Effect of tacrolimus with mycophenolate mofetil or cyclophosphamide on the renal response in systemic lupus erythematosus patients.

Objective: This study aimed to determine the therapeutic efficacy of tacrolimus (TAC) with mycophenolate mofetil (MMF) or cyclophosphamide (CYC) on the renal response in systemic lupus erythematosus (SLE) patients.

Methods: A retrospective cohort study based on medical data was conducted among SLE patients who took at least one of the following medicines in 2010-2021: TAC, MMF and CYC. The odds ratio (OR) and 95% confidence interval (CI) were calculated, and the synergistic interaction was estimated using logistic regression models.

Factors associated with 25-hydroxyvitamin D level in Chinese hospitalized patients with systemic lupus erythematosus: a retrospective cohort study.

We aimed to investigate the factors associated with vitamin D deficiency and changes in 25 (OH)D levels, as well as the impact of those changes on disease activity and renal function among SLE patients. This retrospective cohort study was based on the medical records of SLE patients hospitalized between 2010 and 2021. We collected relevant information from this patient population.

Association Between Mycophenolate Mofetil Use and Subsequent Infections Among Hospitalized Patients with Systemic Lupus Erythematosus: A Nested Case-Control Study.

Introduction: The association between mycophenolate mofetil (MMF) and infection in patients with systemic lupus erythematosus (SLE) has not been clarified. This study evaluated the degree and factors in effect of MMF use on infection in patients with SLE.

Methods: A hospitalized-based observational study was conducted to collect medical records on patients with SLE during 2010-2021.

Biodegradable smart materials with self-healing and shape memory function for wound healing.

Notwithstanding the rapid development of suture elastomers to meet the needs of practical surgery, utilizing the elastomers' self-healing function as a surgical suture to facilitate the healing of wounds has not been addressed. Here, a biodegradable aliphatic polycarbonate smart elastomer, mPEG--PMBC , was synthesized from aliphatic polycarbonate monomer with methoxy polyethylene glycol (mPEG, 5.0 kDa) as initiator, which exhibited excellent mechanical properties, highly efficient self-repairing, and remarkable shape memory behavior.

An improved self-supervised learning for EEG classification.

Motor Imagery EEG (MI-EEG) classification plays an important role in different Brain-Computer Interface (BCI) systems. Recently, deep learning has been widely used in the MI-EEG classification tasks, however this technology requires a large number of labeled training samples which are difficult to obtain, and insufficient labeled training samples will result in a degradation of the classification performance. To address the degradation problem, we investigate a Self-Supervised Learning (SSL) based MI-EEG classification method to reduce the dependence on a large number of labeled training samples.

Construction of multi-layered Zn-modified TiO coating by ultrasound-auxiliary micro-arc oxidation: Microstructure and biological property.

Surfaces with desirable cytocompatibility and bactericidal ability are favoured for orthopaedic implants to stimulate osteogenic activity and to prevent implant-associated infection. In this work, we creatively introduce ultrasonic vibration (UV) to micro-arc oxidation (MAO) process and explore its influence on the microstructure, corrosion property and biological responses of Zn-modified TiO coating. With the introduction of UV, a uniform surface layer with homogeneously-distributed clusters could be produced as the outer layer, which possesses a fusion band with the underlying TiO.

Dynamic changes of activator protein 1 and collagen I expression in the sclera of myopia guinea pigs.

Aim: To investigate the dynamic changes of activator protein 1 (AP1) and collagen I expression in the sclera of form-deprivation myopic model in guinea pigs.

Methods: A form-deprivation myopic model in guinea pigs were established with the left eye covered for 2 to 6wk (FDM group). Normal control group (=25) were untreated.

TRPV4 regulates migration and tube formation of human retinal capillary endothelial cells.

Background: Ca entry plays an important role in modulating endothelial cell migration and tube formation. Transient receptor potential cation channel subfamily V member 4 (TRPV4) is a Ca-permeable channel that is widely expressed in endothelial cells. It has been reported that TRPV4 is expressed in HRCECs and regulates Ca entry.

Expression and role of specificity protein 1 in the sclera remodeling of experimental myopia in guinea pigs.

Aim: To study the expression of collagen I and transcription factor specificity protein 1 (Sp1), a transforming growth factor-β1 (TGF-β1) downstream target, and reveal the impact of the TGF-β1-Sp1 signaling pathway on collagen remodeling in myopic sclera.

Methods: Seventy-five 1-week-old guinea pigs were randomly divided into normal control, form deprivation myopia (FDM), and self-control groups. FDM was induced for different times using coverage with translucent latex balloons and FDM recovery was performed for 1wk after 4wk treatment; then, changes in refractive power and axial length were measured.

[Clinical research of intraoperative floppy iris syndrome during operation].

Intraoperative floppy iris syndrome (IFIS) has been recently identified as a new small pupil syndrome during phacoemulsification. This syndrome is characterized by three intraoperative features: a flaccid iris stroma that undulates and bellows in response to intraocular fluid currents; a propensity for the floppy iris stroma to prolapse toward the tip of phacoemulsification and side-port incisions despite proper wound construction; and progressive intraoperative pupil constriction despite standard preventive preoperative pharmacologic measures designed to prevent this. It is now mostly considered that IFIS is associated with the use of tamsolusin, a highly selective alpha-1A receptor antagonist for the treatment of benign prostatic hypertrophy.

Rapid method for the determination of amino acids in serum by capillary electrophoresis.

A rapid method for the determination of amino acids in serum is presented. The derivatization of amino acids with 2,4-dinitrofluorobenzene was performed in 0.5 M sodium borate (pH 9.