Publications by authors named "Samia Boussouar"

Background: Patients with end-stage renal disease (ESRD) are at high cardiovascular risk. The safety and prognostic value of stress cardiovascular magnetic resonance (CMR) in ESRD patients remains unclear as data are lacking due to perceived contrast agent-related risk.

Objectives: The authors aimed to assess the safety and prognostic value of stress CMR in asymptomatic ESRD patients on waitlist for kidney transplantation.

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Erdheim-Chester disease (ECD) is a clonal-inflammatory neoplasm driven by mutations in MAPK pathway proto-oncogenes, such as BRAF. Clinical manifestations are protean, affecting virtually every system. This cohort study analyzed 661 patients with ECD to classify them based on clinical features and mutational profiles using unsupervised clustering.

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Cysts are common abnormalities in imaging, exhibiting a wide range of localizations and pathophysiological mechanisms. Their classification is based on morphological and clinical criteria guiding both diagnostic and therapeutic management. This article primarily focuses on pulmonary cysts, while briefly addressing hepatic and pancreatic cysts.

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Background: Studies have demonstrated that both lower limb arterial calcification and metabolic dysfunction-associated steatotic liver disease (MASLD) are linked to the development of peripheral artery disease. However, the potential relationship between MASLD biomarkers and progression of lower limb arterial calcification in individuals with type 2 diabetes (T2D) remains unclear. This study aimed to investigate whether the biomarkers of MASLD included in the FibroMax® panels are associated with the progression of lower limb arterial calcification in patients with T2D.

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This review highlights the latest advancements in imaging techniques for monitoring respiratory muscles in critically ill patients. At the bedside, conventional ultrasound has been widely adopted to measure diaphragm thickness, thickening and excursion. It has also been used to assess extradiaphragmatic respiratory muscles, including parasternal intercostal and abdominal muscles.

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Recent advances in immunotherapy have significantly improved outcomes for cancer patients. However, therapies such as immune checkpoint inhibitors (ICIs) can lead to immune-related adverse events, including potentially fatal ICI-myocarditis. The diagnosis of ICI-myocarditis is complex, and cardiac MRI plays a crucial role in identifying this condition.

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Article Synopsis
  • Epicardial adipose tissue (EAT) may play a role in the unique atherosclerosis seen in premature coronary artery disease (pCAD), leading to more severe plaque characteristics and higher recurrence of ischemic events.
  • Researchers studied 208 patients, including 104 with pCAD and 104 matched controls, analyzing EAT volume and density using advanced imaging techniques.
  • Results showed pCAD patients had significantly higher EAT volume and lower density compared to controls, indicating that these factors are linked to more severe and potentially vulnerable coronary artery disease features.
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Objectives: The aim of this study was to compare CMR imaging biomarkers between SLE patients and matched controls.

Materials And Methods: Electronic databases were systematically searched from inception until November 2023. All studies reporting CMR imaging data in SLE patients were included.

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Objectives: Vascular complications after venoarterial extracorporeal membrane oxygenation (ECMO) remains poorly studied, although they may highly impact patient management after ECMO removal. Our aim was to assess their frequency, predictors, and management.

Design: Retrospective, observational cohort study.

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Background: Erdheim-Chester disease (ECD) is a rare histiocytosis that may overlap with Langerhans Cell Histiocytosis (LCH). This "mixed" entity is poorly characterized. We here investigated the clinical phenotype, outcome, and prognostic factors of a large cohort of patients with mixed ECD-LCH.

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  • This study investigates the link between non-alcoholic fatty liver disease (NAFLD) biomarkers and coronary artery calcification (CAC) in type 2 diabetes patients, emphasizing the potential for NAFLD biomarkers to enhance cardiovascular risk assessment.* -
  • Researchers examined data from 617 patients with type 2 diabetes, using computed tomography to measure coronary artery calcium scores and FibroMax® panels from blood samples to evaluate liver conditions.* -
  • Results showed a significant association between increasing FibroTest® stages and higher CAC scores, suggesting that NAFLD biomarkers can independently contribute to predicting cardiovascular risk beyond traditional factors.*
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  • This study aims to develop a deep learning method for detecting pulmonary embolism (PE) and calculating its severity using specific metrics on 3D computed tomography pulmonary angiography (CTPA) images with few annotations.
  • The approach includes a series of steps: identifying blood clots, classifying PE presence, and estimating both the Qanadli score and right-to-left ventricle diameter (RV/LV) ratio, utilizing data from a large set of patient examinations.
  • Results showed promising accuracy for PE classification with an area under the curve (AUC) of about 0.87, and solid regression outcomes for estimating severity scores, indicating potential use of AI tools in clinical settings, though further research is needed. *
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  • * Research shows that patients with thymic epithelial tumors (TET), especially thymoma, experience ICI-related myotoxicities more frequently and with greater severity than those with other cancers.
  • * The presence of anti-acetylcholine-receptor antibodies suggests a link between thymic-related autoimmune responses and ICI myotoxicities, indicating that assessing the thymus could help predict these serious side effects in patients undergoing ICI therapy.
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Background: Aortitis is a group of disorders characterized by the inflammation of the aorta. The large-vessel vasculitides are the most common causes of aortitis. Aortitis long-term outcomes are not well known.

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Eosinophilic granulomatosis with polyangiitis (EGPA) is an ANCA-associated vasculitis that affects small size vessels. Only four cases of periaortitis associated with EGPA have been reported in the literature. We report the case of a 67-year-old woman with EGPA who developed periaortitis 11 months after the initiation of dupilumab for uncontrolled asthma with hypereosinophilia.

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  • Systemic lupus erythematosus (SLE) is an autoimmune disease that can lead to rare but severe lung complications (acute lung disease - ALD) which may cause respiratory failure.
  • A study reviewed 14 SLE patients with ALD admitted between 1996 and 2018, highlighting that many cases occurred at the onset of SLE and required intensive care.
  • Treatments included corticosteroids and various forms of respiratory support, with a high survival rate to discharge, but some patients experienced relapses of ALD without developing long-term lung disease.
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Purpose: In 2022, the French Society of Radiology together with the French Society of Thoracic Imaging and CentraleSupelec organized their 13th data challenge. The aim was to aid in the diagnosis of pulmonary embolism, by identifying the presence of pulmonary embolism and by estimating the ratio between right and left ventricular (RV/LV) diameters, and an arterial obstruction index (Qanadli's score) using artificial intelligence.

Materials And Methods: The data challenge was composed of three tasks: the detection of pulmonary embolism, the RV/LV diameter ratio, and Qanadli's score.

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Purpose: The purpose of this study was to investigate the benefit of aortic volumes compared to diameters or cross-sectional areas on three-dimensional (3D) magnetic resonance imaging (MRI) in discriminating between patients with dilated aorta and matched controls.

Materials And Methods: Sixty-two patients (47 men and 15 women; median age, 66 years; age range: 33-86 years) with tricuspid aortic valve and ascending thoracic aorta aneurysm (TAV-ATAA) and 43 patients (35 men and 8 women; median age, 51 years; age range: 17-76 years) with bicuspid aortic valve and dilated ascending aorta (BAV) were studied. One group of 54 controls matched for age and sex to patients with TAV-ATAA (39 men and 15 women; median age, 68 years; age range: 33-81 years) and one group of 42 controls matched for age and sex to patients with BAV (34 men and 8 women; median age, 50 years; age range: 17-77 years) were identified.

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Objective: Among specific autoantibodies in DM, the anti-small ubiquitin-like modifier activating enzyme (SAE) antibody is rare. We aim to describe the clinical characteristics, cancer prevalence, and muscle pathology of anti-SAE-positive DM.

Methods: Patients with a diagnosis of DM and sera positive for the anti-SAE antibody were recruited from 19 centres in this retrospective observational study.

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