport, magnetotransport, and high-field torque magnetometry studies of the topological crystalline insulator SnPb1-xTe (= 0, 0.2, and 0.4).

Examining the Relationship between Aptamer Complexity and Molecular Discrimination of a Low-Epitope Target.

Aptamers are oligonucleotide-based affinity reagents that are increasingly being used in various applications. Systematic evolution of ligands by exponential enrichment (SELEX) has been widely used to isolate aptamers for small-molecule targets, but it remains challenging to generate aptamers with high affinity and specificity for targets with few functional groups. To address this challenge, we have systematically evaluated strategies for optimizing the isolation of aptamers for (+)-methamphetamine, a target for which previously reported aptamers have weak or no binding affinity.

Multiregional transcriptomic profiling provides improved prognostic insight in localized non-small cell lung cancer.

Lung Cancer remains the leading cause of cancer deaths in the USA and worldwide. Non-small cell lung cancer (NSCLC) harbors high transcriptomic intratumor heterogeneity (RNA-ITH) that limits the reproducibility of expression-based prognostic models. In this study, we used multiregional RNA-seq data (880 tumor samples from 350 individuals) from both public (TRACERx) and internal (MDAMPLC) cohorts to investigate the effect of RNA-ITH on prognosis in localized NSCLC at the gene, signature, and tumor microenvironment levels.