Ultrasound-triggered injectable piezoelectric nanocomposite hyaluronic acid-based hydrogel for modulating inflammation and chondrogenesis in osteoarthritis treatment.

Osteoarthritis (OA), a common chronic joint disorder, is characterized by cartilage degeneration and inflammation. Electrical stimulation has shown promise as a treatment modality for OA, providing pain relief and fostering cartilage regeneration. However, its clinical application still remains limited.

Analysis and exploration of the association between serum tumor marker status and clinical pathological features, as well as efficacy, in colorectal cancer.

Colorectal cancer (CRC) remains a major global health challenge, necessitating improved prognostic and predictive tools. The aim of the present study was to investigate the associations between elevated serum tumor markers (TMs) and clinicopathological features in patients with colorectal cancer, to evaluate their prognostic ability in advanced-stage disease cases and to identify patients most likely to respond to treatment. This retrospective study analyzed data from 293 patients treated for colorectal adenocarcinoma between January 1, 2020, and June 30, 2023.

Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia.

Positive symptoms are a prominent feature of schizophrenia. Despite antipsychotic treatment, ~30% of patients develop refractory positive symptoms (RPSs). Current research fails to elucidate the potential neurophysiological mechanisms underlying RPSs, thereby hindering the development of additional treatments.

Sex differences in event-related potentials and their clinical predictive value in first-episode antipsychotic-naïve schizophrenia.

This study explored sex differences in cognitive impairments in first-episode antipsychotic-naive schizophrenia (FEAN-SZ) patients using event-related potentials. A total of 321 FEAN-SZ patients and 146 healthy controls (HCs) were enrolled to compare sex differences in the P300 (P3) components elicited by the auditory Oddball paradigm. The Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Scale (HAMD), and Hamilton Anxiety Scale (HAMA) were used to assess the clinical symptoms.

Black Phosphorus-Loaded Gelatin Methacryloyl Hydrogels Enhance Angiogenesis via Activation of the PEAK1-MAPK Pathway.

Repair and regeneration of oral and maxillofacial tissue defects remain significant challenges, mainly due to the limitations of existing treatment approaches. Conventional methods such as transplantation, tissue scaffolds, growth factors, and stem cell therapies often face obstacles, including donor shortages, insufficient vascularization, and safety concerns. There is an urgent need for innovative therapeutic strategies to effectively promote vascular regeneration while minimizing complications.

Immunomodulatory Effects and Mechanisms of Two-Dimensional Black Phosphorus on Macrophage Polarization and Bone Regeneration.

The repair of bone defects poses a significant challenge within the realm of clinical medicine. However, with the advent of various emerging biotechnologies, bone tissue engineering (BTE) has emerged as a promising discipline that offers innovative therapeutic strategies to address bone defects. Among the novel biomaterials being explored, two-dimensional (2D) black phosphorus (BP) has attracted considerable attention due to its advantageous properties, which include antimicrobial activity, drug delivery capabilities, and effective photothermal conversion.

Gut microbiota and other factors associated with increased T cell regulation in HIV-exposed uninfected infants.

Introduction: Infants exposed to HIV and uninfected (HEUs) are at higher risk of infectious morbidity than HIV-unexposed uninfected infants (HUUs). Multiple immune defects of unknown origin were observed in HEUs. We hypothesized that HEUs have more regulatory and inhibitory checkpoint-expressing T cells (Treg, Tici) than HUUs, which may dampen their immune defenses against pathogens.

Synergistic metabolic modulation of fibroblast-like synoviocytes targeted dual prodrug nanoparticles to mitigate rheumatoid arthritis.

Elevated glucose metabolism is a prominent characteristic of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). However, the efficacy of inhibiting a single target of glucose metabolism in FLS using small molecular inhibitors is limited for RA treatment. Herein, the synergistic inhibition of FLS' survival, proliferation, and activation by combining two glucose metabolism inhibitors, diclofenac (DC) and lonidamine (LND) was first verified.

Neurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study.

Alterations in the temporal characteristics of EEG microstates in patients with schizophrenia (SCZ) have been repeatedly found in previous studies. Nevertheless, altered temporal characteristics of EEG microstates in auditory verbal hallucinations (AVHs) SCZ are still unknown. This study aimed to investigate whether SCZ patients with sAVHs exhibit abnormal EEG microstates.

Duration of untreated psychosis and cognitive function in first-episode antipsychotic-naïve schizophrenia: Evidence from auditory P300.

Objective: The relationship between the duration of untreated psychosis (DUP) and cognitive function in schizophrenia (SZ) patients remains debated, with no empirical evidence from event-related potential (ERP) studies supporting their association. This study aims to investigate the relationship between DUP and cognitive functions, as well as psychiatric symptoms, in first-episode antipsychotic-naïve SZ (FEAN-SZ) patients using ERP.

Methods: The study included 321 Chinese FEAN-SZ patients and 146 healthy controls.

Comprehensive sinus contour classification and its characteristics from radiographic examination: a cross-sectional study.

Objective: The aim of this study was to propose a comprehensive maxillary sinus (MS) contour classification system based on the evaluation of anatomical characteristics from cone beam computed tomography (CBCT) examination and investigate the relationship between sinus contours and sinus floor elevation (SFE).

Methods: A total of 283 CBCT scans from patients who had single tooth loss in the posterior maxilla and underwent SFE were analyzed. The MS was classified at each tooth position.

Detection of viral RNA and DNA and immune response following administration of live attenuated measles and varicella vaccines in children with chronic liver disease.

Infections preventable by live virus vaccines are surging in the setting of decreased herd immunity. Many children with chronic liver diseases (CLDs) are unimmunized and at increased risk for infection due to guidelines recommending against live vaccines within 4 weeks pretransplant. This prospective study of 21 children with CLD and 13 healthy controls defined the timing of measles virus and varicella-zoster virus (VZV) RNA- and DNA-emia following vaccination and compared immune responses to measles and varicella vaccines in both groups.

The quality of life after keratinized mucosa augmentation around dental implants using xenogenic collagen matrix with or without stent.

Background: The substitution of missing teeth with implants is a dependable and anticipated therapeutic approach. Despite numerous studies affirming long-term success rates, there exists a spectrum of potential biological and aesthetic complications.

Objective: The primary objective of this study was to assess patient responses subsequent to surgical interventions, with a specific emphasis on the utilization of xenogenic collagen matrix (XCM), both with and without the application of a stent secured over healing abutments, in the context of keratinized gingival mucosa augmentation.

Gut Microbiota and Other Factors Associated With Increased Regulatory T Cells in Hiv-exposed Uninfected Infants.

HIV-exposed uninfected infants (HEU) have higher infectious morbidity than HIV-unexposed infants (HUU). HEU have multiple immune defects of unknown origin. We hypothesized that HEU have higher regulatory T cells (Treg) than HUU, which may dampen their immune defenses against pathogens.

40-Hz auditory steady-state response deficits are correlated with the severity of persistent auditory verbal hallucination in patients with schizophrenia.

Background: Abnormal 40 Hz auditory steady-state response (ASSR) has been observed in some psychiatric disorders. Nevertheless, the role of 40 Hz ASSR in persistent auditory verbal hallucinations (pAVHs) schizophrenia (SCZ) is still unknown. This study aims to investigate whether the 40 Hz ASSR impairment is related to pAVHs and can detect pAVHs severity.

The transalveolar approach with the small segmentation method for inclined maxillary sinus floor elevation: A retrospective study.

Objective: To evaluate the clinical outcome of the transalveolar approach with the small segmentation method for inclined maxillary sinus floor elevation.

Methods: Sixty-one patients with an inclined maxillary sinus floor (tilt angle ≥ 10°) and insufficient residual bone height in the posterior maxilla were included and grouped according to the tilt angle of the sinus floor, with group A having patients with the tilt angle ≥ 10° and ≤ 30° and group B having patients with the tilt angle > 30°. After completing sinus membrane elevation and bone augmentation using bone substitute materials, the implants were inserted at the same appointment, and the restoration was completed after 5-6 months of osseointegration.

Cytomegalovirus in biliary atresia is associated with increased pretransplant death, but not decreased native liver survival.

Background: Biliary atresia (BA) is likely caused by a common phenotypic response to various triggers; one proposed trigger, cytomegalovirus (CMV), may lead to worse outcomes. The aim of this study was to determine the severity of disease and pretransplant outcomes of infants with BA, who have evidence of CMV (CMV+) at diagnosis compared with CMV-negative (CMV-) infants.

Methods: The study used data and biospecimens from the Childhood Liver Disease Research Network PROBE study of cholestatic infants.

One-Abutment at One-Time in Posterior Edentulism: A Systematic Review and Meta-Analysis.

Objective: The objective of this systematic review and meta-analysis was to investigate the clinical significance of one-abutment at one-time protocol in healed posterior edentulism.

Methods: An online search was undertaken in November 2022, which included PubMed, Cochrane Library, Wiley Online Library, and Google Scholar in addition to manual searching. The Cochrane Collaboration tool was performed to assess the quality of selected articles.

Cytotoxicity Induced by Black Phosphorus Nanosheets in Vascular Endothelial Cells via Oxidative Stress and Apoptosis Activation.

Black phosphorus (BP), an emerging two-dimensional material with unique optical, thermoelectric, and mechanical properties, has been proposed as bioactive material for tissue engineering. However, its toxic effects on physiological systems remain obscure. The present study investigated the cytotoxicity of BP to vascular endothelial cells.

Response of Human Gingival Fibroblasts and to UVC-Activated Titanium Surfaces.

Ultraviolet (UV) photofunctionalization has been demonstrated to synergistically improve the osteoblast response and reduce biofilm formation on titanium (Ti) surfaces. However, it remains obscure how photofunctionalization affects soft tissue integration and microbial adhesion on the transmucosal part of a dental implant. This study aimed to investigate the effect of UVC (100-280 nm) pretreatment on the response of human gingival fibroblasts (HGFs) and () to Ti-based implant surfaces.

Preoperative online intervention to dental anxiety in patients with transcrestal sinus floor elevation.

Objective: Dental anxiety (DA) is a frequent and widespread phenomenon worldwide. There are few studies that have discussed the preoperative intervention of dental anxiety. The aim of this study was to explore the clinical efficacy of an online intervention to improve understanding and reduce dental anxiety in patients with transcrestal sinus floor elevation (TSFE) and to explore the correlation between patients' understanding and dental anxiety, pain perception, and satisfaction.

Apatite-forming ability of sandblasted and acid-etched titanium surfaces modified by ultraviolet irradiation: An in vitro study.

Introduction: Contamination of large grit sandblasting and acid-etching (SLA) with hydrocarbons make the surface hydrophobic and influence its bioactivity. Preservation in dHO (modified SLA, modSLA) and ultraviolet (UV) irradiation were proven to be effective in decreasing hydrocarbon contamination and keeping the SLA surface hydrophilic.

Aims: The aim of this study was to detect the in vitro bioactivity of SLA, modSLA and UV-SLA surfaces.

β-elemene inhibits non-small cell lung cancer cell migration and invasion by inactivating the FAK-Src pathway.

Despite sustained effort, the prognosis of lung cancer remains poor and the therapeutic responses are limited. Cell movement ability is a prerequisite for lung cancer metastasis, which involves focal adhesion kinase (FAK)-mediated cell migration and invasion via complex formation with Src. Hence, FAK-Src signaling might be an effective target for anti-cancer treatment.

Retraction of "Biological Effects of Titanium Surface Charge with a Focus on Protein Adsorption".

[This retracts the article DOI: 10.1021/acsomega.0c02518.