Publications by authors named "Su-Young Kim"
Treatment Outcomes of Complex Pulmonary Disease with a 2-drug Daily Regimen Using Macrolide and Ethambutol.
Open Forum Infect Dis
June 2025
Background: Limited data exist on the treatment outcomes of a 2-drug daily regimen of macrolide and ethambutol in patients with complex pulmonary disease (MAC-PD).
Methods: An outcome analysis was performed on 108 patients with MAC-PD who underwent at least 12 months of treatment with macrolides and ethambutol. Microbiological responses, antibiotic resistance rates, and recurrence rates linked to the regimen were analyzed.
Efficacy of a novel one-step knife compared to conventional knife for colorectal endoscopic submucosal dissection: a prospective multicenter randomized controlled trial.
Int J Colorectal Dis
May 2025
Purpose: For the treatment of advanced colorectal neoplasms, colon endoscopic submucosal dissection (ESD) is a crucial technique, although it is time-consuming. The purpose of this study was to evaluate the efficacy of a recently developed one-step knife (OSK) in colon ESD and compare its performance with that of a conventional knife (CK).
Methods: Between July 2020 and November 2021, patients scheduled to undergo colorectal ESD were randomly assigned to either the OSK group or the CK group.
Background/aims: To analyze the characteristics of the sputum microbiota of patients with nontuberculous mycobacteria pulmonary disease (NTM-PD) based on treatment status.
Methods: Twenty-eight sputum samples from 14 patients with NTM-PD, including 14 samples from the microbiologically cured group (7 at baseline and 7 during follow-up) and 14 from the treatment-refractory group (7 at baseline and 7 during follow-up) were included in this study. Bacterial microbiota was analyzed by sequencing the V3-V4 region of the 16S rRNA gene.
Natural killer (NK) cells produce various cytokines, including interleukin (IL)‑1β, IL‑6, IL‑10, IL‑12, interferon γ, tumor necrosis factor α and transforming growth factor β, which are critical in modulating immune responses. NK cell‑conditioned medium (NK‑CdM), rich in cytokines, has potential applications in therapy and healing. The present study aimed to investigate the protective effect of NK‑CdM against ultraviolet B (UVB)‑mediated photoaging using and models.
View Article and Find Full Text PDFAmeliorative Effects of Escin on Inflammation via Glucocorticoid Receptor (GR) in Atopic Dermatitis (AD) Mouse Model.
J Microbiol Biotechnol
March 2025
Atopic dermatitis (AD) is a chronic, relapsing inflammatory skin disease characterized by intense itching. Escin, derived from , has several pharmacological functions, including anti-inflammatory and anti-viral effects, and exhibits glucocorticoid-like actions in inflammatory responses. However, its impact on AD has not been extensively studied.
View Article and Find Full Text PDFBackground/aims: We investigated the clinical practice patterns of Korean endoscopists for the endoscopic resection of colorectal polyps.
Methods: From September to November 2021, an online survey was conducted regarding the preferred resection methods for colorectal polyps, and responses were compared with the international guidelines.
Results: Among 246 respondents, those with <4 years, 4-9 years, and ≥10 years of experience in colonoscopy practices accounted for 25.
Establishment of an oral burn model in streptozotocin-induced diabetic rats.
Maxillofac Plast Reconstr Surg
December 2024
Background: Oral ulcers are painful mucosal lesions prone to infection and inflammation. To evaluate the effectiveness of treatments, a suitable experimental animal model with an appropriate healing period is required. The aim of this study was to develop an animal model for oral ulcer research by comparing oral burn wounds of different sizes and locations in diabetic rats.
View Article and Find Full Text PDFLong-term clinical course of complex pulmonary disease patients with treatment failure.
Antimicrob Agents Chemother
December 2024
Article Synopsis
- Some patients with complex pulmonary disease (MAC-PD) still experience treatment failure despite following guidelines; an analysis of 271 patients showed that 51% needed retreatment after stopping therapy.
- Patients were divided into retreatment and stable groups, with several factors like elevated erythrocyte sedimentation rates, presence of lung cavities, and extent of bronchiectasis linked to the need for retreatment.
- This study highlights that about half of the patients who stopped antibiotics may eventually require them again, suggesting that the severity of lung damage influences treatment decisions.
Article Synopsis
- Multimorbidity negatively impacts health-related quality of life (HRQoL), particularly in patients with hypertension, but the exact reasons for this effect were not well understood.
- This study explored how depressive symptoms and treatment burden act as mediators between the number of diseases a patient has and their HRQoL, analyzing differences between younger (<60 years) and older (60+) age groups.
- Results indicated that while there is a direct link between disease burden and HRQoL, depressive symptoms play a larger mediating role than treatment burden in older patients, highlighting the need for age-specific interventions that address both factors.
Scaling and estimation of latent growth models with categorical indicator variables.
Psychol Methods
September 2024
Article Synopsis
- * Understanding the scaling process is crucial because different parameter constraints change the model's scale, affecting the estimation results and their interpretations.
- * This study aims to clarify the scaling process, organize parameter constraint methods, and demonstrate the importance of these methods on the interpretation of LGMs through a simple example.
Article Synopsis
- Hair loss can happen to both boys and girls, no matter their age.
- Myokines are special substances produced when we exercise, and some of them, like VEGF, IGF-1, and FGF, help hair grow.
- This study found that irisin, another myokine, can also boost hair growth by activating a certain pathway in cells, making it a possible new way to treat hair loss.
Article Synopsis
- Mycobacterium avium complex pulmonary disease (MAC-PD) shows varied clinical outcomes, which are linked to different immune profiles in patients.
- A study of 21 MAC-PD patients identified three clinical groups based on disease progression, revealing that group C (progressive disease) had fewer natural killer (NK) cells and more classical monocytes compared to groups A (spontaneous culture conversion) and B (stable without treatment).
- Specific genes and immune markers were found to be up-regulated or down-regulated in different groups, providing insights into how immune responses may affect the progression of MAC-PD, potentially leading to new treatment strategies.
Article Synopsis
- - The study aimed to evaluate the risk of cardiovascular disease (CVD) in survivors of gastrointestinal (GI) cancer, as previous research on this group has been limited.
- - Data collected from the Korean National Health and Nutrition Examination Surveys showed that GI cancer survivors had a lower risk of atherosclerotic cardiovascular disease (ASCVD) compared to cancer-free individuals, especially among those who engaged in sufficient physical activity.
- - Results highlighted that adequate aerobic exercise and high quality of life scores were associated with significantly reduced ASCVD risk in GI cancer survivors, suggesting the importance of physical activity for their cardiovascular health.
Article Synopsis
- The study investigates the effects of low body mass index (BMI) on the progression of Mycobacterium avium complex pulmonary disease (MAC-PD) using a specialized mouse model.
- It found that a low protein diet (LPD) worsens MAC-PD progression by disrupting lipid metabolism, leading to increased fatty acid levels and macrophage lipid accumulation during MAC infection.
- The research suggests that improving nutrient intake could help manage MAC-PD, highlighting the importance of host immune cell metabolism and the potential for targeting CD36 pathways as a treatment strategy.
Article Synopsis
- - The study explored why adults who smoke also use e-cigarettes, focusing on different sociodemographic groups, with data collected from surveys conducted in 2016 and 2020.
- - In 2020, the main motivations for using e-cigarettes were curiosity (62.8%), perceived reduced harm compared to smoking (45.4%), and flavor (43.2%), with less emphasis on quitting or reducing smoking.
- - Compared to 2016, the reasons for using e-cigarettes shifted from goal-oriented (like quitting) to non-goal-oriented motivations (like curiosity), with 53.3% of users in 2020 expressing no desire to quit or cut back on smoking.
Article Synopsis
- The study analyzed sputum samples from NTM-PD patients to compare the microbiomes of those with stable disease versus those requiring antibiotic treatment.
- In the stable group, certain bacteria were more prevalent, while no significant changes were found between baseline and follow-up samples.
- The findings suggest specific bacterial profiles may be associated with disease stability, indicating a potential role for the microbiome in managing NTM-PD.
A survey of current practices in post-polypectomy surveillance in Korea.
Intest Res
April 2024
Article Synopsis
- A study analyzed how Korean endoscopists manage post-polypectomy colonoscopy surveillance, focusing on their preferred intervals and when to stop surveillance based on survey responses.
- The survey, conducted with 196 endoscopists, found varying surveillance recommendations depending on the type and quantity of polyps removed, with many preferring a 1-year to 5-year interval based on specific cases.
- Only about 30.7% of respondents adhered to the latest US guidelines, indicating a need for more individualized approaches to improve compliance.
Article Synopsis
- The study investigates the prevalence and perceptions of flavour capsule cigarettes (FCCs) among adult smokers in five different countries, highlighting significant differences in usage rates.
- Data was collected from surveys conducted in Brazil, Japan, South Korea, Malaysia, and Mexico, revealing various correlates of FCC use, such as gender, age, education, and smoking habits.
- The findings emphasize the need for regulatory efforts to manage the popularity and appeal of FCCs due to their high prevalence in certain regions.
Background/aim: We aimed to validate clinical decision support tools (CDSTs) to predict real-life effectiveness of vedolizumab (VDZ) in patients with inflammatory bowel disease.
Methods: We retrospectively enrolled patients with Crohn's disease (CD) or ulcerative colitis (UC) treated with VDZ at 10 tertiary referral centres in Korea between January 2017 and November 2021. We assessed clinical remission (CREM) and response (CRES), corticosteroid-free clinical remission (CSF-CREM) and response (CSF-CRES), biochemical response based on C-reactive protein (BioRES[CRP]) and faecal calprotectin (BioRES[FC]), endoscopic healing (EH), and the need to optimise or switch drugs based on CDST-defined response groups.
Article Synopsis
- Urban Particulate Matter (UPM) contributes to skin aging and inflammation by activating specific skin cell receptors, particularly the TRPV1 channel.
- Oleic acid, a type of unsaturated fatty acid, demonstrates protective effects against UPM-induced skin damage by inhibiting key signaling pathways like AhR and TRPV1.
- The study suggests that oleic acid helps reduce inflammation and promotes cell growth in skin cells exposed to UPM by lowering the activity of harmful molecules and proteins linked to damage and aging.
Article Synopsis
- A study in South Korea examined public support for six tobacco control policies aimed at reducing tobacco use, including limiting nicotine content and banning cigarette sales under certain conditions.
- Data was collected from 4,740 adults categorized by their nicotine use, revealing that support for limiting nicotine was highest (68.4%), while support for banning sales with alternatives was lowest (45.0%).
- Overall, there is strong public backing for these policies, indicating a need for further research on effective implementation strategies.
An anti-mycobacterial conjugated oligoelectrolyte effective against .
Sci Transl Med
February 2024
Article Synopsis
- * Researchers discovered a new compound called COE-PNH, derived from conjugated oligoelectrolytes, which effectively kills the bacterium and shows low chances of resistance.
- * COE-PNH works by damaging the bacteria's protective structures and has demonstrated safety and effectiveness in animal models, indicating its potential as a new treatment option for these infections.
Article Synopsis
- Quantum dot light-emitting diodes (QLEDs) often face issues with charge imbalance and exciton quenching when using ZnO nanoparticles as an electron injection layer.
- To address these problems, an arginine interlayer was added to the ZnO nanoparticles, which improved charge balance by suppressing electron injection and prevented exciton quenching due to its insulating properties.
- The modified inverted QLEDs with a 20 nm-thick arginine interlayer showed significant improvements in performance, including a 2.22-fold increase in current efficiency and a 2.28-fold increase in external quantum efficiency compared to those without the interlayer.
Water Extract (APWE) Protects Against UVB-Induced Photoaging via MAPK/AP-1 and TGFβ-Smad Pathway.
Ann Dermatol
February 2024
Article Synopsis
- Silver vine extract, known as PB203, has traditional uses in oriental medicine for treating gout and inflammation, and this study investigates its potential anti-photoaging effects.
- The research involved measuring the antioxidant effects of PB203 on UVB-irradiated skin cells and examining its impact on wrinkle formation in mice, focusing on various skin proteins and enzymes.
- Results showed that PB203 reduces harmful reactive oxygen species, maintains collagen levels, inhibits wrinkle formation, and enhances the skin's barrier, suggesting its potential as a therapeutic agent for UVB-induced skin aging.
Article Synopsis
- Ozone is a reactive molecule used in skin treatment, but there’s limited research on its effectiveness for atopic dermatitis (AD).
- Ozonated sunflower oil (OSO) showed promising effects by reducing inflammatory markers in mouse cells and alleviating AD symptoms in a mouse model.
- The study suggests OSO can help treat AD-related skin damage through its anti-inflammatory and antioxidant properties, making it a potential therapeutic option.