Lanthanum strontium cobalt ferrite [LaSrCoFeO] alloyed impedimetric sensing platform for human papillomavirus type 16 mutant DNA detection.

Human papillomavirus type 16 (HPV-16) is a leading cause of cervical cancer among women worldwide. This study presents an electrochemical impedance spectroscopy (EIS)-based biosensor for the sensitive and selective detection of HPV-16 mutant DNA. A single-stranded DNA probe complementary to the target sequence was immobilized on a gold interdigitated electrode (G-IDE) modified with lanthanum strontium cobalt ferrite LaSrCoFeO (LSCF) nanopowder to enhance charge transfer.

Green synthesis of high throughput hydrogen peroxide via sub-atmospheric plasma-water interaction.

Plasma-activated water (PAW), enriched with reactive species such as hydrogen peroxide (HO), presents a sustainable and versatile solution for wastewater treatment, disinfection, agriculture, and biomedical applications. This study investigates the effects of key plasma parameters - treatment time, input power, water purity, and chamber pressure - on HO production. A statistical framework combining response surface methodology (RSM), regression analysis, ANOVA, effect estimation, and marginal means was employed to model and analyze these influences.

Selection, characterization and the application of the RNA aptamer in the capture assay of Erythropoietin (EPO).

Erythropoietin (EPO) is an erythropoietic growth factor that induces the production of red blood cells. However, this protein is also extensively manipulated by athletes to illegally enhance their performance, a phenomenon known as doping. Generating a feasible molecular recognition element against EPO would be beneficial for doping detection.

Microalgae and Human Disorders: Mechanistic Insights and Therapeutic Potential.

Microalgae, which are primarily autotrophic organisms, have caught the spotlight due to their impressive growth rates and broad distribution. They're particularly exciting because of their biocompatibility and the wide range of biological activities they offer. Species like Spirulina and Chlorella exhibit high antioxidant, anti-inflammatory, antimicrobial, anticancer, antihypertensive, anti-lipidemic, and anti-diabetic properties, making them a promising element in therapeutics.

Sensitive detection of dengue serotype-4 on lignin-derived graphene nanofibre and manganese oxide composite by DNA-sensing.

This research addresses the critical challenge of achieving precise DNA detection in complex biological samples by developing a novel, eco-friendly dengue virus serotype 4 biosensor. Utilizing laser-scribed graphene nanofibers derived from sustainable oil palm lignin, a cost-effective alternative to conventional graphene, the biosensor leverages the material's high surface area and conductivity for enhanced DNA immobilization and signal transduction. While lignin-derived graphene's heterogeneous structure poses challenges to electrochemical performance, this study overcomes these limitations by synthesizing laser scribed-graphene nanofibres (LSGNF) decorated with manganese oxide nanoparticles.

Recent Progress in Multi-Analytes Recognition Reinforced by Graphene Derivatives for Cardio Health Assessments.

The escalating prevalence of cardiovascular diseases globally call for a low-cost monitoring technology for an immediate intervene and diagnoses. Advance multiplexed biosensors reinforced by graphene derivatives marks a significant progression in the field of cardiovascular health assessments. The graphene derived biosensors are designed specifically for fast detection of cardiac biomarkers with high precision to evaluate cardiovascular health.

Antibody-aptamer Complementation: Advancing Biosensing for Disease Monitoring.

A biosensor is a biological device designed to convert biological responses into an electrical signal, which has diverse applications across various fields, including diagnostics, environmental monitoring, food safety, and drug discovery. Among these, biosensing technology has achieved remarkable success in medical diagnostics. To detect target molecules for various probe molecules, such as nucleic acids, peptides, antibodies, and proteins are widely used.

Neurological Inflammation in Parkinsonism: Current Prognosticative Diagnostics and Pitfalls.

Parkinson's disease (PD) is a persistent neurological degenerative condition that can significantly alter one's quality of life. This condition affects the substantia nigra, the region of the brain that contains dopamine-producing neurons. It is a disorder of the central nervous system that arises when nerve cells, or neurons, in this brain area are damaged or die.

Artificial Intelligence in Oral Cancer Diagnosis: Overcoming Challenges for Enhanced Outcomes.

Oral-related cancer accounts for the sixth leading cause of cancer-related deaths and one death every hour in the United States [1]. Several factors may contribute to the formation of oral tumors, including tobacco use, alcohol consumption, unhealthy diets low in fruits and vegetables, age, and general lifestyle. Smoking and alcohol consumption, in particular, have been found to contribute 80% and 61% to oral cancer in men and women, respectively [2].

Advancements in Modified Electrodes with Electrochemical Sensors for Detecting Acetaminophen and Caffeine: An Update.

Acetaminophen and caffeine are analgesic or psychoactive drugs in human life that plays a major role in food and medicinal chemistry. Caffeine increases the efficacy of acetaminophen by improving its absorption, thereby prolonging analgesic action. Caffeine might exacerbate symptoms of anxiety if being prone to them.

Electro-Sensing Analysis for Parkinson's Disease Biomarker on Dual-Electrode Surface: Complemented by Molecular Docking.

This study was designed to improve the sensitivity, specificity, and selectivity of the electrochemical method of detecting Parkinson's disease by identifying alpha-synuclein as a biomarker using gold interdigitated electrodes (AuIDEs with and without surface modified with zinc oxide (ZnO). AuIDE modified with zinc oxide and AuIDE without zinc oxide were characterized using a scanning electron microscope, 3D profilometers, and a high-power microscope. Current-voltage measurements were performed for antigen-antibody interaction and targeted detection using a Keithley 6482 Picoammeter.

Nanomaterial Enhances the Performance of Amyloid-beta Biosensing for Alzheimer's Disease Diagnosis.

Background: Highly sensitive, accurate, and low-cost detection systems are gaining interest for early intervention in the progression of Alzheimer's disease (AD). Amyloid-beta (Aβ), a peptide highly involved in the progression of AD, is found in abundance in patients with severe AD.

Objective: This research focused on developing an Aβ oligomer (AβO) biosensor using a single-walled carbon nanotube-modified (SWCN) interdigitated electrode (IDE) sensor.

Comparative Glycoproteomic Analysis of Mouse 4T1 Breast Cancer Model.

Background: Glycosylation is a post-translational modification process that plays a fundamental role in malignant transformation. Moreover, aberrant glycosylation is known to be associated with cancer progression. Thus, the characterization of cancer-specific protein glycosylation profiles might reveal important diagnostic and/or prognostic biomarkers for cancer.

Current Attainments on Nanobiosensors for Diagnosing Atherosclerosis Biomarkers.

Atherosclerosis is a chronic disease caused by inflammation in the blood vessel wall, which leads to plaque formation in the endothelial lining. Preexisting atherosclerosis contributes to various cardiovascular problems, including myocardial infarction, congestive cardiac failure, arrhythmias, and acute coronary syndrome, all of which are associated with higher postoperative mortality and morbidity. Rupturing of atherosclerosis poses a significant health concern as triggering a heart attack.

Challenges in selecting edible coating materials for fruit postharvest preservation and recent advances in edible coating techniques: a review.

Fruits are a vital component of a healthy diet, offering essential nutrients and appealing sensory attributes. However, their high perishability leads to significant postharvest losses, which are influenced by factors such as physiological changes, microbial spoilage, and inadequate handling practices. These losses not only reduce fruit quality and marketability but also contribute to increased food waste.

Fatty Acids and Benzene Derivatives Partitioned From Marine-Derived Bacillus safensis: Novel Agents Against Methicillin-Resistant Staphylococcus aureus.

The global rise in antimicrobial resistance poses significant challenges to treating infectious diseases, particularly those caused by methicillin-resistant Staphylococcus aureus (MRSA) in healthcare settings. This research explores the potential of halophilic microorganisms as a source of novel antimicrobial compounds, focusing on Bacillus safensis isolated from saltpan soils in the Tuticorin coastal region, India. Among 158 isolates, B.

Internet of Medical Things (IoMT) for Alzheimer Patient's Outcome.

The Internet of Medical Things (IoMT) is a network system that connects devices with medical and healthcare for the ultimate aim of collecting, transmitting, and analyzing the acquired data in the presence of the internet. A wide range of equipment and monitoring systems have been generated with IoMT, and they permit real-time monitoring, sharing the data, analysis, patient care, and for efficient operation. At the advanced level, it is highly facilitated with remote patient digital monitoring and telemedicine.

Clinical Markers and Diagnostics for Diagnosing Cerebral Infarction.

Cerebral or brain infarction is a pathological process that restricts or blocks the supply of blood to the brain due to occlusion or narrowing of cerebral blood vessels. At present, computed tomography (CT) and magnetic resonance imaging (MRI) are commonly used to image cerebral infarction. Along with imaging, numerous non-invasive external brain monitoring tools are being developed that use a variety of technologies to act as sensors for neurological disorders, including stroke.

Potential Anti-Filarial Molecules Against ATP Binding Site of MurE Enzyme: A Molecular Docking and Dynamics Approach to Combat Lymphatic Filariasis.

Lymphatic filariasis (LF) is a mosquito-borne disease caused by parasitic nematodes Brugia malayi, Brugia timori, and Wuchereria bancrofti. The drugs available are effective in several cases, and the absence of vaccination is the crucial factor hindering the elimination of LF. The UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2,6-diaminopimelate ligase (MurE) plays an important role in the peptidoglycan biosynthesis of Wolbachia endosymbiont B.

MnO Tetrahedral with Carbonyldiimidazole Nanoflower Deposition on Laser-Scribed Graphene for Selective Bio-Capture.

Dengue fever, a mosquito-borne viral infection, poses a significant global health challenge, particularly in tropical and subtropical regions. The absence of non-effective vaccines and specific treatments underscores the need for advanced diagnostic tools for early detection and management. This study presents a novel biosensor for detecting dengue virus type 4 (DENV-4) by combining carbonyldiimidazole nanoflower (CDI-NF) with MnO on laser-scribed graphene (LSG).