Cautionary response strategy and impairment of post-conflict response selection underlie age-related differences in a location-based Stroop task.

Introduction: Research suggests that older adults have deficits in selective attention, a cognitive process often queried through the Stroop task. To tease apart whether this is due to failures to inhibit distracting information or to upregulate attention towards target information, younger and older adults completed a task called the Shape Stroop.

Methods: In this task, participants had to name the color of a shape that was occluded by another shape.

Does stereotype threat influence age-related differences on directed forgetting tasks?

Objectives: The Directed Forgetting paradigm has proven to be a powerful tool to explore motivated forgetting in the lab. Past work has shown that older adults are less able to intentionally suppress information from memory relative to younger adults, which is often attributed to deficits in inhibitory abilities. Instructions in traditional Directed Forgetting tasks contain terms that may elicit stereotype threat in older adults, which may negatively impact memory.

Older adults compensate for switch, but not mixing costs, relative to younger adults on an intrinsically cued task switching experiment.

Introduction: Aging negatively impacts the ability to rapidly and successfully switch between two or more tasks that have different rules or objectives. However, previous work has shown that the context impacts the extent of this age-related impairment: while there is relative age-related invariance when participants must rapidly switch back and forth between two simple tasks (often called "switch costs"), age-related differences emerge when the contexts changes from one in which only one task must be performed to one in which multiple tasks must be performed, but a trial-level switch is not required (e.g.

Principal component analysis suggests multiple dimensions of memory inhibition that are differentially affected by age.

Background: Cognitive inhibition is among the executive functions that decline early in the course of normal aging. Failures to be able to inhibit irrelevant information from memory may represent an essential factor of age-associated memory impairment. While a variety of elaborate behavioral tasks have been developed that presumably all index memory inhibition, the extent to which these different tasks measure the same underlying cognitive construct that declines with age has not been well explored.

Value-directed memory selectivity relies on goal-directed knowledge of value structure prior to encoding in young and older adults.

People are generally able to selectively attend and remember high-value over low-value information. Here, we investigated whether young and older adults would display typical value-based memory selectivity effects for to-be-learned item-value associations when goal-directed information about the meaning of associated values was presented before and after encoding. In two experiments, both young and older adults were presented with one (Experiment 1) or multiple (Experiment 2) lists of words that were arbitrarily paired with different numerical values (e.

Curiosity: The effects of feedback and confidence on the desire to know.

In 10 experiments, we investigated the relations among curiosity and people's confidence in their answers to general information questions after receiving different kinds of feedback: yes/no feedback, true or false informational feedback under uncertainty, or no feedback. The results showed that when people had given a correct answer, yes/no feedback resulted in a near complete loss of curiosity. Upon learning they had made an error via yes/no feedback, curiosity increased, especially for high-confidence errors.

Reduced Hippocampal GABA+ Is Associated With Poorer Episodic Memory in Healthy Older Women: A Pilot Study.

: The current pilot study was designed to examine the association between hippocampal γ-aminobutyric acid (GABA) concentration and episodic memory in older individuals, as well as the impact of two major risk factors for Alzheimer's disease (AD)-female sex and Apolipoprotein ε4 ( ε4) genotype-on this relationship. : Twenty healthy, community-dwelling individuals aged 50-71 (11 women) took part in the study. Episodic memory was evaluated using a Directed Forgetting task, and GABA+ was measured in the right hippocampus using a Mescher-Garwood point-resolved magnetic resonance spectroscopy (MRS) sequence.

Cortical thickness in the right inferior frontal gyrus mediates age-related performance differences on an item-method directed forgetting task.

Evidence suggests that older adults have difficulty relative to younger adults in forgetting irrelevant information. Here we sought to understand the physical basis of this deficit by investigating the relationship between cortical thickness and intentional forgetting, using an item-method directed forgetting task. We tested younger (n = 44) and older (n = 54) adults' memories for words that they were instructed to either remember or to forget, and then extracted cortical thickness values from brain regions previously shown, using functional neuroimaging, to be associated with memory suppression, including the right inferior frontal gyrus, the right postcentral gyrus and the left superior/middle frontal gyrus.

Age, Sex, and Inhibitory Control: Identifying a Specific Impairment in Memorial, But Not Perceptual, Inhibition in Older Women.

Objectives: Declines in the ability to inhibit information, and the consequences to memory of unsuccessful inhibition, have been frequently reported to increase with age. However, few studies have investigated whether sex moderates such effects. Here, we examined whether inhibitory ability may vary as a function of age and sex, and the interaction between these two factors.

Epistemic Curiosity and the Region of Proximal Learning.

We propose a framework for understanding epistemic curiosity as a metacognitive feeling state that is related to the individual's Region of Proximal Learning (RPL), an adaptive mental space where we feel we are on the verge of knowing or understanding. First, we review several historical views, contrasting the RPL perspective with alternative views of curiosity. Second, we detail the processes, conditions, and outcomes within the RPL framework which are proposed to be related to curiosity.

GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer's disease.

In this review, we focus on the potential role of the γ-aminobutyric acidergic (GABAergic) system in age-related episodic memory impairments in humans, with a particular focus on Alzheimer's disease (AD). Well-established animal models have shown that GABA plays a central role in regulating and synchronizing neuronal signaling in the hippocampus, a brain area critical for episodic memory that undergoes early and significant morphologic and functional changes in the course of AD. Neuroimaging research in humans has documented hyperactivity in the hippocampus and losses of resting state functional connectivity in the Default Mode Network, a network that itself prominently includes the hippocampus-presaging episodic memory decline in individuals at-risk for AD.

Corrigendum: Occupational Patterns of Structural Brain Health: Independent Contributions Beyond Education, Gender, Intelligence, and Age.

[This corrects the article DOI: 10.3389/fnhum.2019.

Occupational Patterns of Structural Brain Health: Independent Contributions Beyond Education, Gender, Intelligence, and Age.

Occupational activity represents a large percentage of people's daily activity and thus likely is as impactful for people's general and cognitive health as other lifestyle components such as leisure activity, sleep, diet, and exercise. Different occupations, however, require different skills, abilities, activities, credentials, work styles, etc., constituting a rich multidimensional formative exposure with likely consequences for brain development over the lifespan.

When time's arrow doesn't bend: APOE-ε4 influences episodic memory before old age.

Episodic memory impairment is the hallmark symptom of Alzheimer's Disease (AD). However, episodic memory has also been shown to decline across the lifespan. Here, we investigated whether episodic memory is differentially affected relative to other cognitive abilities before old age, and whether being an Apolipoprotein E (APOE) ε4 carrier -a genetic risk factor for developing AD-exacerbates any such impairments.

Memory and truth: correcting errors with true feedback versus overwriting correct answers with errors.

In five experiments, we examined the conditions under which participants remembered true and false information given as feedback. Participants answered general information questions, expressed their confidence in the correctness of their answers, and were given true or false feedback. In all five experiments, participants hypercorrected when they had made a mistake; that is, they remembered better the correct feedback to errors made with high compared to low confidence.

Perceptual and memory inhibition deficits in clinically healthy older adults are associated with region-specific, doubly dissociable patterns of cortical thinning.

Converging evidence suggests that the cognitive control processes that enable the inhibition of irrelevant information on a perceptual versus a memorial basis are qualitatively different and are underlain by unique neural systems that may be affected differentially in aging. In the current study, we investigated whether individual differences in performance on these 2 types of inhibitory processes were attributable to region-specific patterns of cortical thinning. Clinically healthy older adults completed a pair of behavioral memory and perceptual inhibition tasks and then underwent structural brain imaging.

Functional brain and age-related changes associated with congruency in task switching.

Alternating between completing two simple tasks, as opposed to completing only one task, has been shown to produce costs to performance and changes to neural patterns of activity, effects which are augmented in old age. Cognitive conflict may arise from factors other than switching tasks, however. Sensorimotor congruency (whether stimulus-response mappings are the same or different for the two tasks) has been shown to behaviorally moderate switch costs in older, but not younger adults.

Age-Based Differences in Task Switching Are Moderated by Executive Control Demands.

Objectives: Recent work has identified different aspects of executive function that may underlie cognitive changes associated with age. The current study used a multifactorial design to investigate age sensitivity in the ability to shift between different task sets and the interaction of this ability with several specific aspects of executive control.

Method: A large, well-characterized sample of younger (n = 40) and clinically healthy older (n = 51) adults completed a task switching paradigm in which 3 aspects of executive control were manipulated between subjects: a) sensorimotor demand (the number of distinct stimulus-response options); b) stimulus-level interference (i.

The cognitive control of emotional versus value-based information in younger and older adults.

We investigated age-related changes in the cognitive control of value-based and emotionally valenced information. In 2 experiments, participants completed a selectivity task in which to-be-recalled words differed in value and emotional salience. In Experiment 1, all low-valued words were emotional, and emotional valence (positive/negative) was manipulated between subjects.

Inhibitory Selection Mechanisms in Clinically Healthy Older and Younger Adults.

Objective: Declines in working memory are a ubiquitous finding within the cognitive-aging literature. A unitary inhibitory selection mechanism that serves to guide attention toward task-relevant information and resolve interference from task-irrelevant information has been proposed to underlie such deficits. However, inhibition can occur at multiple time points in the memory-processing stream.

Response-Conflict Moderates the Cognitive Control of Episodic and Contextual Load in Older Adults.

Objectives: Decline in cognitive control is one of the primary cognitive changes in normal aging. Reaching a consensus regarding the nature of these age-related changes, however, is complicated by the complexity of cognitive control as a construct.

Methods: Healthy older and younger adults participated in a multifactorial test of cognitive control.

Neural correlates of impaired cognitive control over working memory in schizophrenia.

Background: One of the most common deficits in patients with schizophrenia (SZ) is in working memory (WM), which has wide-reaching impacts across cognition. However, previous approaches to studying WM in SZ have used tasks that require multiple cognitive-control processes, making it difficult to determine which specific cognitive and neural processes underlie the WM impairment.

Methods: We used functional magnetic resonance imaging to investigate component processes of WM in SZ.

Schizophrenia and emotional rubbernecking.

Orienting toward emotionally salient information can be adaptive, as when danger needs to be avoided. Consistent with this idea, research has shown that emotionally valenced information draws attention more so than does neutral information in healthy individuals. However, at times this tendency is not adaptive, and it may distract the individual from goals.

Metacognition of agency: proximal action and distal outcome.

The cues contributing to people's metacognitions of agency were investigated in two experiments in which people played a computer game that involved trying to "touch", via a mouse moving a cursor, downward scrolling X's (Experiment 1), or trying to "explode" the downward scrolling X's (Experiment 2). Both experiments varied (a) proximal action-related information by either introducing or not introducing Turbulence into the mouse controls and (b) distal outcome-related information such that touched X's "exploded" either 100 or 75 % of the time. Both variables affected people's judgments of agency (JOAs), but the effect was different.

The hypercorrection effect in younger and older adults.

ABSTRACT The hypercorrection effect, which refers to the finding that errors committed with high confidence are more likely to be corrected than are low confidence errors, has been replicated many times, and with both young adults and children. In the present study, we contrasted older with younger adults. Participants answered general-information questions, made confidence ratings about their answers, were given corrective feedback, and then were retested on questions that they had gotten wrong.