The source and dissemination of ARGs in pristine environments: Elucidating the role of migratory birds in the Arctic.

Antibiotic resistance genes (ARGs) are a class of emerging contaminants that significantly threaten public health. In this work, the profiles of ARGs and microbial communities in the soil, sediment, migratory bird, and local deer fecal samples collected from the Arctic were characterized using a metagenomic approach. The results retrieved the baseline profiles of ARGs and identified the role of migratory birds in disseminating ARGs in the Arctic.

The mechanism and effects of remdesivir-induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations.

The antiviral drug remdesivir has been used to treat the growing number of coronavirus disease 2019 (COVID-19) patients. However, the drug is mainly excreted through urine and feces and introduced into the environment to affect non-target organisms, including fish, which has raised concerns about potential ecotoxicological effects on aquatic organisms. Moreover, studies on the ecological impacts of remdesivir on aquatic environments have not been reported.

Hexabromocyclododecane-induced Genotoxicity in Cultured Human Breast Cells through DNA Damage.

To investigate the genotoxicity and reveal the potential toxicological mechanisms of Hexabromocyclododecane (HBCD), human breast cells HBL-100 were exposed to a sequence of HBCD concentrations (0, 5, 10, and 50 mg/L) for 24 h. With a series of zymology and molecular biology methods, we found that HBCD induced dose-dependent oxidative stress on HBL-100 DNA. As revealed in qRT-PCR, activated prognostic factor ATM down-regulated tumor suppressor gene BRCA1 and prompted DNA repair genes hOGG1 and hMTH1 expression in lower concentrations of HBCD (< 10 mg/L).

Aromatic amine contents, component distributions and risk assessment in sludge from 10 textile-dyeing plants.

Aromatic amines (AAs), which are components of synthetic dyes, are recalcitrant to the wastewater treatment process and can accumulate in sludge produced by textile-dyeing, which may pose a threat to the environment. A comprehensive investigation of 10 textile-dyeing plants was undertaken in Guangdong Province in China. The contents and component distributions of AAs were evaluated in this study, and a risk assessment was performed.

Fate of volatile aromatic hydrocarbons in the wastewater from six textile dyeing wastewater treatment plants.

The occurrence and removal of benzene, toluene, ethylbenzene, xylenes, styrene and isopropylbenzene (BTEXSI) from 6 textile dyeing wastewater treatment plants (TDWTPs) were investigated in this study. The practical capacities of the 6 representative plants, which used the activated sludge process, ranged from 1200 to 26000 m(3) d(-1). The results indicated that BTEXSI were ubiquitous in the raw textile dyeing wastewater, except for isopropylbenzene, and that toluene and xylenes were predominant in raw wastewaters (RWs).