Association of coarctation of aorta with Turner syndrome: a case report.

Background: Monosomy 45,X is commonly associated with congenital heart defects, particularly coarctation of the aorta (CoA). In this case, the patient developed respiratory distress due to hemodynamic instability from a large bidirectional patent ductus arteriosus (PDA) shunt and systemic hypoperfusion secondary to CoA, which complicated diagnosis and management.

Case Presentation: We report a 34-week premature female neonate weighing 1.

A Multilamellar, Thermoreversible, Phase-Selective Galactose-Triazole Organogelator: Role of Noncovalent Interactions and Porous Nanostructure in Environmental Remediation.

This article describes the design and synthesis of an efficient galactose-triazole-based reversed N-nucleoside as a thermoreversible, low molecular weight organogelator 8a. The gelator 8a shows a phase-selective behavior toward ethyl acetate with respect to water. Powder X-ray diffraction, scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), and UV results show that the xerogel has a multilamellar structure due to supramolecular forces identified as H-bonding, van der Waals interactions, and π-π stacking.

An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies.

Introduction: Cytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes.

Results/methods: By combining immunotoxicology and systems biology approaches, we offer a novel and integrative conceptual model of CRS as an adverse outcome (AO), induced by five different immunomodulatory biotherapies: 1) chimeric antigen receptor (CAR) T cells, 2) checkpoint inhibitors, 3) T cell engaging bispecific modalities, 4) monoclonal antibodies targeting and activating T cell receptors, and 5) FcγR activating monoclonal antibodies. This model uniquely integrates multiple CRS-inducing therapies into a unified framework, offering a comprehensive mechanistic representation of CRS pathophysiology.

Ethnomedicinal documentation of plants used for gastrointestinal disorders in Sahiwal District Pakistan.

The gastrointestinal tract is regarded as vulnerable due to frequent exposure to a variety of foods. Diarrhea, ulcers, constipation, and parasitic infections are considered to be the most prevalent disorders worldwide. The present study was conducted in the District Sahiwal to appraise the local flora for the treatment of a diverse range of gastrointestinal disorders (GIDs) for the first time.

Novel PNLDC1 mutations underlie nonobstructive azoospermia in humans and mice.

PIWI-interacting RNAs (piRNAs) are small regulatory RNAs (21-35 nucleotides) exclusively expressed in germ cells, where they play a critical role in transposable element repression and post-meiotic gene regulation. The poly(A)-specific RNase-like domain-containing 1 (PNLDC1) protein is essential for piRNA maturation, specifically in 3'-end trimming. Disruption of PNLDC1 has been implicated in nonobstructive azoospermia (NOA) and male infertility.

Dissolving microneedle patches for transdermal delivery of paroxetine: studies and its PBPK modeling.

Background: Paroxetine HCl (PRX-HCl), an antidepressant, has poor water solubility and low oral bioavailability with 50% being metabolized in the liver. The oral formulations have multiple side effects. The present work aimed to develop dissolving microneedle patches (MNPs) of PRX-HCl to resolve low bioavailability and side effect issues while achieving enhanced transdermal delivery.

Applications of benchtop and portable spectroscopy techniques for food quality monitoring.

Food safety and quality have become major worldwide issues. Because of their quickness, effectiveness, and non-destructive nature, spectroscopy methods are essential for guaranteeing the safety and quality of food items. These techniques include Fourier transform infrared (FTIR), Infrared (IR), Raman spectroscopy, near-infrared (NIR), and Fluorescence spectroscopies, which can be used to evaluate food composition analysis, food adulteration, spoilage indicators, and various levels of contamination.

Deterministic Structural Distortion in Mn-Doped Layered Hybrid Lead Bromide Perovskite Single Crystals.

Dilute magnetic doping in wide-bandgap semiconductors has attracted significant interest due to its potential for tailored optical, spintronic, and spin-photonic properties. While extensive research has explored the optical and magnetic properties of these doped systems, the exact nature of dopant-induced structural properties, particularly in high-quality single crystals, requires further investigation. Here, we demonstrate the synthesis of Mn-doped (BA)PbBr (BA=butylammonium) single crystals with well-defined crystal habits and no grain boundaries, enabling controlled investigation into significant crystal deformation as a function of Mn incorporation.

A strain defined as a novel species in the genus co-harboring chromosomal associated (X3) and plasmid associated from a beef cattle farm in Hebei, China.

Introduction: The co-existence phenomenon of antibiotic resistance genes (ARGs), particularly of last-resort antibiotics in multi-drug resistant (MDR) bacteria, is of particular concern in the least studied bacterial species.

Methods: In 2023, strain M2 was isolated from the sludge sample at a commercial bovine farm in Hebei province, China, using a MacConkey plate containing meropenem. PCR amplification and Sanger sequencing verified it co-carrying and (X) genes.

Carboxymethyl chitosan-immobilized silver nanoparticles for intravesical instillation: A strategy to prevent catheter-associated urinary tract infections.

Developing effective strategies to prevent biofilm formation on urinary catheter surfaces is critical for reducing catheter-associated urinary tract infections (CAUTIs) in clinical settings. In this study, we synthesized carboxymethyl chitosan-immobilized silver nanoparticles (AgNPs@CMCS) through a facile hydrothermal reduction method under alkaline conditions. Comprehensive in vitro characterization demonstrated that AgNPs@CMCS possesses broad-spectrum and efficient antimicrobial activity through a multimodal antibacterial mechanism.

Utilizing CBNet to effectively address and combat cyberbullying among university students on social media platforms.

Cyberbullying can profoundly impact individuals' mental health, leading to increased feelings of anxiety, depression, and social isolation. Psychological research suggests that cyberbullying victims may experience long-term psychological consequences, including diminished self-esteem and academic performance. The widespread use of social media platforms among university students has raised major concerns over cyberbullying, which can have detrimental effects on student mental well-being and academic performance.

Integrated physiological, metabolomic, and transcriptomic responses of maize (Zea mays) and soybean (Glycine max) to nanoplastic-induced stress.

The widespread use and degradation of agricultural plastics lead to the accumulation of nanoplastics (NPs) and soil contamination, posing growing risks to agroecosystems. This study investigated the differential physiological and molecular responses of maize (Zea mays) and soybean (Glycine max) to polyethylene nanoparticles (PE-NPs) and polypropylene nanoparticles (PP-NPs), each within the size range of 20-50 nm, at concentrations of 50 and 500 mg/kg of soil. Over a 45-day exposure period, at 500 mg/kg concentration, both NPs types significantly suppressed plant height and fresh biomass in both maize and soybean, with PP-NPs demonstrating greater toxicity in soybean than in maize.

Exploring the prognostic role and expression patterns of FAM3A family genes in kidney renal clear cell carcinoma.

Kidney renal clear cell carcinoma (KIRC) is the most common subtype of kidney cancer, characterized by complex molecular alterations. The FAM3 gene family, comprising FAM3A, FAM3B, FAM3C, and FAM3D, has been implicated in various cancers, but their roles in KIRC are not well understood. This study investigated the expression, diagnostic potential, and functional significance of FAM3 family genes in KIRC.

Transcatheter Versus Surgical Approach for the Treatment of Aortic Stenosis in Patients With Concomitant Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Aortic stenosis (AS) with concomitant coronary artery disease (CAD) requires an approach that addresses both valvular and coronary pathology. While surgical aortic valve replacement (SAVR) with coronary artery bypass graft (CABG) has long been the standard treatment, transcatheter aortic valve replacement (TAVI) with percutaneous coronary intervention (PCI) has become a less invasive alternative. This meta-analysis compares the clinical outcomes of TAVI + PCI versus SAVR + CABG in patients with AS and concomitant CAD.

Recent Advances in Functionalized Carbon Quantum Dots Integrated with Metal-Organic Frameworks: Emerging Platforms for Sensing and Food Safety Applications.

Carbon quantum dots (CQDs), with their excellent photoluminescence, tunable surface chemistry, and low toxicity, have emerged as versatile nanomaterials in sensing technologies. Meanwhile, metal-organic frameworks (MOFs) possess exceptionally porous architectures and extensive surface areas, and tunable functionalities ideal for molecular recognition and analyte enrichment. The synergistic integration of CQDs and MOFs has significantly expanded the potential of hybrid materials with enhanced selectivity, sensitivity, and multifunctionality.

Genomic and phylogeographical analysis revealed CTX-M-55 producing ST10 and ST2325 clones of One Health concern from dairy farm waste in Gansu, China.

Extended-spectrum beta-lactamase (ESBL)-producing resists broad-spectrum cephalosporins, considered as a critical priority pathogen, and its presence in animals, humans, and the environment highlights its significance as a One Health issue. Dairy farm waste is a potential environmental contaminant and can serves as a significant reservoir for the emergence and spread of ESBL-producing , which belongs to One Health clones and poses a serious global threat. This study aimed to investigate the occurrence and genomic characteristics of ESBL-producing clones of One Health concern from dairy farm waste in Gansu, China.

Death Anxiety Among Chronic Disease Patients: The Role of Spiritual Well-Being, Mental Health Issues, and Religious Beliefs.

This paper has been designed to examine death anxiety among chronic disease patients through the role of spiritual well-being, mental health issues, religious beliefs, symptoms of depression, symptoms of anxiety, and life satisfaction among patients. The data have been collected from the patients facing chronic disease and admitted in public sector hospitals. A sample of 1377 patients has been drawn using a proportionate random sampling technique and a cross-sectional survey has been used as a technique of data collection.

Advances in Non-Thermal Processing of Meat and Monitoring Meat Protein Gels Through Vibrational Spectroscopy.

Meat is a vital source of high-quality proteins, amino acids, vitamins, and minerals essential for human health. Growing demand for healthier lifestyles and technological advancements has heightened the focus on meat products, whose quality depends on meat protein properties, such as texture, water holding capacity (WHC), and structural integrity. Non-thermal processing technologies are gaining attention for enhancing the gelation properties of meat protein gels (MPGs) by optimizing solubilization, denaturation, and aggregation while preserving nutritional and sensory qualities and avoiding the drawbacks of thermal treatments.

A novel caputo fractional model for english language learning: Analysis and simulation with bayesian regularization approach.

In this paper, a new Caputo discrete fractional model is introduced to capture the dynamics of English language learning. This model creates a strong foundation for examining language acquisition behaviors by including the learning process within the system. The proposed work not only presents an innovative discrete fractional model but also leverages machine learning techniques to estimate and analyze the learning process over time.

Clinical Profile and Outcome of Patients With Advanced Hepatocellular Carcinoma (HCC) Taking Sorafenib or Lenvatinib: Real-World Experience From a Low-Middle Resource Country.

Background and objective Hepatocellular carcinoma (HCC) incidence is high in Asian countries, and the age-standardized ratio in Pakistan is 7.6/100000 for males and 2.8/100000 for females, where patients often present with advanced-stage disease due to limited early detection.

Synthesis and optimization of fluoxetine-loaded polymeric nanoparticles for dual therapeutic applications in cancer and depression.

Background: Fluoxetine, an antidepressant, has shown potential anticancer effects. However, its therapeutic efficacy is limited by its poor bioavailability and rapid metabolism. Nanotechnology is advancing medicine, particularly in developing suitable drug delivery systems to improve therapeutic effects and reduce drug side effects.

A novel frameshift variant in AXDND1 may cause multiple morphological abnormalities of the sperm flagella in a consanguineous Pakistani family.

The syndrome of multiple morphological abnormalities of the sperm flagella (MMAF) is one of the most serious kinds of sperm defects, leading to asthenoteratozoospermia and male infertility. In this study, we use whole-exome sequencing to identify genetic factors that account for male infertility in a patient born from a consanguineous Pakistani couple. A homozygous frameshift mutation (c.

Molecular Characterization, Antibiotic Resistance, and Biofilm Formation of Isolated from Commercial Broilers from Four Chinese Provinces.

() represents a significant etiological agent of colibacillosis in poultry, resulting in considerable economic losses for the global poultry sector. The present study aimed to determine molecular characterization, antibiotic resistance, and biofilm formation of strains isolated from diseased broilers from four provinces of China. A total of 200 tissue samples were collected from the intestine, liver, crop, heart, and spleen and processed for microbiological examination.