Real-world data on trastuzumab emtansine (TDM1) efficacy and safety: Results of a single-centre retrospective study of HER2-positive metastatic breast cancer patients.

HER2-positive metastatic breast cancer (MBC) represents a challenging subtype of breast cancer, characterized by aggressive disease and poor clinical outcomes. Trastuzumab emtansine (TDM1), an antibody-drug conjugate combining trastuzumab and emtansine, has demonstrated efficacy in clinical trials as a second-line treatment for patients progressing after prior therapies. This study aims to provide real-world evidence on the efficacy and safety of TDM1 in HER2-positive MBC patients.

Triple Oral Metronomic Chemotherapy Versus Chemotherapy of Physician Discretion After Failure of Platinum-Based Therapy in Advanced Head and Neck Cancer: A Phase III Randomized Study (METRO-CHASE Study).

Purpose: Platinum-refractory advanced head and neck squamous cell carcinoma (HNSCC) has poor outcomes and limited treatment options, especially in resource-constrained settings. Triple oral metronomic chemotherapy (OMCT), involving low-dose continuous administration of chemotherapeutic agents, has shown promise in phase II studies but lacks evidence from randomized controlled trials. This study evaluated whether triple OMCT improves overall survival (OS) compared with chemotherapy of physician discretion (CPD).

Deep transfer learning hybrid techniques for precision in breast cancer tumor histopathology classification.

The breast cancer is one of the most prevalent causes of cancer-related death globally. Preliminary diagnosis of breast cancer increases the patient's chances of survival. Breast cancer classification is a challenging problem due to dense tissue structures, subtle variations, cellular heterogeneity, artifacts, and variability.

NIRADS-based case assessment of post-treatment head and neck cancer and its clinical correlation: A validation study.

Introduction: The neck imaging reporting and data system (NIRADS) lexicon is aimed at surveillance of head and neck cancer during post-treatment follow-up using either a CECT or PET-CT scan. These recommendations standardize management, reduce interobserver variability, and standardizes scientific communication.

Objectives: The primary aim of this study was to validate the correlation between the NI-RADS category and disease status on clinical follow-up and histopathological analysis.

Unravelling Eribulin's role in metastatic breast cancer: evaluating benefits for both triple negative and non-triple negative patients in real-world scenarios in resource-constrained settings.

Background: Metastatic breast cancer (MBC) patients have numerous options for treatment. However, it is essential to consider treatments with favorable toxicity profiles and convenient modes of administration. Eribulin has shown effectiveness in aggressive MBC, but there is a lack of sufficient real-world data specific to Indian patients.

Traumatic subcutaneous emphysema following blood donation: A case report.

Background: Subcutaneous emphysema is a condition where air becomes trapped under the skin, typically resulting from surgery or skin trauma. It is mostly localized and its occurrence in blood donors is exceedingly rare. Phlebotomy poses minimal risk of subcutaneous emphysema, but procedural errors may lead to such complications.

Photoluminescence study in Ho/Tm/Yb/Li:Gd(MoO) nanophosphors for near white light emitting diode and security ink applications.

Ho/Yb/Tm/Li:Gd(MoO) nanophosphors successfully synthesised via solid state reaction method have been structurally and optically characterised. Under 980 nm diode laser excitation the nanophosphors emit intense blue, green, red and NIR emissions peaking at ∼476 nm, ∼543 nm, ∼646 nm and ∼798 nm corresponding to the G → H (Tm), F, S → I (Ho), F  → I (Ho) and H → H (Tm) transitions respectively. The upconversion emission intensity enhancement in the Ho-Yb-Tm-Li:Gd(MoO) nanophosphors for the green band is found to be ∼367, ∼50 and ∼9 times compared to the singly Ho doped, Ho-Yb co-doped and Ho-Yb-Tm tri-doped Gd(MoO) nanophosphors.

Failed Back Surgery Syndrome: Evaluation with Magnetic Resonance Imaging.

Introduction: Failed Back Surgery Syndrome (FBSS) is a generalized term used to describe varied spinal symptoms of patients who have had unsuccessful results after spinal surgery. The treatment of FBSS is challenging and varies from conservative management to reoperation. Imaging plays a crucial role in identifying the cause and helps to guide the appropriate therapy.

Inferior Vena Cava Agenesis: A Rare Cause of Pelvic Congestion Syndrome.

Complete absence of Inferior Vena Cava (IVC) is a rare anomaly with a reported incidence of 0.0005% to 1%. This is often asymptomatic with incidental detection during cross-sectional imaging.

Thoracic Sarcoidosis: Imaging with High Resolution Computed Tomography.

Introduction: Sarcoidosis is a disease of unknown aetiology that primarily affects the lungs. Clinical and radiological findings with demonstration of non caseating granulomas on pathology is utilised for diagnosing the disease.

Aim: To assess and evaluate the features of thoracic sarcoidosis on High Resolution Computed Tomography (HRCT) chest.

Sphincter saving anorectoplasty (SSARP) for the reconstruction of Anorectal malformations.

Background: This report describes a new technique of sphincter saving anorectoplasty (SSARP) for the repair of anorectal malformations (ARM).

Methods: Twenty six males with high ARM were treated with SSARP. Preoperative localization of the center of the muscle complex is facilitated using real time sonography and computed tomography.

One-stage correction of recto-vestibular fistula by trans-fistula anorectoplasty (TFARP).

Background: The present article details a new technique for the repair of recto-vestibular fistula.

Materials And Methods: Twenty-five patients with recto-vestibular fistula, between 13 days and 4 years of age underwent surgical correction by trans-fistula ano-recto-plasty (TFARP). The technique, described in detail, involves mobilization of the fistula and the rectum through the fistula and creation of a new anus in the anatomically normal site by preserving both the perineal skin bridge (skin between the neo-anus and the posterior fourchette) and the levator muscle.

Complex urethral disruptions: in pursuit of a successful reconstruction.

Objectives: We analyzed the methods and outcomes of urethroplasty in men with complex urethral disruptions.

Methods: The medical records of 40 men with complex urethral disruptions were analyzed. Surgical methods were individualized according to stricture location, severity and length of the stricture, bladder neck characteristics and presence of complicating factors.

Central neural blocks: a quality assessment of anaesthesia in gynaecological surgeries.

Quality of anaesthetic care can be improved only after identifying the factors contributing to patients' discomforts and dissatisfaction. The purpose of this prospective observational study was to assess the quality of central neural blocks in terms of physiological alterations and undesired events and to find out modifiable factors associated with patients' discomforts and dissatisfaction. Total 204 female patients (ASA I and II) undergoing gynaecological surgeries received either of the subarachnoid block (SAB), combined spinal epidural anaesthesia (CSEA) or lumbar epidural anaesthesia (LEA) depending on the nature of the procedure.