Study on the Mechanical and Mesoscopic Properties of Rockfill Under Various Confining Pressures.

To investigate the mechanical response characteristics of damming rockfill materials under different confining pressure conditions, this study integrates laboratory triaxial compression tests and PFC numerical simulations to systematically analyze their deformation evolution and failure mechanisms from both macroscopic and microscopic perspectives. Laboratory triaxial test results demonstrate that as the confining pressure increases, the peak deviatoric stress rises significantly, with the shear strength of specimens increasing from 769.43 kPa to 2140.

Effect of integrin‑linked kinase gene silencing on microRNA expression in ovarian cancer.

Integrin‑linked kinase (ILK) is overexpressed in ovarian cancer (OC), and ILK gene silencing results in apoptosis in OC cells. In the present study, the mechanism by which ILK induces apoptosis was explored from the perspective of microRNA (miRNA) expression. Alterations in the global miRNA expression profile were detected using a miRNA microarray after OC cells were transduced with an ILK small hairpin RNA lentivirus.