Publications by authors named "Taisuke Akimoto"

Background: The management of large thrombosed unruptured vertebral artery (VA) aneurysms is complex and remains a significant clinical challenge.

Observations: A 46-year-old man presented with a headache and was diagnosed with a thrombosed 28-mm aneurysm in the right VA. The initial treatment with a Pipeline flow diverter stent was followed by parent artery occlusion with coils after the aneurysm had enlarged to 40 mm.

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Head trauma accompanied by circulatory failure is a rare but severe condition, and few reports regarding its prognosis or initial treatment strategies have been published. We aimed to evaluate the prognostic factors and treatment strategies for patients with head trauma and vital signs of shock. We included 415 consecutive patients with head trauma (Abbreviated Injury Scale [AIS] score ≥3) who were transported to our institution from January 2017 to December 2023.

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Background: Near-infrared spectroscopy (NIRS) is commonly used to assess brain tissue oxygen levels during surgery, but its applicability in the acute phase of stroke remains uncertain. We examined the usefulness of NIRS for rapid identification of acute large vessel occlusion (LVO) on hospital arrival.

Methods: This pilot, single-center, retrospective study used a prospective database including all patients with suspected stroke.

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Intraventricular haemorrhage (IVH) is a key prognostic factor for subarachnoid haemorrhage (SAH). However, no simple or rapid scoring method for its evaluation exists. We aimed to modify and validate a simple scale for rapid IVH grading.

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Aim: To evaluate the prognostic factors in severe head trauma patients (Glasgow Coma Score (GCS) ≤ 8) with all trauma, including those with trunk injury as well as single severe head trauma (abbreviated injury scale (AIS) ≥ 3).

Methods: We included 152 consecutive patients with head trauma (AIS ≥ 3) and consciousness disorders (GCS ≤ 8) who were transported to our institute from January 2017 to October 2022. Data on the patients' background, vital signs at presentation, multiple trauma (AIS ≥ 3 in two or more locations), surgical intervention, and hematological findings were examined; a retrospective analysis was conducted with the modified Rankin Scale score after 3 months assigned as the primary outcome.

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Background: A vein of Galen aneurysmal malformation (VGAM) is a rare vascular lesion that often requires treatment in the neonatal period or infancy. Neonates and infants have limited catheter access, and the treatment of VGAM often requires multiple procedures. When standard access routes are unavailable, alternative vascular access becomes essential.

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Background: The standard approach for transvenous embolization (TVE) of a cavernous sinus (CS) dural arteriovenous fistula (DAVF) involves the inferior petrosal sinus (IPS). However, the IPS is often obstructed in many cases. In some cases, the IPS is not connected to the internal jugular vein, making access to the CS via the IPS difficult.

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Background and purpose The risk of rupture increases with advancing age. However, the risk-benefit of coil embolization for elderly patients with unruptured aneurysms is controversial. This study aimed to identify factors associated with treatment primary outcomes, including risk factors for complications and aneurysm recurrence requiring re-treatment in the endovascular treatment of unruptured aneurysms in elderly patients.

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Background: Vertebral artery (VA) stenosis can be caused by several factors, including arteriosclerosis, arterial dissection, and mechanical compression. Symptomatic vertebrobasilar insufficiency caused by VA stenosis due to mechanical compression associated with head rotation is well-known as Bow Hunter's syndrome. However, an accurate diagnosis of asymptomatic osteophyte compression-induced nonrotational VA stenosis is difficult.

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Article Synopsis
  • * This study analyzed 28 patients who underwent surgical revascularization and examined various collateral pathways that might affect the occurrence of TNEs.
  • * Findings indicated that the development of specific collateral pathways, particularly posterior pericallosal anastomosis and choroidal anastomosis, significantly predicted the likelihood of TNEs after surgery, suggesting these could serve as reliable preoperative indicators.
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Recent advances in endovascular treatment have improved the safety and efficacy of this procedure, and the number of cases in which preoperative embolization is performed is likely to increase. Preoperative tumor embolization is still a controversial treatment, and as long as it carries a risk of complications, its primary benefit of reducing blood loss during surgery may not be sufficient to justify treatment. We recently reported that preoperative embolization does not significantly increase complications, but may prolong recurrence-free survival.

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Article Synopsis
  • There is growing concern about the health risks of heated tobacco products (HTPs) due to their toxicity, similar to traditional tobacco products.
  • The study used HSC-3 oral cancer cells to analyze the effects of cigarette smoke extract (CSE) from HTPs and traditional cigarettes, focusing on reactive oxygen species (ROS) and calcium signaling.
  • Results showed that both types of CSE caused cell damage, increased ROS and calcium levels, and led to cell death, with the processes being influenced by the protein CaMKK2.
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Objective: Carotid artery stenting embolic protection devices offer various options, among which distal filter protection is the simplest and easiest to handle. However, compared to balloon protection systems, distal filter protection has more embolic complications. Therefore, we explored the risk factors of distal filter protection, intending to achieve a safer carotid artery stenting.

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Application of physical forces, ranging from ultrasound to electric fields, is recommended in various clinical practice guidelines, including those for treating cancers and bone fractures. However, the mechanistic details of such treatments are often inadequately understood, primarily due to the absence of comprehensive study models. In this study, we demonstrate that an alternating magnetic field (AMF) inherently possesses a direct anti-cancer effect by enhancing oxidative phosphorylation (OXPHOS) and thereby inducing metabolic reprogramming.

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This article describes the concept and technical aspects of the occipital transtentorial approach(OTA)for tumor extraction in the pineal region, based on the author's experience and literature review. Awareness of the successful completion of each surgical step is essential. Preoperative preparation and imaging evaluations, with particular attention to the veins and venous sinuses, are especially important.

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Objectives: The superiority and usefulness of liquid material over particles for embolization have been a topic of debate due to differences in materials and techniques. This study aimed to identify the complications and outcomes associated with both embolization materials.

Methods: This retrospective multicenter cohort study included 93 patients from an endovascular treatment registry, treated from January 1, 2018 to May 31, 2022.

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Article Synopsis
  • * A study of 132 combined treatments found that 15.1% of patients experienced a decline in neurological function three months after surgery, with embolization complications occurring in 6.3% of cases and surgery-related complications in 15.2%.
  • * Key risk factors for worsening outcomes included the migration of embolic material and higher blood loss during surgery, particularly from specific arteries, highlighting the need for careful planning and understanding of vascular anatomy.
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Background: Takotsubo cardiomyopathy (TC) is a well-known complication of subarachnoid haemorrhage (SAH), often accompanied by neurogenic myocardial dysfunction. Although TC has been reported to be associated with higher morbidity and mortality among patients with aneurysmal SAH (aSAH), some patients have been reported to recover, the profiles and follow-up outcomes of these survivors remain unclear.

Materials And Methods: To characterize the profiles of patients with aSAH complicated by TC who experienced favourable outcomes using long-term follow-up data, a consecutive series of patients with aSAH were enrolled and TC diagnosis was based on the revised version of the Mayo Clinic criteria.

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Introduction This study aimed to determine the optimal timing for surgical intervention and the prognostic factors of cerebrospinal fluid (CSF) leakage. Methods We identified 25 patients with probable CSF leaks from 472 consecutive patients with head trauma. In addition to baseline characteristics and findings on admission, injury severity score (ISS), abbreviated injury score (AIS), and other factors related to CSF leakage were considered.

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Background: Intraosseous clival arteriovenous fistulas (AVFs), in which the shunt drains extracranially from the posterior and anterior condylar veins rather than from the cavernous sinus (CS), are rare. Targeting embolization of an intraosseous clival AVF is challenging because of its complex venous and skull base anatomy; therefore, a therapeutic strategy based on detailed preoperative radiological findings is required to achieve a favorable outcome. Here, the authors report the successful targeted embolization of an intraosseous clival AVF using an ingenious access route.

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Article Synopsis
  • The study investigated the impact of treatment timing (on-duty vs. off-duty hours) on outcomes for patients undergoing endovascular treatment for acute ischemic stroke.
  • It analyzed data from 1,571 patients in a multicenter registry, focusing on the modified Rankin Scale (mRS) at 90 days post-stroke as the primary outcome measure.
  • Results indicated no significant difference in mRS scores between on-duty and off-duty patients, but off-duty patients experienced longer door-to-puncture times, leading to poorer outcomes when that time exceeded 60 minutes, influenced by factors like low NIHSS scores and diabetes.
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Article Synopsis
  • - The study highlights the urgent need for biologically compatible vascular grafts and explores a new method called hydrostatic pressurization under hypoxia (HP/HYP) to create multi-layered vascular walls using human vascular smooth muscle cells.
  • - The HP/HYP method enhances essential cell functions like attachment and collagen production, resulting in the successful creation of robust 10-layered vascular grafts that are strong enough for use.
  • - When implanted in rats, these grafts showed promising results, becoming lined with endothelial cells within a week and remaining functional for five months, which suggests that this technique could advance vascular grafts for treating cardiovascular diseases.
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Objectives: Carotid artery stenting is sometimes adapted for some at-risk cases; however, appropriate treatment timing with stroke onset is controversial. This study aims to identify factors that have an impact on complications and outcomes, especially in patients at high risk.

Materials And Methods: We examined the characteristics of 152 consecutive patients treated by carotid artery stenting between January 2018 and March 2022 and retrospectively analyzed the risk factors for complications and poor outcomes (modified-Rankin-Scale deterioration), such as patient background, carotid artery stenting risks (access route tortuosity, severe calcification, vulnerable plaque, estimated glomerular filtration rate <30 mL/min/1.

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Objective: To identify factors associated with the outcome and prognosis of coil embolization for poor-grade aneurysmal subarachnoid hemorrhage (aSAH).

Methods: We retrospectively reviewed 118 patients with World Federation of Neurosurgical Societies (WFNS) grade IV or V subarachnoid hemorrhage at our institute between January 2010 and December 2020. Outcomes were assessed using modified Rankin Scale (mRS) scores at discharge and at six months after aSAH onset.

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Objective: To report a case of symptomatic large cerebral aneurysm of the internal carotid artery (ICA), associated with a primitive trigeminal artery variant (PTAv), which was treated with a balloon occlusion test (BOT) to evaluate ischemic tolerance.

Case Presentation: A 79-year-old woman was diagnosed with a symptomatic large cerebral aneurysm of the ICA bifurcating the PTAv due to diplopia. After confirming the ischemic tolerance of the perfusion area and PTAv by BOT, we performed ICA parent artery occlusion with selective embolization of the PTAv.

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