Publications by authors named "Felicien Triboulet"
Objective: To examine the course of interstitial lung disease associated with rheumatoid arthritis (RA-ILD) in France on treatment with Janus kinase inhibitors (JAKis) using the MAJIK-SFR registry.
Methods: Prospective national multicentre observational study identifying patients with RA-ILD from the MAJIK-SFR registry. Pulmonary assessment data were collected at JAKi initiation and follow-up visits (6 months, 12 months and a median of 21 months postinclusion), including chest high-resolution CT (HRCT), pulmonary function tests (forced vital capacity (FVC) and diffusing capacity of the lungs for carbon monoxide (DLCO)), acute exacerbations of ILD, respiratory infections and lung cancers.
Article Synopsis
- Immunocompromised patients receiving venoarterial extracorporeal membrane oxygenation (VA-ECMO) exhibit high mortality rates, with 70% dying within 90 days and 75% within a year.
- Factors contributing to these outcomes include older age and elevated pre-ECMO lactate levels, indicating higher risk.
- The study highlights severe complications such as hemorrhages and infections, with immunocompromised individuals having twice the risk of 90-day mortality compared to non-immunocompromised patients.
Article Synopsis
- Systemic lupus erythematosus (SLE) is an autoimmune disease that can lead to rare but severe lung complications (acute lung disease - ALD) which may cause respiratory failure.
- A study reviewed 14 SLE patients with ALD admitted between 1996 and 2018, highlighting that many cases occurred at the onset of SLE and required intensive care.
- Treatments included corticosteroids and various forms of respiratory support, with a high survival rate to discharge, but some patients experienced relapses of ALD without developing long-term lung disease.