Wireless Acousto-Piezoelectric Conduit with Aligned Nanofibers for Neural Regeneration.

Peripheral nerve injury (PNI) represents a significant clinical challenge, leading to severe motor and sensory dysfunction, as well as irreversible tissue atrophy. Autograft has been commonly utilized as the clinical gold standard; however, it is limited by donor availability and secondary surgery requirements. Here, an ultrasound-responsive, highly aligned piezoelectric nanofiber nerve guidance conduit (APNF-NGC) is introduced for peripheral nerve regeneration.

Protopine Exerts Anti-Leukemic Effects by Promoting ROS-mediated Inhibition of Survival Signals in Acute Myeloid Leukemia Cells.

Background/aim: The inhibition of differentiation in myeloid progenitor cells is a hallmark of acute myeloid leukemia (AML). The chemotherapy regimen for AML patients, the so-called 7+3 protocol and the survival rate, have remained unchanged for decades, leaving AML one of the most lethal diseases among adults. Differentiation therapy represents a promising approach that aims to induce the maturation of leukemic progenitor cells into non-proliferative, terminally differentiated cells, thereby directly targeting the underlying pathogenesis of the disease.

Study on the applicability and mechanism of Sn-Fe bimetallic oxide catalysts for light-assisted peroxymonosulfate activation in the degradation of chlortetracycline hydrochloride.

Antibiotic pollutants in water pose severe threats to ecosystems and human health, necessitating efficient remediation strategies. Sn-Fe bimetallic oxides, composed of earth-abundant and low-toxicity elements, offer an environmentally friendly catalytic approach for sustainable pollutant degradation. In this study, four Sn-Fe bimetallic oxide catalysts (Fe-SnO(OH), FeSnO(OH), SnFeO, and Sn-FeO) were synthesized via a hydrothermal method by adjusting the amount of NaOH.

Sophora flavescens Aiton alleviates particulate matter-exacerbated asthma through modulation of ROS/ MAPK/autophagy responses.

Ethnopharmacological Relevance: Sophora flavescens Aiton (SFA) has traditionally been used in East Asian medicine for its fever-reducing and dampness-drying properties. It is prescribed for the treatment of fever, skin eczema, asthma, and various inflammatory disorders. Building on these traditional applications, recent studies have reported its anti-asthmatic, anti-inflammatory, and antitumor activities.

HPV E5 Mediates Resistance to Chemotherapy and Radiation by Promoting a Stem Cell-Like Phenotype in Head and Neck Squamous Cell Carcinoma.

Human papillomavirus-associated head and neck squamous cell carcinoma (HPV+ HNSCC) is one of the fastest-rising cancers in the US. While HPV+ HNSCC patients exhibit better responses to chemoradiation compared to HPV- HNSCC patients, a subset still develops recurrent/refractory disease. Here, we investigated the role and mechanisms by which the HPV E5 oncogene promotes resistance to conventional chemotherapy and radiation.

Evaluating the accuracy of the variable flip angle technique for temperature measurement near metallic implants.

This study assessed the accuracy of a T1-based temperature measurement technique for metal-inserted materials using 3T magnetic resonance imaging (MRI). A variable flip angle (VFA) sequence with dual echoes was used to obtain images of a phantom and an experiment. T1 values were calculated when the metal-inserted materials were subjected to heating and were acquired in the proximity of the metal implant of the phantom and tissue.

Self-contracting, battery-free triboelectric wound healing strip with strong wet adhesion.

Conventional wound closure techniques, such as suturing and stapling, often cause infection, delayed healing, and tissue damage, particularly in fragile or compromised tissues. A sutureless, battery-free adhesive strip (SBF strip) is developed to integrate shape-memory-assisted mechanical approximation with impedance-matched electrical stimulation for enhanced tissue repair. The device incorporates a shape memory polymer (SMP) responsive at near-body temperature and a robust wet-adhesive interface (> 200 J m), enabling rapid attachment and uniform closure under mild heating (40 °C).

Ligand-orchestrated transition metal aerogels: a tailored sulfur coordination strategy for superior oxygen evolution catalysis.

A novel strategy was developed to enhance oxygen evolution reaction (OER) performance using a tailored sulfur coordination strategy in ternary transition metal sulfide-oxide aerogels (TMSO). The structural and electronic properties of the aerogels synthesized by a metal coordination-initiated sol-gel method were precisely engineered by tuning Co content and controlling sulfur coordination sites. With increasing cobalt content, enhanced sulfur coordination around nickel facilitated the formation of spike-shaped nanostructures, resulting in superior catalytic performance.

Establishment of a homozygous LMNA knock-out human induced pluripotent stem cell line using CRISPR/Cas9 system.

The LMNA gene encodes lamin A/C, essential components of the nuclear envelope that play crucial roles in maintaining nuclear architecture, mechanotransduction, and gene regulation. LMNA mutations are linked to laminopathies, affecting multiple organ systems, including muscle, adipose tissue, and the cardiovascular system. To investigate LMNA-related disorders, we generated a human-induced pluripotent stem cell (hiPSC) line with a homozygous LMNA frameshift mutation (c.

In-body current path manipulation with minimal attenuation.

Wireless power transfer-based neuromodulation has emerged as a promising alternative to battery-powered implants. However, its practical application is hindered by limited therapeutic efficacy resulting from low power transfer efficiency, shallow penetration depth, and safety concerns. In this study, we report an in-body current path manipulation and concentration for advanced targeted neuromodulation, overcoming the limitations of conventional technologies.

Stability and Exsolution of SrTiFeNiO for the Oxygen Evolution Reaction in an Alkaline Environment.

Developing stable, critical raw material lean catalysts for the OER is essential for low-cost green hydrogen production. In this study, dense, polished pellets of SrTiFeNiO (STFNO) were employed as a model system to investigate intrinsic OER activity and stability under industrially relevant conditions. The well-defined surface and controlled interface between the sample and electrolyte represent a more fundamental approach to studying catalytic performance.

Roles of spin-state dangling bonds and strain in the electronic structure of polytetrafluoroethylene for charge transfer from first-principles.

Utilizing first-principles density functional theory, we computed the surface electronic structure of a polytetrafluoroethylene (PTFE) slab with various dangling bond (DB) configurations. As the number of surface DBs increases, the lowest unoccupied level (LUL) associated with electron affinity (EA) decreases, resulting in a rise in the DBs' formation energy, indicating an unstable state and electron deficiency. Particularly in spinless DB states, only one localized lowest unoccupied surface state (LUSS) forms below the conduction band minimum (CBM).

Gene Affects Hippocampal Sclerosis in Mesial Temporal Lobe Epilepsy.

: Hippocampal sclerosis (HS) is a hallmark of mesial temporal lobe epilepsy (MTLE). However, genetic studies on MTLE patients with HS (MTLE-HS) remain limited, especially in East Asian populations. This study aimed to identify genetic variants associated with MTLE-HS and elucidate their biological relevance through integrative genomic and transcriptomic analyses.

Efficacy and Safety of Ifosfamide and Mesna in Metastatic Castration-Resistant Prostate Cancer after Taxane-Based Chemotherapy and Novel Hormonal Therapy Failure.

Purpose: Limited treatment options exist for patients with metastatic castration-resistant prostate cancer (mCRPC) after the failure of taxane-based chemotherapy and novel hormonal therapy. Here, we report the safety and efficacy of ifosfamide and mesna in patients with mCRPC after the failure of taxane-based chemotherapy and novel hormonal therapy (NCT06236789).

Materials And Methods: Patients with histologically confirmed prostate cancer who had failed taxane-based chemotherapy and novel hormonal therapy received ifosfamide 2,500 mg/m2 and mesna 1,500 mg/m2 on days 1-3, repeated every 21 days.

Establishing 3D organoid models from patient-derived conditionally reprogrammed cells to bridge preclinical and clinical insights in pancreatic cancer.

Background: Pancreatic cancer is a highly lethal malignancy with limited treatment response. Despite advancements in treatment, systemic chemotherapy remains the primary therapeutic approach for over 80% of patients, with no established biomarkers to guide drug selection. Traditional two-dimensional (2D) culture models fail to replicate the tumor microenvironment, necessitating the development of more advanced models, such as three-dimensional (3D) organoid models.

Transcriptome analysis of testes gene expression to explore genetic diversity of Mangalica and Camborough boars.

The testis, an important reproductive organ, is involved in spermatogenesis and steroid hormone secretion and has been the subject of a wide variety of studies. Pigs are often used as model animals for studies on human physiology and disease, and studies on the testicular development of pigs could shed light on human reproduction. Mangalica, an indigenous Hungarian pig breed, has reproductive traits that are different from those of commercial pig breeds.

Azvudine exhibits potent differentiation-inducing effect by targeting the TERT/p21 axis in acute myeloid leukemia.

Acute myeloid leukemia (AML) is a type of hematological malignancy with a poor prognosis caused by diverse genetic mutations. One effective treatment approach is to induce the differentiation of AML cells, which may help curb their unrestrained proliferation. In search of novel differentiation-inducing drug candidates, a phenotypic screen of a chemical library was performed, and Azvudine, a new anti-HIV agent approved by the China FDA in 2021, was identified as the most effective agent.

Transcriptome sequencing reveals distinct atypical parathyroid tumor subtypes.

Atypical parathyroid tumors (APTs) are a rare subtype of parathyroid neoplasms characterized by diagnostic challenges and an uncertain prognosis. This study aimed to validate the subtypes of APTs using transcriptome sequencing. We applied a clustering model developed for our previous study in which we had successfully distinguished parathyroid cancer from adenomas using gene expression patterns.

Electrotherapy and health monitoring with piezoelectric and triboelectric technologies.

The growing need for advanced therapeutic and diagnostic technologies has spurred interest in self-powered systems for electrotherapy and health monitoring. Traditional battery-dependent medical devices (MDs) face limitations, including short operational lifespans and patient discomfort, underscoring the importance of sustainable alternatives. Mechanical energy harvesting technologies, such as piezoelectric and triboelectric nanogenerators (PENGs and TENGs), have emerged as promising solutions, enabling real-time health monitoring and non-invasive electrotherapy by converting biomechanical energy into electricity.

Ultra-Low Core Loss and High-Frequency Permeability Stability in Hot-Press Sintered FeSi Soft Magnetic Composites by FeO Nanoparticles Air Gap Filling.

Soft magnetic materials are crucial in motors, generators, transformers, and many electronic devices. We synthesized the FeSi soft magnetic composites (SMCs) with different doping contents of FeO nanopowders as fillers via the hot-press sintering technique. This work explores the incorporation of high-resistivity magnetic fillers through a novel compaction technique and investigates the influence of FeO nanopowder on the structure and magnetic properties of FeO nanopowder-filled composites.

Idiopathic Intestinal Smooth Muscle Hyperplasia in a French Bulldog: Clinical, Imaging, Capsule Endoscopy, and Histopathological Findings.

A 3-year-old intact female French Bulldog presented with chronic diarrhea, intermittent vomiting, hyporexia, and weight loss over seven weeks. The blood test results were unremarkable, except for mild hypocholesterolemia. Abdominal ultrasonography revealed intestinal wall thickening, particularly in the muscular layer, with focal loss of wall layering in the distal ileum near the ileocecal junction.

Umbilical Cord Blood Plasma Enhances Cellular Repair and Senescence Suppression in Human Dermal Fibroblasts Under Oxidative Stress.

Aging is associated with a gradual decline in cellular function, largely driven by oxidative stress, which leads to cellular senescence. These processes contribute to tissue degeneration and age-related dysfunction. Human dermal fibroblasts (HDFs), critical for maintaining skin structure, are highly vulnerable to oxidative damage, making them key contributors to skin aging.

Performance Evaluation of Reinforced Concrete Beams with Corroded Rebar Strengthened by Carbon Fiber-Reinforced Polymer.

The inefficiency of unreinforced concrete beams as flexural members poses a challenge because concrete's tensile strength is significantly lower than its compressive strength. In response to this challenge, reinforcement bars are commonly employed near the tension zone of reinforced concrete (RC) beams. Nonetheless, structures constructed with RC face challenges such as reduced live load capacity, concrete deterioration, and the corrosion of reinforcement bars over time.

Pulse-Charging Energy Storage for Triboelectric Nanogenerator Based on Frequency Modulation.

Energy harvesting storage hybrid devices have garnered considerable attention as self-rechargeable power sources for wireless and ubiquitous electronics. Triboelectric nanogenerators (TENGs), a common type of energy harvester, generate alternating current-based, irregular short pulses, posing a challenge for storing the generated electrical energy in energy storage systems that typically operate with direct current (DC)-based low-frequency response. In this study, we propose a new strategy that leverages high-frequency response to develop efficient chargeable TENG-supercapacitor (SC) hybrid devices.