Preliminary outcomes of healthy sleep practices and mind-body integrative health intervention among urban youth: Feasibility, acceptability, and initial impact.

Objective: To evaluate feasibility, acceptability, and initial effects of Sleeping Healthy, Living Healthy (SHLH), an integrated behavioral sleep-mind-body integrative health (MBIH) intervention to improve sleep health, among urban adolescents.

Methods: Sixty-one adolescents (66% female; 84% Hispanic/Latino; 25% Black or African American) who slept less than 8 h/weeknight from two NYC high school campuses were randomized to SHLH (n = 30) or an attention-control group (n = 31). Outcomes assessed at baseline, immediately postintervention, and 10 weeks postintervention included sleep quality (Pittsburgh Sleep Quality Index (PSQI)); PROMIS sleep-related impairment; stress and anxiety; and perceived stress (Perceived Stress Scale).

Waning light, waxing pain: The lunar cycle's association with migraine headache occurrence.

Objective: To examine circalunar rhythms in migraine headache occurrence in a prospective cohort of 98 adults with episodic migraine.

Background: Migraine is a prevalent neurological disorder characterized by paroxysmal attacks. While time-of-day and seasonal rhythmicity in migraine occurrence have been described, little is known about circalunar patterns.

Lifetime history of hypertensive disorders of pregnancy is associated with shorter sleep duration and more sleep disturbance in midlife: results from the Project Viva women's health cohort.

Background: Hypertensive disorders of pregnancy (HDP) are associated with worse prenatal and perinatal sleep health and higher cardiovascular disease risk beyond the peripartum period. The relationship of HDP with sleep health in midlife, when sleep problems are common, remains unclear.

Methods: We studied women enrolled in Project Viva during early pregnancy (1999-2002) with sleep outcomes assessed in midlife (2017-2024).

Actigraphy-derived sleep fragmentation index: convergent validity and associations with clinical outcomes.

Study Objectives: Wake after sleep onset and sleep efficiency derived from actigraphy are common assessments of sleep fragmentation (or continuity). The sleep fragmentation index (SFI), measuring the frequency of sleep-wake transitions, is less understood. This study examined (1) the convergent validity between SFI and other sleep metrics obtained by actigraphy and polysomnography; and (2) associations of SFI with sleep symptoms, obstructive sleep apnea, periodic limb movement index, and cognition (Digit Symbol Coding test).

Atomoxetine plus oxybutynin for symptomatic snoring and airflow limitation in individuals without moderate-to-severe obstructive sleep apnea.

Study Objectives: Sleep-disordered breathing is incompletely characterized by the apnea-hypopnea index. Although typically viewed as milder disease, snoring and flow limitation can yield major deficits in sleep health for both patients and their bed partners. Here we tested whether a combined noradrenergic and antimuscarinic intervention to activate pharyngeal muscles yields improved snoring loudness and flow limitation severity, plus self-reported outcomes, by snorers and their bed partners.

Mapping the relationships between structural brain MRI characteristics and sleep electroencephalography patterns: the Multi-Ethnic Study of atherosclerosis.

While brain morphology is well-established as a key factor influencing overall brain function, little is known about how brain structural properties are associated with oscillatory activity, particularly during sleep. In this study, we analyzed whole-night sleep electroencephalography (EEG) and brain structural MRI data from a subset of 621 individuals in the Multi-Ethnic Study of Atherosclerosis to explore the relationship between brain structure and sleep EEG properties. We found that larger total white matter (WM) volume was associated with higher absolute broad-band power, regardless of sleep stage, likely reflecting WM contribution to enhanced synchronization across cortical regions and reduced activation attenuation via long-range myelinated fibers.

Leveraging digital therapeutics to improve physician sleep: a pilot implementation study.

Unlabelled: Given the high prevalence of physician burnout, strategies are needed to improve physician mental health and well-being. As sleep disturbance predicts burnout, there is a need to evaluate evidence-based, potentially scalable treatments that target physician sleep and sleep-related health. This pilot implementation study enrolled physicians and gave them access to the Sleep Healthy Using the Internet, a 6-session self-guided cognitive behavioral therapy for insomnia treatment program.

Migraine and sleep apnea, insomnia, and sleep patterns in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Objective: To quantify the prevalence of migraine and examine its association with sleep disorders, patterns, and symptoms in adults in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL). We hypothesized that migraine would be associated with insomnia but not sleep apnea.

Background: Sparse research has examined migraine prevalence and sleep comorbidities in underrepresented racial and ethnic groups in the United States.

Spontaneous Pain and Pain Sensitivity in Response to Prolonged Experimental Sleep Disturbances-Potential Sex Differences.

Introduction: Insomnia is a highly prevalent condition that predisposes individuals to many chronic pain disorders, with most of them showing pronounced sexual dimorphism. We investigated whether experimental insomnia-like sleep disturbances (ESD) affect spontaneous pain and pain sensitivity, and whether sex modulates pain responses.

Methods: Twenty-four healthy participants (50% females, age 28.

Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus: The Hispanic Community Health Study/Study of Latinos.

Objective: We sought to evaluate whether obstructive sleep apnea (OSA), and other sleep disorders, increase genetic risk of developing diabetes mellitus (DM).

Research Design And Methods: Using GWAS summary statistics from the DIAGRAM consortium and Million Veteran Program, we developed multi-ancestry Type 2 Diabetes (T2D) polygenic risk scores (T2D-PRSs) useful in admixed Hispanic/Latino individuals. We estimated the association of the T2D-PRS with cross-sectional and incident DM in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Effects of low-dose acetylsalicylic acid on the inflammatory response to experimental sleep restriction in healthy humans.

Background: Sleep deficiencies, such as manifested in short sleep duration or insomnia symptoms, are known to increase the risk for multiple disease conditions involving immunopathology. Inflammation is hypothesized to be a mechanism through which deficient sleep acts as a risk factor for these conditions. Thus, one potential way to mitigate negative health consequences associated with deficient sleep is to target inflammation.

Habitual caffeinated beverage consumption and headaches among adults with episodic migraine: A prospective cohort study.

Objective: To examine the relationship between habitual caffeinated beverage consumption and headache frequency, duration, and intensity in a prospective cohort of adults with episodic migraine.

Background: Caffeine is a commonly ascribed headache trigger in adults with migraine and clinicians may counsel patients to avoid caffeinated beverages; however, few studies have examined this association.

Methods: From March 2016 to August 2017, 101 adults with physician-confirmed episodic migraine completed baseline questionnaires, including information about caffeinated beverage consumption.

Combination pharmacological therapy targeting multiple mechanisms of sleep apnoea: a randomised controlled cross-over trial.

Rationale: Acetazolamide and atomoxetine-plus-oxybutynin ('AtoOxy') can improve obstructive sleep apnoea (OSA) by stabilising ventilatory control and improving dilator muscle responsiveness respectively. Given the different pathophysiological mechanisms targeted by each intervention, we tested whether AtoOxy-plus-acetazolamide would be more efficacious than AtoOxy alone.

Methods: In a multicentre randomised crossover trial, 19 patients with moderate-to-severe OSA received AtoOxy (80/5 mg), acetazolamide (500 mg), combined AtoOxy-plus-acetazolamide or placebo at bedtime for three nights (half doses on first night) with a 4-day washout between conditions.

Associations of adverse childhood and lifetime experiences with sleep quality and duration among women in midlife.

Objectives: Many women experience sleep problems during midlife. Associations of adverse lifetime experiences-more common among women-with sleep outcomes are understudied.

Methods: We studied 476 women enrolled in Project Viva 1999-2002.

Do Insomnia Treatments Improve Daytime Function?

A scientific advisory panel of seven U.S. and Canadian sleep experts performed a clinical appraisal by comparing general medical opinion, assessed via a survey of practicing clinicians, regarding insomnia treatment, with the available scientific evidence.

Quantifying the impact of the Philips recall on patients with sleep apnea and clinicians.

Study Objectives: Philips Respironics issued a voluntary recall of positive airway pressure devices used to treat obstructive sleep apnea in June 2021. We surveyed sleep medicine clinicians from the American Academy of Sleep Medicine membership to assess the impact of the recall on clinicians and patients.

Methods: One hundred thirty-six clinicians participated between June 2022 and November 2022.

Should Trazodone Be First-Line Therapy for Insomnia? A Clinical Suitability Appraisal.

Trazodone is one of the most commonly used prescription medications for insomnia; however, some recent clinical guidelines do not recommend its use for treating insomnia. This clinical appraisal critically reviews the scientific literature on trazodone as a first-line treatment for insomnia, with the focus statement "." In addition, field surveys were sent to practicing physicians, psychiatrists, and sleep specialists to assess general support for this statement.

Wake Up America: National Survey of Patients' and Physicians' Views and Attitudes on Insomnia Care.

While both patients and physicians consider sleep to be important, sleep health may not receive appropriate consideration during patient visits with health care professionals (HCPs). We completed the first large-scale survey of people with trouble sleeping (PWTS) and physicians who treat insomnia to understand their perspectives and potential discrepancies between them. The Harris Poll conducted online surveys of adult PWTS and HCPs (primary care physicians [PCPs] and psychiatrists) in the United States from September to October 2021.

Alterations of pain pathways by experimental sleep disturbances in humans: central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways.

Study Objectives: There is strong evidence that sleep disturbances are an independent risk factor for the development of chronic pain conditions. The mechanisms underlying this association, however, are still not well understood. We examined the effect of experimental sleep disturbances (ESDs) on three pathways involved in pain initiation/resolution: (1) the central pain-inhibitory pathway, (2) the cyclooxygenase (COX) pathway, and (3) the endocannabinoid (eCB) pathway.

Long-Term Use of Insomnia Medications: An Appraisal of the Current Clinical and Scientific Evidence.

While evidence supports the benefits of medications for the treatment of chronic insomnia, there is ongoing debate regarding their appropriate duration of use. A panel of sleep experts conducted a clinical appraisal regarding the use of insomnia medications, as it relates to the evidence supporting the focus statement, "No insomnia medication should be used on a daily basis for durations longer than 3 weeks at a time". The panelists' assessment was also compared to findings from a national survey of practicing physicians, psychiatrists, and sleep specialists.

Examining understandability, information quality, and presence of misinformation in popular YouTube videos on sleep compared to expert-led videos.

Unlabelled: The Internet is a common source of sleep information but may be subject to commercial bias and misinformation. We compared the understandability, information quality, and presence of misinformation of popular YouTube videos on sleep to videos with credible experts. We identified the most popular YouTube videos on sleep/insomnia and 5 videos from experts.