Clinical Implications and Patient Outcomes Associated with otic Resistance in Saudi Arabian Intensive Care Unit Facilities: A Perspective.

Introduction: Antimicrobial Resistance (AMR) poses a significant global health threat, leading to increased morbidity, mortality, and healthcare costs. Intensive Care Units (ICUs) are particularly susceptible to AMR due to frequent invasive procedures, extended hospital stays, and the selective pressure exerted by broad-spectrum antibiotics. This review aims to shed light on the current landscape of antibiotic resistance within ICUs of Saudi hospitals.

Tracing global inequities in radiology research: a multi-level analysis of research output.

Background: Authorship disparities in medical research are evident, particularly between high-income countries (HICs) and low- and middle-income countries (LICs/LMICs). These disparities have been analyzed in recent publications in Pediatric Radiology journal, noting that between 2019 and 2022, no manuscripts from LICs and only 13 manuscripts from LMICs were published. To our knowledge, an extensive review of publication trends in Pediatric Radiology journal and in radiology word containing journals, with regard to LICs/LMICs disparities, is currently lacking.

Exploring vegetation health in Southern Thailand under climate stress from temperature and water impacts between 2000 and 2023.

This study provides a detailed spatiotemporal analysis of vegetation health in Southern Thailand from 2000 to 2023, focusing on the impacts of temperature and water stress on vegetation degradation. Using high-resolution Landsat-derived kernel Normalized Difference Vegetation Index (kNDVI) and Land Surface Temperature (LST), alongside precipitation (PPT), soil moisture (SM), vapor pressure deficit (VPD), and solar radiation (SR), several key indices were derived such as Vegetation Condition Index (VCI), Temperature Condition Index (TCI), and Vegetation Health Index (VHI). The study offers a robust framework to monitor vegetation health under climate stress by integrating satellite-based indices with detailed climate datasets.

The Journal of Robotic Surgery at a glance: productivity, impact, and thematic evolution.

This study presents a comprehensive bibliometric evaluation of the Journal of Robotic Surgery (JORS), analyzing its scientific output, thematic evolution, collaboration patterns, and citation performance to support its continued strategic growth in the field of surgical innovation. A total of 2190 articles and reviews published in JORS were retrieved from Scopus (as of July 2025), with 1846 documents receiving 19,031 citations and yielding an h-index of 45. Author productivity analysis revealed ten key contributors with at least 15 publications, led by Patel, V.

Nutritional and Therapeutic Potential of Pods: A Comprehensive Study on Mineral Composition, Immunomodulation, Antidiabetic Benefits, and Safety of Amaltas Tea in Southeast Punjab, Pakistan.

a plant belonging to the Leguminosae family, grows in various regions, including South Africa, Asia, China, America, Canada, Bangladesh, Afghanistan, Pakistan, Brazil, and West India. Southeast Punjab, Pakistan, has long utilized tea, which is becoming more popular due to its high mineral content, phytochemical compounds, and possible medical properties. This study investigates how to improve immunity, control diabetes, and ensure that it is safe to use.

Eugenol: An Insight Into the Anticancer Perspective and Pharmacological Aspects.

The aura of the 21st century has been transformed due to a revolutionized health care system and modern industrial applications. However, human health and well-being are still a global challenge, affected by various metabolic and pathological morbidities, causing millions of mortalities. Cancer is one of the leading causes of fatalities globally, occurring due to pathogens, dietary factors, environmental toxins, occupational chemical exposure, and radiation.

Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials.

Human physiology is a complex process encompassing various biochemical mechanisms, regulated by hundreds of chemical mediators, thus making it more complicated to understand. Balance between these mediators is mandatory to continue the helm of life; however, an imbalance can disrupt normal physiological functions and lead to chronic health conditions. Cancer is one such chronic state that occurs due to an imbalance or overproduction of reactive oxygen and nitrogen species (RONS), which are highly unstable and damage other chemical constituents in the body.

Multi-dynamic deep image prior for cardiac MRI.

Purpose: Cardiovascular magnetic resonance imaging is a powerful diagnostic tool for assessing cardiac structure and function. However, traditional breath-held imaging protocols pose challenges for patients with arrhythmias or limited breath-holding capacity. This work aims to overcome these limitations by developing a reconstruction framework that enables high-quality imaging in free-breathing conditions for various dynamic cardiac MRI protocols.

An Updated Review of the Anticancer Mechanisms and Therapeutic Potential of Naringenin.

The revolution in the 21st century has witnessed the development of the industrial and healthcare systems. Human health and well-being are still global challenges despite this modernization and advancement. Cancer is extensively affecting people, demanding special attention and an effective dietary approach.

A Comprehensive Review on the Molecular Mechanism of Lycopene in Cancer Therapy.

The continuous progression of cancerous severity due to the interaction of physical (ultraviolet radiation), chemical (smoking, mycotoxins, and heavy metals), and biological (microbial populations) carcinogens inspired scientists to develop a correlation between active therapeutic agents and cancer proliferation. This review highlights the molecular mechanism by which lycopene imparts its anticancerous role, focusing on clinical and animal trials to validate its effectiveness. The antioxidant profile of lycopene promotes anticancerous properties that reduce cancer prevalence by activating cell signaling pathways and gene expression (involved in cancer cell proliferation).

Anthropogenic dust pollution influences leaf and root morpho-anatomical traits by altering the metabolism and biochemical properties of indigenous vegetation.

The current investigation analyzed the impact of dust pollution from the stone crushing industry in the Kirana Hills of Sargodha on plant communities, with a focus on seasonal variations in plant metabolism, structure, and heavy metal accumulation at different study sites. The results revealed that heavy metal concentrations were notably higher at extreme dust sites, particularly during the winter season, indicating a significant impact of dust pollution on the environment. Soil analysis revealed distinct compositions across different sites and seasons, highlighting the variability in environmental conditions.

Global dynamics of robotic surgery research: a multi-method bibliometric investigation and focus on the top 100 most cited papers.

This study utilizes the Scopus database and adopts a multi-layered approach to provide a comprehensive and detailed overview of robotic surgery research. Specifically, three complementary strategies: (a) a title-abstract-keyword (TAK) search, (b) a title-specific search, and (c) a focused analysis of the top 100 most cited papers were employed. The TAK approach retrieved 49,026 publications, substantially surpassing the 8,029 identified via the title-only method, demonstrating that incorporating abstracts and keywords provides broader coverage.

Unexpected finding of cholecystogastric fistula in a patient undergoing laparoscopic cholecystectomy: A case report.

Background: Gallbladder stones are a common occurrence, with a prevalence of approximately 10% in the Pakistani population. A rare but potentially fatal complication of gallstones is cholecystogastric fistulas. The underlying mechanism involves chronic inflammation due to cholelithiasis, causing gradual erosion and eventually leading to fistula formation.

Determination of heavy metals and morphoanatomical characteristics of the monocots Aristida mutabilis and Cenchrus ciliaris in the dust-contaminated stone crushing industry of Sargodha, Pakistan.

The current investigation analyzed the population dynamics of vegetation in the severely dust-polluted environment of the stone crushing industry in the Kirana Hills of Sargodha. Data pertaining to dust levels, soil composition, and vegetation characteristics were systematically collected from all the study sites throughout the year to explore the seasonal fluctuations in the plant community structure and the underlying determinants of these variations. Heavy metal analysis revealed increased concentrations of all heavy metals at the most heavily dust-polluted sites, particularly during the winter season.

Trends and outcomes of different mechanical circulatory support modalities for refractory cardiogenic shock in Takotsubo cardiomyopathy.

Background: The use of mechanical circulatory support (MCS) devices in cardiogenic shock is growing. We aim to study trends and compare different MCS modalities in this population.

Methods: The National Readmission Database (2016-2020) was queried to identify TTC-CS requiring MCS.

Analysis of 11 bibliometric publications in the Journal of Robotic Surgery: a few suggestions.

Bibliometric research offers valuable insights into publication trends, citation dynamics, and research collaborations. The growing body of bibliometric literature reflects the dedication of numerous authors who have contributed significantly to our understanding of scientific progress. At the same time, the differences in methodology and scope can affect the depth and interpretation of findings.

Safety Study and Molecular Docking Analysis of Phyto-Constituents from Leaves: Insights into Dipeptidyl Peptidase-4 (DPP-4) Inhibition and Therapeutic Potential.

Background: Medicinal plants form the foundation of healthcare systems and modern medicine, offering powerful therapeutic potential to combat a wide range of chronic metabolic disorders.

Objective: Th present study evaluates the safety of leaf extracts using rodent modeling for 56 days. It also explores the molecular docking interactions of leaf phytoconstituents with the dipeptidyl peptidase-4 (DPP-4) receptor.

An unsupervised method for MRI recovery: deep image prior with structured sparsity.

Objective: To propose and validate an unsupervised MRI reconstruction method that does not require fully sampled k-space data.

Materials And Methods: The proposed method, deep image prior with structured sparsity (DISCUS), extends the deep image prior (DIP) by introducing group sparsity to frame-specific code vectors, enabling the discovery of a low-dimensional manifold for capturing temporal variations. DISCUS was validated using four studies: (I) simulation of a dynamic Shepp-Logan phantom to demonstrate its manifold discovery capabilities, (II) comparison with compressed sensing and DIP-based methods using simulated single-shot late gadolinium enhancement (LGE) image series from six distinct digital cardiac phantoms in terms of normalized mean square error (NMSE) and structural similarity index measure (SSIM), (III) evaluation on retrospectively undersampled single-shot LGE data from eight patients, and (IV) evaluation on prospectively undersampled single-shot LGE data from eight patients, assessed via blind scoring from two expert readers.

SURFACE COIL INTENSITY CORRECTION FOR MRI.

Modern MRI scanners utilize one or more arrays of small receive-only coils to collect k-space data. The sensitivity maps of the coils, when estimated using traditional methods, differ from the true sensitivity maps, which are generally unknown. Consequently, the reconstructed MR images exhibit undesired spatial variation in intensity.

DEEP IMAGE PRIOR WITH STRUCTURED SPARSITY (DISCUS) FOR DYNAMIC MRI RECONSTRUCTION.

High-quality training data are not always available in dynamic MRI. To address this, we propose a self-supervised deep learning method called deep image prior with structured sparsity (DISCUS) for reconstructing dynamic images. DISCUS is inspired by deep image prior (DIP) and recovers a series of images through joint optimization of network parameters and input code vectors.

Precision oncolytic viral therapy in colorectal cancer: Genetic targeting and immune modulation for personalized treatment (Review).

Colorectal cancer (CRC) is a leading health issue and treatments to eradicate it, such as conventional chemotherapy, are non‑selective and come with a number of complications. The present review focuses on the relatively new area of precision oncolytic viral therapy (OVT), with genetic targeting and immune modifications that offer a new future for CRC treatment. In the present review, an overview of the selection factors that are considered optimal for an oncolytic virus, mechanisms of oncolysis and immunomodulation applied to the OVT, as well as new strategies to improve the efficacy of this method are described.

A comprehensive review on the bioactivity and pharmacological attributes of .

, commonly known as Ashwagandha or Indian ginseng, is a highly valued medicinal plant in traditional systems of medicine. This review encompasses the bioactive constituents and pharmacological properties of , emphasising its potential in addressing numerous health conditions. The plant contains many bioactive compounds, such as withanolides, alkaloids, and saponins, exhibiting various biological activities.

Nutraceutical Potential of Anthocyanins: A Comprehensive Treatise.

Anthocyanins (Anthos; flower and kyanos; blue) are natural coloring compounds from the flavonoids class that include cyanidin, peonidin, delphinidin, malvidin, pelargonidin, and petunidin. Recently, the role of anthocyanins in disease prevention, especially inflammation, diabetes, cancer, neuro-disorders, hepato-renal protective, and immuno-modulation properties has been highlighted. The current review covered the literature on the pharmacokinetics and pharmacological effects of anthocyanins, especially absorption, distribution, metabolism, and excretion (ADME).