Correcting Sunken Eyelid by Orbital Fat Transposition During Subbrow Lift.

Background: The subbrow approach is reportedly more effective than upper blepharoplasty for improving lateral hooding. Additionally, it allows for the removal of thick periorbital fat while simultaneously tightening weakened and sagging orbicularis oculi muscles. This study introduces a method for repositioning and redistributing the medial fat pad to the central area, restoring fullness in the central area, and improving medial upper eyelid bulging.

GULP1 Regulates Tendon Cell Proliferation and Maturation Essential for Motor Coordination in Mice.

Aim: Tendons are fibrous tissues connecting muscles to bones, providing joint stability and enabling movement. Adaptor proteins regulate cellular processes essential for maintaining tendon function. Phosphotyrosine-binding domain-containing engulfment adaptor protein 1 (GULP1) participates in multiple cellular activities; however, its specific role in tendons remains unclear.

Early Grafting Using AlloDerm to Lengthen the Levator Aponeurosis and Correct Upper Eyelid Retraction Caused by Cosmetic Blepharoplasty.

Summary: Upper eyelid retraction often results from overcorrection of the levator palpebrae muscle during upper eyelid surgery. In such patients, the time between wound healing and reoperation may be prolonged and could result in symptoms, including dry eye. Therefore, the correction surgery-in which the levator aponeurosis that was shortened by cosmetic blepharoplasty is lengthened-should be performed as early as possible for better patient satisfaction and surgical outcomes.

The comparative study of Stretta radiofrequency and anti-reflux mucosectomy in the management of intractable gastroesophageal reflux disease: a single-center retrospective study from Korea.

Background/aims: Chronic gastroesophageal reflux disease (GERD) requires symptom relief and treatment of associated conditions. In this study, we aimed to compare anti-reflux mucosectomy (ARMS) and Stretta radiofrequency (SRF) for treating patients with chronic GERD who are unresponsive to proton pump inhibitors (PPIs) and to identify the indications for each procedure.

Methods: Data of patients who underwent ARMS or SRF between March 2021 and April 2023 were analyzed.

Neuroprotective Activities of Sertraline, Tiagabine, and Bicifadine with Autophagy-Inducing Potentials in a 6-Hydroxidopamine-Treated Parkinson's Disease Cell Model.

Parkinson's disease (PD) is one of neurodegenerative diseases characterized by the progressive loss of dopaminergic neurons in the substantia nigra. The development of a neuroprotective therapy is crucial for mitigating features and progression of PD. Since autophagy induction has recently emerged as a promising neuroprotective strategy, this study aimed to identify autophagy-inducing compounds and evaluate their neuroprotective activity.

Comparing the feasibility, safety, and efficacy of Stretta radiofrequency and antireflux ablation therapy for treating patients with refractory gastroesophageal reflux disease: a retrospective, single-center cohort study.

Background And Aims: This study compared Stretta radiofrequency (SRF) and antireflux ablation therapy (ARAT) using argon plasma coagulation for the treatment of refractory chronic GERD.

Methods: The primary focus of this single-center retrospective cohort study involving 329 patients was the change in GERD questionnaire (GERDQ) scores. Secondary measures included Los Angeles (LA) classification, Hill's flap valve grade, proton pump inhibitor (PPI) discontinuation rate, Barrett's esophagus resolution rate, and incidence of adverse events.

Predictors of optimal angiographic lesion outcomes in drug-coated balloon treatment for de novo coronary artery disease.

Drug-coated balloon (DCB) treatment is an emerging strategy for de novo coronary artery disease (CAD), but procedural optimization remains uncertain. This study analyzed 317 patients who underwent DCB-based intervention for de novo CAD and angiographic follow-up: SR (successful, stent-like result: diameter stenosis < 20% at follow-up angiography, n = 84, 93 lesions) and Non-SR (n = 224, 358 lesions) groups. Baseline clinical and lesion characteristics were similar, except that SR lesions had larger diameter.

sp. nov., sp. nov., and Coprophilous Fungi Isolated from Horse Dung in Seopjikoji, Jeju Island in the Republic of Korea.

The genus is widely distributed and includes species with ecological and biotechnological importance. In this study, morphological and phylogenetic analyses of the ITS and LSU rDNA sequences revealed two novel species, sp. nov.

Sarcopenia: how to determine and manage.

Background: Understanding sarcopenia is becoming increasingly important as society ages. This comprehensive review covers the definition, epidemiology, causes, pathogenesis, diagnosis, prevention, management, and future directions for the management of sarcopenia, and the major issues related to sarcopenia in the knee joint.

Main Text: Sarcopenia, a condition related to aging, is characterized by decreased muscle mass and strength, which significantly affects physical function.

sp. nov., sp. nov., and sp. nov. (Nectriaceae), Novel Fungi Isolated from Soil in Jeju Island and Upo Wetland in the Republic of Korea.

In this study, three novel fungal species belonging to the Nectriaceae family, sp. nov., sp.

Association of radiographic structure deformity phenotypes of knee OA to clinical symptoms and risk for progression: Proposing a modification of Kellgren-Lawrence grade - Data from the Osteoarthritis Initiative and the MOST study.

Objective: This study aims to define Kellgren-Lawrence grade (KLG) using OARSI grade and stratify radiographic knee osteoarthritis (KOA) into distinct phenotypes based on radiographic structure changes and compare clinical symptoms and disease progression.

Design: We used radiographic grading data provided by the OAI and MOST study. Decision tree was used to (1) Find OARSI grade criteria for each KLG and (2) Phenotype early osteoarthritic knees (=KLG1, 2) by the radiographic structure changes.

Antimicrobial and Antibiofilm Activities of Urinary Catheter Incorporated with ZnO-Carbon Nanotube.

Urinary tract infections are among the most common nosocomial infections, with the majority being catheter-associated urinary tract infections (CAUTIs). This study demonstrated that an antimicrobial and antibiofilm urinary catheter containing zinc oxide-carbon nanotubes (ZnO-CNT) can inhibit CAUTIs in patients. ZnO-CNT polymers were synthesized by mixing ZnO and CNT using a high-shear mixer, and the synthesized ZnO-CNT polymers were incorporated into a silicone matrix to produce a ZnO-CNT urinary catheter.

Evaluation of a Novel Method for Temporary Eyebrow Lifting Using Polydioxanone Threads: Preliminary Findings.

Aging affects the face and eyebrow areas, with various resultant procedures for lifting the eyebrows. Recently, thread lifting using absorbable threads has become increasingly popular, with the advantages of a faster recovery and no visible scars, when compared with conventional facial rhytidectomy. Furthermore, polydioxanone (PDO) thread lifting is a favorable surgical method that has been used for eyebrow lifting.

Inhibitory effects of Colocasia antiquorum var. esculenta varnish on inflammation and alveolar bone loss in a rat ligature-induced periodontitis model.

We aimed to evaluate whether Colocasia antiquorum var. esculenta (CA) mixed with experimental varnish inhibits inflammation and alveolar bone loss in a rat ligature-induced periodontitis model. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) were tested and cell viability of CA were also evaluated.

Prognostic Impact of Multiple Synchronous T1 Breast Cancer.

: The reported incidence of multiple breast cancers varies widely, ranging from 6 to 60%, depending on the definitions used and methods of detection. With advancements in preoperative imaging techniques, such as magnetic resonance imaging, the detection of multiple breast cancers has improved. However, the clinical significance of multiple breast cancers remains controversial, with conflicting results regarding their impact on prognosis.

Oval Tunnel Shows Better Rotational Stability Than Round Tunnel in Anatomical Single-Bundle Anterior Cruciate Ligament Reconstruction: Biomechanical Study in a Porcine Model.

Background: To compare knee laxity between the conventional round tunnel and oval tunnel techniques in primary anterior cruciate ligament (ACL) reconstruction in a porcine knee model.

Methods: Twenty porcine knees were used for evaluating laxity in terms of anterior translation and anterolateral rotation. The study determined porcine knee kinematics on the Instron instruments under simulated Lachman (89 N anterior tibial load) at 15°, 30°, and 60° of flexion and a simulated pivot shift test (89 N anterior tibial load, 10 Nm valgus, and 4 Nm internal tibial torque) at 30° of flexion.

Comparative associations of non-alcoholic fatty liver disease and metabolic dysfunction-associated steatotic liver disease with risk of incident chronic kidney disease: a cohort study.

Background: We examined the comparative associations between non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated steatotic liver disease (MASLD) definitions with risk of developing chronic kidney disease (CKD) and abnormal albuminuria.

Methods: We conducted a cohort study of 214,145 Korean adults with normal kidney function at baseline who underwent liver ultrasonography. Participants were further subdivided into no steatotic liver disease (no-SLD), NAFLD-only, MASLD-only, both NAFLD and MASLD, and SLD not categorized as NAFLD or MASLD groups.

Primary Total Knee Arthroplasty for Treating Osteoarthritic Knees with Neglected Patellar Dislocation.

: Neglected patellar dislocation in the presence of end-stage osteoarthritis (OA) is a rare condition characterized by the patella remaining laterally dislocated without reduction. Due to the scarcity of reported cases, the optimal management approach is still uncertain. However, primary total knee arthroplasty (TKA) can serve as an effective treatment option.

Comparative clinical feasibility of antireflux mucosectomy and antireflux mucosal ablation in the management of gastroesophageal reflux disease: Retrospective cohort study.

Objectives: No definitive treatment has been established for refractory gastroesophageal reflux disease (GERD). Antireflux mucosectomy (ARMS) and antireflux mucosal ablation (ARMA) using argon plasma coagulation are promising methods. However, no study has compared these two.

Anatomical Reference of the Femur after Distal Resection Is Reliable for Rotational Alignment in Total Knee Arthroplasty.

The rotational alignment of the femoral component in total knee arthroplasty (TKA) is considered an important factor, but it is still difficult to assess intraoperatively. This study was conducted to identify anatomical parameters for femoral rotational alignment. A total of 204 patients who underwent primary TKA between 2015 and 2019 were enrolled.

Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation.

Inhibiting the functional role of negative regulators in immune cells is an effective approach for developing immunotherapies. The serine/threonine kinase hematopoietic progenitor kinase 1 (HPK1) involved in the T-cell receptor signaling pathway attenuates T-cell activation by inducing the degradation of SLP-76 through its phosphorylation at Ser-376, reducing the immune response. Interestingly, several studies have shown that the genetic ablation or pharmacological inhibition of HPK1 kinase activity improves the immune response to cancers by enhancing T-cell activation and cytokine production; therefore, HPK1 could be a promising druggable target for T-cell-based cancer immunotherapy.