Isolation of dihydroagarofuran sesquiterpene from the fruits of Tripterygium hypoglaucum and evaluation of their anti-inflammatory activity.

Twelve previously undescribed dihydroagarofuran sesquiterpenes, hypogricins I-XII (1-12), were isolated from the fruits of Tripterygium hypoglaucum, along with 14 known dihydro-β-agarofuran-type sesquiterpenoids. The structural elucidation of these previously undescribed compounds was achieved through using comprehensive spectroscopic analysis, single-crystal X-ray diffraction studies, and electronic circular dichroism (ECD) calculations. All the compounds were evaluated for their effects on HaCaT cell viability and their potential to inhibit tumor necrosis factor α (TNF-α)- and interleukin 17A (IL-17A)-induced inflammation.

Triterpenoids from the fruits of Aphanamixis polystachya and their inhibitory activities on nitric oxide production.

Nineteen triterpenoids, including five previously unknown (four triucallane-type derivatives and one highly oxidized A, B-seco limonoids), together with fourteen known triterpenoids, were isolated from the fruits of Aphanamixis polystachya. Their structures were elucidated by extensive spectroscopic analysis. All isolates were evaluated their anti-inflammatory activities.

Two new triterpenoids from the fruits of .

Two new triucallane triterpenoids, polystanin F () and polystanin G (), along with eight known compounds (-) were isolated from the fruits of . Their structures were established on the basis of extensive spectroscopic analysis. Moreover, eight compounds were evaluated for their cytotoxicity against three cancer cell lines (liver cancer RT112, colon cancer HCT-116 and breast cancer M231) using the MTT method.

MicroRNA‑138 promotes proliferation and suppresses mitochondrial depolarization in human pulmonary artery smooth muscle cells through targeting TASK‑1.

MicroRNA (miR)‑138 serves an important role in the proliferation, differentiation and apoptosis of human pulmonary artery smooth muscle cells (HPASMCs), indi-cating the involvement of miR‑138 in the development and progression of pulmonary artery hypertension (PAH). Potassium channel subfamily K member 3 (TASK‑1), a two‑pore domain K+ channel, is expressed in HPASMCs and is associated with hypoxic PAH. However, whether miR‑138 mediates PAH through targeting TASK‑1 is not known.

Synthesis and Scanning Tunneling Microscopy Observation of 1,3,5-Triazine Bearing Azo-Carboxylate.

A new compound (2,4,6-tris-(3,5-di-methyl formate-4′-hydroxy azobenzene)-1,3,5-triazine,TDHAT) has been synthesized and the scanning tunneling microscopy (STM) is utilized to clarify the geometrical configuration on the highly oriented pyrolytic graphite (HOPG) surface. The star-shaped molecule self-assembles into uniform and regular triangular petal structure at liquid–solid interface, and high-resolution images has been obtained, which implied a high stability of this two dimensional configuration. The distance between the scattered bright spot and the center of the petal is measured to be about 1.