Publications by authors named "Seung-Taek Lim"

Background: This study aimed to determine the risk of anterior cruciate ligament (ACL) injury in female college students according to sleep quality and use this information to prevent injury.

Methods: Twenty-six female university students were recruited for the present study. Participants underwent assessments for sleep quality, landing error scoring system (LESS), and electromyographic (EMG) activity for imbalances by comparing the muscle activity of the left and right rectus femoris (RF-to-RF) and biceps femoris (BF-to-BF) muscles.

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Background/objectives: This study aims to investigate the relationship between sleep duration, physical activity, and nutritional intake of calories and vitamins to determine the interconnections among sleep, physical activity, and dietary habits.

Methods: Overall, 5491 participants (male = 2347, female = 3144) aged ≥ 18 years were recruited from the first survey of the 2023 9th Korea National Health and Nutrition Examination Survey (KNHANES). All participants were assessed for sleep duration, physical activity levels, and intake of vitamin D, carbohydrates, protein, and fat.

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: Modulating ethanol metabolism and attenuating alcohol-induced oxidative stress are promising therapeutic strategies for reducing the severity of hangovers and alleviating their associated physiological burden. : A randomized, double-blind, placebo-controlled, crossover study was conducted to evaluate the effects of the probiotic strain VITA-PB2 on ethanol metabolism, oxidative stress, and hangover-related symptoms in 28 healthy adults. The participants consumed either VITA-PB2 or a placebo before standardized alcohol intake, with a 7-day washout period and subsequent crossover.

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Background: This study aimed to determine the physical activity level and protein intake of older people with sarcopenia and investigate the adequate protein intake of older people in Korea.

Methods: A total of 1215 older people were recruited from the ninth Korea National Health and Nutrition Examination Survey. Participants' physical activity, handgrip strength, appendicular skeletal muscle mass and food intake were assessed.

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Bcl-2, a key regulator of cellular apoptosis, is typically linked to adverse prognosis in solid tumors due to its inhibition of apoptotic cell death and promotion of cellular proliferation, leading to tumor progression. However, studies on Bcl-2 in breast cancer have shown inconsistent results, with some indicating favorable outcomes. This study aims to determine the subtype-specific role of Bcl-2 in breast cancer.

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Purpose: Tumor suppressor p53 (TP53) mutations are common in head and neck squamous cell carcinoma (HNSCC). We evaluated their clinical impact in patients treated with targeted agents or immunotherapy in the KCSG HN15-16 TRIUMPH trial.

Materials And Methods: We analyzed clinical characteristics and outcomes of patients with TP53 mutations in the TRIUMPH trial, a multicenter, biomarker-driven umbrella trial in Korea.

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: The 2015 American Thyroid Association guidelines recommend the maintenance of serum thyroid stimulating hormone (TSH) levels ≤2 mIU/L in patients with low-risk papillary thyroid carcinoma (PTC) who underwent lobectomy; however, the evidence is insufficient. We investigated the association between maintaining the TSH status at ≤2 mIU/L and tumor recurrence in patients with low-risk PTC who underwent lobectomy through a 5-year landmark analysis. : Between 2010 and 2016, 662 patients with low-risk PTC were included.

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The prognosis of early gastric cancer (EGC) patients is associated with lymph node metastasis (LNM). Considering the relatively high rate of LNM in T1b EGC patients, it is crucial to determine the factors associated with LNM. In this study, we constructed and validated predictive models based on machine learning (ML) algorithms for LNM in patients with T1b EGC.

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Background: This study aimed to elucidate the relationship between physical activity, body weight, liver function, and insomnia in Korean adults, thereby providing a foundation for health promotion strategies.

Methods: We recruited 11,645 adults (8,051 males and 3,594 females). Participants underwent assessments using the Korean version of the Insomnia Severity Index, measures of physical activity (PA), anthropometric data (body weight, height, body mass index [BMI], and waist circumference [WC]), and liver function (alanine aminotransferase, aspartate aminotransferase [AST], and gamma-glutamyl transferase).

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Introduction: Non-infectious erythema, or Red Breast Syndrome (RBS), has been observed on the skin where acellular dermal matrix was implanted, although the exact cause is yet to be determined.

Patients And Methods: A total of 214 female patients underwent breast-conserving surgery (BCS) and volume replacement using diced acellular dermal matrix (dADM) for breast cancer between December 2017 and December 2018. After collecting and evaluating relevant clinical data, inflammation markers, along with NK cell status presented by IFN-γ secretion assay, were measured using ELISA.

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Article Synopsis
  • The study analyzed 396 female patients with invasive breast cancer to explore the connection between peripheral NK cell activity and various clinical parameters related to the disease.
  • Measurements of NK cell activity were based on interferon-gamma (IFN-γ) secretion, which showed that lower levels of IFN-γ were associated with more advanced cancer stages and increased body mass index (BMI).
  • The results indicated a potential link between NK cell activity and inflammation markers, suggesting that NK cell function might provide insights into breast cancer progression and could help in assessing a patient's clinical status at diagnosis.
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  • CT-P6, a biosimilar for trastuzumab, is approved for treating HER2-positive early breast cancer, metastatic breast cancer, and metastatic gastric cancer.
  • A 1-year post-marketing surveillance study in South Korea evaluated its safety and effectiveness, involving 642 patients treated with CT-P6.
  • Results showed that while over half of the patients experienced adverse events, the majority did not indicate new safety concerns, and notable responses were observed in a significant portion of trastuzumab-naïve patients.
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  • This study explored how genetic changes in PI3KCA and cell cycle pathways affect the effectiveness of durvalumab in patients with head and neck squamous cell carcinoma who did not respond to prior platinum-based treatments.
  • Data was collected from a phase II trial involving 87 patients segmented into three groups based on their genetic alterations: PIK3CA changes (Group A), cell cycle alterations (Group B), and no significant genetic changes (Group C).
  • The results showed no significant differences in treatment outcomes between the groups, but lower neutrophil-lymphocyte and platelet-lymphocyte ratios were associated with better progression-free survival, suggesting these could be useful biomarkers for predicting treatment response.
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Background: Existing research on the association between cognitive function and physical activity in the older adults population with disabilities is limited. Additionally, there is a need to explore avenues for enhancing the longevity and quality of life among these individuals.

Objective: This study aimed to investigate the independent and joint associations between cognitive function and levels of physical activity in the older adults population with disabilities.

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Background: The aim of this study was to investigate the changes in isokinetic muscular performance among female adolescent elite handball athletes with the supplementation of Black Maca (BM).

Methods: Eight elite handball athletes were recruited for the present study. The intake capsules contained 2,500 mg of 100% concentrated BM extract and a placebo each, for 4 weeks.

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Background/aim: This study investigated the treatment patterns and prognosis of patients with metastatic or unresectable colorectal cancer (mCRC) treated with chemotherapy with targeting agents.

Patients And Methods: This longitudinal multicenter study included 963 patients with mCRC who were treated in Korea between 2016 and 2020. Treatment patterns and efficacy were compared according to the mutation status and clinical factors.

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Article Synopsis
  • - The study investigates how tumor vascularity, measured by Hounsfield units (HU) in contrast-enhanced CT scans, affects survival rates in different breast cancer subtypes, focusing specifically on early-stage cases.
  • - Analyzed data from 440 patients revealed that a higher tumor-to-aorta ratio (TAR) correlated with significantly worse recurrence-free and overall survival, particularly in patients with estrogen receptor-positive (ER-positive) and human epidermal growth factor receptor 2-negative (HER2-negative) breast cancer.
  • - The findings suggest TAR could serve as an effective biomarker for predicting patient outcomes in breast cancer, emphasizing its importance in understanding the relationship between cancer vascularity and survival rates.
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Aging is characterized by the gradual deterioration of function at the molecular, cellular, tissue, and organism levels in humans. The typical diseases caused by changes in body composition, as well as functional decline in the human body's organs due to aging include sarcopenia and metabolic disorders. The accumulation of dysfunctional aging β cells with age can cause decreased glucose tolerance and diabetes.

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