Prevalence and subtype distribution of Blastocystis infections among community participants in Thailand: a systematic review and meta-analysis.

A comprehensive understanding of the prevalence and subtype distribution of Blastocystis infections among community participants in Thailand is essential to inform targeted public health interventions. This systematic review and meta-analysis aimed to estimate the overall prevalence of Blastocystis infections and to determine the distribution of subtypes among community participants in Thailand. Relevant studies on Blastocystis infections in community participants in Thailand were searched in PubMed, Embase, Scopus, Ovid, ProQuest, and the Thai-Journal Citation Index.

Penicillium-Derived Inhibitors of Lactate Dehydrogenase (PfLDH): A Computational Approach for Novel Antimalarial Therapy Development.

Malaria remains a major global health challenge, necessitating the discovery of novel therapeutic agents. This study investigates secondary metabolites from spp. as potential inhibitors of lactate dehydrogenase (PfLDH), a critical enzyme in the parasite's glycolytic pathway.

Prevalence Estimates and Distribution of Entamoeba histolytica and Entamoeba dispar Infections in Several Regions of Thailand: A Systematic Review and Meta-Analysis.

Entamoeba histolytica (E. histolytica) causes amebiasis, which is a major health concern in tropical regions, including Thailand. This systematic review and meta-analysis aimed to assess the prevalence, distribution, and epidemiological trends of E.

First report of biological contaminants in household water in the Philippines and long-term viability of Acanthamoeba species in one-year-old household water sediment.

This study aimed to detect biological contaminants, specifically Cryptosporidium, Cyclospora, Giardia, and FLAs, in Metro Manila, Philippines' household water samples. Eighty household water samples comprising 40 unfiltered water/water filter scrapings (F0) and 40 filtered water samples (F1) were filtered through a 1.2 μm-pore glass microfiber filter.

Evidence of pathogens associated with travelers' diarrhea in Thailand: a systematic review.

Background: Thailand, a major tourist destination, exhibits variations in sanitation and food safety practices that can lead to cases of travelers' diarrhea (TD) caused by a plethora of pathogens. This systematic review synthesizes data on the pathogens associated with TD in Thailand, providing valuable insights into pathogen diversity and distribution, traveler profiles, and geographical regions of concern.

Methods: This systematic review followed the PRISMA guidelines and was registered in PROSPERO (CRD42022346014).

Alterations in von Willebrand Factor Levels in Patients with Malaria: A Systematic Review and Meta-Analysis of Disease Severity.

: Elevated von Willebrand factor (vWF) levels have been reported in malaria, but their relationship with disease severity remains unclear. This study aimed to compare vWF levels between -infected and uninfected individuals and assess changes in severe infections. : The systematic review was registered in PROSPERO (CRD42024558479).

A Systematic Review and Meta-Analysis of MIP-1α and MIP-1β Chemokines in Malaria in Relation to Disease Severity.

: Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β act as signaling molecules that recruit immune cells to sites of infection and inflammation. This study aimed to synthesize evidence on blood levels of MIP-1α and MIP-1β in -infected individuals and to determine whether these levels differ between severe and uncomplicated malaria cases. : The study protocol was registered in PROSPERO (CRD42024595818).

A systematic review and meta-analysis of the prevalence and risk of syphilis among blood donors in Thailand.

Despite rising rates of sexually transmitted infections (STIs) in Thailand, including syphilis, data on its prevalence and associated risk factors among blood donors remain scarce. This systematic review and meta-analysis aimed to estimate the prevalence of syphilis and identify the key risk factors among blood donors in Thailand to inform targeted interventions for enhanced blood safety.The study protocol was registered in PROSPERO (CRD42024560215) and conducted following PRISMA guidelines.

Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis.

D-dimer, a byproduct of cross-linked fibrin degradation, arises during the fibrinolysis process, breaking down blood clots in circulation. This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity. The systematic review was registered in PROSPERO with registration number CRD42024528245.

A systematic review of circulating IP-10/CXCL10 in patients with Plasmodium infections in relation to disease severity.

Interferon γ-induced protein 10 kDa (IP-10) or C-X-C motif chemokine 10 (CXCL10) is produced and secreted from specific leukocytes such as neutrophils, eosinophils, and monocytes, which play key roles in the immune response to Plasmodium infections. This systematic review aimed to collate and critically appraise the current evidence on IP-10 levels in malaria patients. It provided insights into its role in malaria pathogenesis and potential as a biomarker for Plasmodium infections and disease severity.

Alteration of ceruloplasmin in patients with malaria: a systematic review and meta-analysis of observational studies.

Background: The evidences of oxidative stress-related Plasmodium infection may alter the ceruloplasmin levels were inconsistent. This systematic review and meta-analysis aimed to collate and synthesize literatures on malaria and ceruloplasmin concentrations.

Methods: The systematic review has been registered with PROSPERO (CRD42023454859).

A systematic review and meta-analysis of blood level of MCP-1/CCL-2 in severe and uncomplicated malaria.

Monocyte chemoattractant protein-1 (MCP-1) or C-C Motif Chemokine Ligand 2 (CCL-2) is a key chemokine implicated in the inflammatory response to malaria. The objective of the study was to synthesize the evidence on variations in MCP-1/CCL-2 levels in relation to Plasmodium spp. infections and the severity of malaria.

Association between RANTES/CCL5 levels with Plasmodium infections and malaria severity: a systematic review.

Background: Malaria continues to be a significant global health concern, and developing effective therapeutic strategies requires an understanding of the immune response to the disease. This systematic review synthesized the current body of research on the role of regulated on activation, normal T cell expressed and secreted (RANTES)-in the pathogenesis and disease severity of malaria.

Methods: A systematic review protocol was registered with PROSPERO under the registration number CRD42024535822.

Estimating the impact of imported malaria on local transmission in a near elimination setting: a case study from Bhutan.

Background: Bhutan has achieved a substantial reduction in both malaria morbidity and mortality over the last two decades and is aiming for malaria elimination certification in 2025. However, a significant percentage of malaria cases in Bhutan are imported (acquired in another country). The aim of the study was to understand how importation drives local malaria transmission in Bhutan.

Health-related issues of people experiencing homelessness in Thailand: a scoping review.

Introduction: Homelessness is a significant global challenge affecting people worldwide. In Thailand, the health-related issues of people experiencing homelessness have not been a major research focus. This scoping review aims to explore the scope of research on health-related issues among people experiencing homelessness in Thailand.

A systematic review and meta-analysis of cortisol levels in Plasmodium infections.

Malaria has complex interactions with host physiology, including alterations in cortisol levels. Cortisol, a key hormone in the stress response, is known to be dysregulated in various infectious diseases. This systematic review and meta-analysis aimed to elucidate the relationship between Plasmodium infection and cortisol levels, shedding light on the intricate interplay between the parasite and the host's endocrine system.

Total antioxidant status levels in malaria: a systematic review and meta-analysis.

Background: Malaria, a severe health threat, significantly affects total antioxidant status (TAS) levels, leading to considerable oxidative stress. This systematic review and meta-analysis aimed to delineate differences in TAS levels between malaria patients and healthy controls, and assess correlations between disease severity and parasite density.

Methods: The systematic review was registered with the International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42023448761.

Prevalence estimates of Opisthorchis viverrini and Clonorchis sinensis infection in the Greater Mekong subregion: a systematic review and meta-analysis.

Background: Opisthorchiasis and clonorchiasis, caused by Opisthorchis viverrini and Clonorchis sinensis, respectively, are significant yet neglected foodborne trematodiases in the Great Mekong Subregion (GMS). Despite the reporting of the prevalence of these human liver flukes in the region over the past decades, there has been a lack of a comprehensive and systematic consolidation of this data. Therefore, we aimed to conduct a thorough systematic review and meta-analysis to synthesize and analyze time-trend prevalence estimates of both O.

Albumin levels in malaria patients: a systematic review and meta-analysis of their association with disease severity.

Albumin, a key protein in human blood plasma, has been linked to various health conditions. However, its association with malaria, particularly in assessing disease severity, remains inadequately understood. This comprehensive systematic review and meta-analysis aimed to elucidate the relationship between albumin levels and malaria severity.

Alteration of prothrombin time in Plasmodium falciparum and Plasmodium vivax infections with different levels of severity: a systematic review and meta-analysis.

Malaria infection leads to hematological abnormalities, including deranged prothrombin time (PT). Given the inconsistent findings regarding PT in malaria across different severities and between Plasmodium falciparum and P. vivax, this study aimed to synthesize available evidence on PT variations in clinical malaria.

Evaluation of Immunodiagnostic Performances of Peroxiredoxin 2 (NcPrx2), Microneme 4 (NcMIC4), and Surface Antigen 1 (NcSAG1) Recombinant Proteins for Bovine Neosporosis.

Bovine neosporosis is among the main causes of abortion in cattle worldwide, causing serious economic losses in the beef and dairy industries. A highly sensitive and specific diagnostic method for the assessment of the epidemiology of the disease, as well as it surveillance and management, is imperative, due to the absence of an effective treatment or vaccine against neosporosis. In the present study, the immunodiagnostic performance of peroxiredoxin 2 (NcPrx2), microneme 4 (NcMIC4), and surface antigen 1 (NcSAG1) to detect IgG antibodies against in cattle were evaluated and compared with that of the indirect fluorescent antibody test (IFAT).

Methemoglobin levels in malaria: a systematic review and meta-analysis of its association with Plasmodium falciparum and Plasmodium vivax infections and disease severity.

Reports indicate that Plasmodium infections influence methemoglobin levels. However, findings have been inconclusive or have varied across different geographic and demographic contexts. This systematic review and meta-analysis aimed to consolidate existing data regarding the association between Plasmodium infections and alterations in methemoglobin levels related to the severity of the infection.

Mitochondria Play Essential Roles in Intracellular Protection against Oxidative Stress-Which Molecules among the ROS Generated in the Mitochondria Can Escape the Mitochondria and Contribute to Signal Activation in Cytosol?

Questions about which reactive oxygen species (ROS) or reactive nitrogen species (RNS) can escape from the mitochondria and activate signals must be addressed. In this study, two parameters, the calculated dipole moment (debye, D) and permeability coefficient (Pm) (cm s), are listed for hydrogen peroxide (HO), hydroxyl radical (•OH), superoxide (O), hydroperoxyl radical (HO•), nitric oxide (•NO), nitrogen dioxide (•NO), peroxynitrite (ONOO), and peroxynitrous acid (ONOOH) in comparison to those for water (HO). O is generated from the mitochondrial electron transport chain (ETC), and several other ROS and RNS can be generated subsequently.

A systematic review and meta-analysis of the relationship between magnesium levels and malaria severity.

Magnesium is associated with Plasmodium infections and malaria severity. This systematic review and meta-analysis was conducted to synthesize the link between Plasmodium infections and magnesium levels for improved clinical guidance and therapeutic interventions in malaria-affected regions. A systematic literature search was conducted across multiple databases, including ProQuest, Scopus, Embase, Ovid, MEDLINE, PubMed, and Google Scholar.