Elevated red blood cell-derived extracellular vesicles under hyperglycemic conditions are associated with CD47 expression and production of intracellular reactive oxygen species.

Diabetes mellitus (DM), particularly type 2 DM, is characterized by chronic hyperglycemia, which has notable effects on red blood cells (RBCs), including alterations in membrane integrity, morphology and function. The present study aimed to assess the effect of oxidative stress under hyperglycemic conditions on RBC-derived extracellular vesicle (REV) production using an model. RBCs from healthy participants were cultured in several glucose concentrations (5, 45 and 100 mM) to mimic euglycemic, intermediate and severe hyperglycemic conditions.

Alterations in von Willebrand Factor Levels in Patients with Malaria: A Systematic Review and Meta-Analysis of Disease Severity.

: Elevated von Willebrand factor (vWF) levels have been reported in malaria, but their relationship with disease severity remains unclear. This study aimed to compare vWF levels between -infected and uninfected individuals and assess changes in severe infections. : The systematic review was registered in PROSPERO (CRD42024558479).

Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis.

D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. The systematic review was registered in PROSPERO with registration number CRD42024528245.

Extracellular vesicles released by ALL patients contain HNE-adducted proteins: Implications of collateral damage.

Off-target neuronal injury is a serious side-effect observed in cancer survivors. It has previously been shown that pediatric acute lymphoblastic leukemia (ALL) survivors have a decline in neurocognition compared to healthy age-matched counterparts. Elevated oxidative stress has been documented to be a mediator in off-target tissue damage in cancer survivors.

The Roles of Mitochondria in Human Being's Life and Aging.

The universe began 13.8 billion years ago, and Earth was born 4.6 billion years ago.

Alteration of prothrombin time in Plasmodium falciparum and Plasmodium vivax infections with different levels of severity: a systematic review and meta-analysis.

Malaria infection leads to hematological abnormalities, including deranged prothrombin time (PT). Given the inconsistent findings regarding PT in malaria across different severities and between Plasmodium falciparum and P. vivax, this study aimed to synthesize available evidence on PT variations in clinical malaria.

Mitochondrial oxidative stress, mitochondrial ROS storms in long COVID pathogenesis.

Significance: This review discusses the coronavirus disease 2019 (COVID-19) pathophysiology in the context of diabetes and intracellular reactions by COVID-19, including mitochondrial oxidative stress storms, mitochondrial ROS storms, and long COVID.

Recent Advances: The long COVID is suffered in ~10% of the COVID-19 patients. Even the virus does not exist, the patients suffer the long COVID for even over a year, This disease could be a mitochondria dysregulation disease.

A Systematic Review and Meta-Analysis of the Proportion Estimates of Disseminated Intravascular Coagulation (DIC) in Malaria.

Disseminated intravascular coagulation (DIC) is a potentially life-threatening condition that causes systemic coagulation to be turned on and coagulation factors to be used up. However, the evidence for DIC in malaria patients is still not clear, and small case series and retrospective studies have shown varying results. This meta-analysis was intended for the evaluation of the evidence of DIC among malaria patients using a meta-analysis approach.

Evaluation of Susceptibility of the Human Pathogen to the Antibiotic Capreomycin.

infection causes gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma, and gastric cancer and can also promote thrombosis. It is estimated that approximately 4.5 billion individuals are infected, thus rendering the most prevalent microbial pathogen.

Effects of Leaf Extract on the Alteration of Blood Coagulation Parameters and Platelet Count in -Infected Mice.

Malaria remains highly prevalent and one of the major causes of morbidity and mortality in tropical and subtropical regions. Alteration of blood coagulation and platelets has played an important role and attributed to increased morbidity in malaria. Hence, this study was performed to investigate the efficacy of leaf extract on -induced alteration of blood coagulation parameters and platelet numbers in mice.

Extracellular vesicles released after cranial radiation: An insight into an early mechanism of brain injury.

Cranial radiation is important for treating both primary brain tumors and brain metastases. A potential delayed side effect of cranial radiation is neurocognitive function decline. Early detection of CNS injury might prevent further neuronal damage.

Modulation of platelet functions by Roxb. leave extracts.

Platelets form a plug to prevent blood loss and contribute to wound healing. Kradonbok, Roxb., is a Thai plant with medicinal properties.

The Potential Role of Leaf Extract Treatment in Hematological Parameters in Mice Infected with .

Malaria remains a significant cause of death in tropical and subtropical regions by serious complications with hematological abnormalities consistent with high parasitemia. Hence, this study aimed to determine the efficacy of the leaf extract (GIE) on hematological alteration in infection in mice. Groups of ICR mice were infected intraperitoneally with parasitized red blood cells of ANKA (PbANKA).

Extracellular vesicle-mediated macrophage activation: An insight into the mechanism of thioredoxin-mediated immune activation.

Extracellular vesicles (EVs) generated from redox active anticancer drugs are released into the extracellular environment. These EVs contain oxidized molecules and trigger inflammatory responses by macrophages. Using a mouse model of doxorubicin (DOX)-induced tissue injury, we previously found that the major sources of circulating EVs are from heart and liver, organs that are differentially affected by DOX.

A survey of jellyfish sting knowledge among Thai divers in Thailand.

Background: In tropical regions, jellyfish envenomation is a persistent hazard for people who spend time in the sea. Jellyfish stings can be dangerous, and among the people who face the greatest risk are scuba divers. This study therefore sought to determine the level of knowledge divers in Thailand have about the threat of jellyfish envenomation.

Clinical severity of β-thalassaemia/Hb E disease is associated with differential activities of the calpain-calpastatin proteolytic system.

Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this study was to correlate the activity of calpain and its inhibitor, calpastatin, with different degrees of disease severity in β-thalassaemia. CD34(+) cells were enriched from peripheral blood of healthy individuals (control group) and patients with mild and severe clinical presentations of β(0)-thalassaemia/Hb E disease.