Analyses of the mechanism and therapeutic targets of senescence related genes in ischemic stroke with multi-omics approach.

Ischemic stroke (IS) affects 11 million people annually, posing substantial clinical and economic burdens. Current therapies remain limited by time sensitivity and variable efficacy, necessitating novel biomarkers. We developed a multi-omics framework to investigate senescence-associated gene regulation in IS.

Comparative efficacy of drug-eluting stents vs. bare-metal stents in symptomatic vertebral artery stenosis: A prospective single-center study.

Objective: To explore the safety, efficacy of drug-eluting stents and bare-metal stents in the treatment of vertebral artery stenosis, and the influencing factors of in-stent restenosis.

Methods: From June 2022 to October 2023, 129 patients undergoing vertebral artery stent implantation in the Department of Neurosurgery of the First Hospital of Hebei Medical University were randomly divided into the drug-eluting stent group and the bare-metal stent group using a randomized controlled method and followed up. The clinical data of the patients were recorded and divided into the stenosis group and the non-stenosis group according to whether in-stent restenosis occurred after surgery.

ELK3 expression as a prognostic marker in patients with glioma.

Objective: This study aims to elucidate the expression and clinical relevance of ELK3 in gliomas and to predict its biological functions using comprehensive database analyses.

Methods: We utilized data from glioma patients in the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) to investigate ELK3 expression across different tumor grades. The impact of ELK3 expression on patient survival was evaluated using Kaplan-Meier survival analysis, and both univariate and multivariate Cox regression analyses.

Efficacy of Neuroendoscopy Surgery Combined With Postoperative Lokomat Rehabilitation Training in Patients With Hypertensive Intracerebral Hemorrhage.

Objective: To explore the effects of neuroendoscopy surgery combined with postoperative Lokomat rehabilitation training on patients with hypertensive cerebral hemorrhage.

Methods: A total of 88 patients with hypertensive cerebral hemorrhage who underwent surgical treatment in our hospital were retrospectively analyzed. They were divided into a study group and a conventional group with 44 patients in each group.

Analysis of Effect of Minimally Invasive Fourth-ventricle Hematoma Removal for Patients with Intraventricular Hemorrhage Casting and Influence of Feedback Early Rehabilitation on Postoperative Neurological Function.

Purpose: To investigate the therapy effect of minimally invasive fourth-ventricle hematoma removal (MIFHR) for patients with intraventricular hemorrhage (IVH) casting and the influence of feedback early rehabilitation on post-operative neurological function.

Methods: Eighty patients with IVH casting were enrolled from January 2019 to December 2020 in this retrospective study. Forty patients receiving MIFHR with feedback early rehabilitation were divided into the observational group, while the others receiving bilateral external ventricular drainage with traditional rehabilitation were divided into the control group.

Combined Effect of Early Physical Exercise and Stereotactic Hematoma Evacuation in Patients with Cerebral Hemorrhage Undergoing Hemodialysis.

Objective: This study investigated the combined effect of stereotactic hematoma evacuation and early postoperative physical function exercise in hemodialysis patients with cerebral hemorrhage.

Methods: A retrospective study was conducted, including a total of 78 hemodialysis patients with cerebral hemorrhage treated at our hospital between January 2021 and June 2022. The patients were equally allocated to two groups based on different postoperative rehabilitation methods.

Analysis of the curative effect and influencing factors of stereotactic aspiration in the treatment of primary brainstem haemorrhage.

Primary brainstem haemorrhage (PBH) is characterized by acute onset, rapid deterioration, many complications, and poor prognosis. Its treatment has been controversial. This study aimed to explore the clinical risk factors of postoperative survival and neurological function recovery of stereotactic aspiration in the treatment of PBH.

The Prognosis Factors for Endovascular Coiling of Aneurysm in Patients With Ruptured Intracranial Aneurysm.

Background: The spontaneous subarachnoid hemorrhage caused by aneurysm rupture often leads to a variety of complications. Endovascular coiling is effective in the treatment of ruptured intracranial aneurysm.

Aim: The authors aim to evaluate the risk factors affecting the prognosis of ruptured intracranial aneurysm in patients who received endovascular coiling treatment successfully.