Seamless finer-resolution soil moisture from the synergistic merging of the FengYun-3 satellite series.

In the last years, more satellites with microwave imagers have been launched, making more observations available to obtain soil moisture estimates globally. China's endeavour has resulted in the launch of the FengYun (FY) passive microwave observations (FY-3B, C, D) capable of filling in global soil moisture data gaps. In this study, we develop a merged soil moisture dataset at a spatial resolution of 0.

Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication.

The mechanistic link between the complex mutational landscape of de novo methyltransferase DNMT3A and the pathology of acute myeloid leukemia (AML) has not been clearly elucidated so far. Motivated by a recent discovery of the significance of DNMT3A-destabilizing mutations (DNMT3A) in AML, we here investigate the common characteristics of DNMT3A AML methylomes through computational analyses. We present that methylomes of DNMT3A AMLs are considerably different from those of DNMT3A AMLs in that they exhibit increased intratumor DNA methylation heterogeneity in bivalent chromatin domains.

Remote sensing of water colour in small southeastern Australian waterbodies.

The colour of a waterbody may be indicative of the water quality or environmental change. Monitoring water colour can therefore be an important proxy for various waterbody processes. To this aim, satellites are increasingly being used as viable alternatives to field measurements.

Systematic analysis of Mendelian disease-associated gene variants reveals new classes of cancer-predisposing genes.

Background: Despite the acceleration of somatic driver gene discovery facilitated by recent large-scale tumor sequencing data, the contribution of inherited variants remains largely unexplored, primarily focusing on previously known cancer predisposition genes (CPGs) due to the low statistical power associated with detecting rare pathogenic variant-phenotype associations.

Methods: Here, we introduce a generalized log-regression model to measure the excess of pathogenic variants within genes in cancer patients compared to control samples. It aims to measure gene-level cancer risk enrichment by collapsing rare pathogenic variants after controlling the population differences across samples.

Predicting cyanobacteria occurrence using climatological and environmental controls.

The occurrence of algal bloom results in deterioration of water quality, undesirable sights, tastes and odors, and the possibility of infections to humans and fatalities to livestock, wildlife and pets. Earlier studies have identified a range of factors including water temperature, flow, and nutrient concentrations that could affect cyanobacterial proliferation. Lack of enough data, independence in data across multiple sampling time steps, as well as the presence of more than one causative factors, each with different levels of influence on the response, has resulted in limited progress in the development of generalized prediction frameworks for cyanobacteria.

NCAM140 and pCREB Expression after Tianeptine Treatment of SH-SY5Y Cells.

Objective: Antidepressants Modulate Neuronal Plasticity. Tianeptine, An Atypical Antidepressant, Might Be Involved In The Restoration Of Neuronal Plasticity; It Primarily Enhances The Synaptic Reuptake Of Serotonin. Ncam140 Is Involved In Neuronal Development Processes, Synaptogenesis And Synaptic Plasticity.

Erythrocyte n-3 polyunsaturated fatty acid and seafood intake decrease the risk of depression: case-control study in Korea.

Background/aims: Low intake or tissue levels of n-3 polyunsaturated fatty acids (PUFA) have been associated with an increased risk of depression, but some studies do not support the association. The purpose of the present study was to evaluate the hypothesis that erythrocyte levels of n-3 PUFA and intake of seafood are negatively associated with the risk of depression in Koreans.

Methods: We investigated 80 patients diagnosed with a score ≥25 on the Center for Epidemiological Studies Depression Scale, Korean version, and confirmed by a psychiatrist.

N-3 polyunsaturated fatty acid consumption produces neurobiological effects associated with prevention of depression in rats after the forced swimming test.

Epidemiological data and clinical trials suggest that n-3 polyunsaturated fatty acids (PUFA) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have preventive and therapeutic effects on depression; however, the underlying mechanism remains elusive. The present study aimed to examine the behavioral effects and antidepressant mechanism of n-3 PUFA using a forced swimming test. Eleven-week-old male Sprague-Dawley rats were fed an American Institute of Nutrition-93M diet containing 0%, 0.

Fluoxetine-induced up-regulation of 14-3-3zeta and tryptophan hydroxylase levels in RBL-2H3 cells.

The primary mechanisms of antidepressants are based on the monoamine depletion hypothesis. However, we do not yet know the full cascade of mechanisms responsible for the therapeutic effect of antidepressants. To identify the genes involved in the therapeutic mechanism of the selective serotonin reuptake inhibitor, fluoxetine, we used a cDNA microarray analysis with RBL-2H3 cells.