Ultrasound-guided Hydrostatic Reduction of Acute Intussusception in Children at a Tertiary Care Center: An Observational Study.

Introduction: Intussusception is common cause of acute emergency responsible for bowel obstruction in infants and toddlers with peak age of incidence between 6-9 months. Ultrasound is imaging modality of choice for diagnosis of intussusception and ultrasound guided hydrostatic enema reduction is standard, nonsurgical, internationally preferred treatment modality for uncomplicated pediatric intussusceptions. This study was aimed to find the outcome of the procedure.

An analytical tool for calculating kerma-to-dose equivalent average conversion coefficients ((10),(3),(0.07), and ICRU 95 recommended dosimetric quantities) for photon beams defined in ISO 4037-1, diagnostic, therapy beams, unfiltered x-rays, and custom photon spectra.

Radiation protection for workers in diverse environments, exposed to varying radiation fields, is a critical aspect of occupational health and safety. To address the challenges in personnel dosimetry, this study introduces excel for kerma-to-dose equivalent conversion (EKDEC), a user-friendly, Excel-based analytical tool designed to calculate the kerma-to-dose equivalent average conversion coefficients for a wide range of photon radiation spectra. EKDEC supports the calculation of dose equivalents for the traditional International Commission on Radiological Protection quantities ((10),(3),(0.

Hydrothermally synthesized 2H-WS nanorods for improved supercapacitor electrode performance.

We demonstrate an emerging and versatile hydrothermal process at three different temperatures (220, 230 and 240 °C) for producing one-dimensional (1D) WS nanorods, which can be easily scaled up. The crystallography, morphology, stoichiometry, lattice-scale and textural features confirmed that the obtained WS products were structurally uniform. Furthermore, the as-synthesized WS nanorods at 240 °C (WS) exhibited enhanced specific surface area, average pore size, charge transport and electrochemical stability compared with WS and WS products.

Modulation of Kv Channel Gating by Light-Controlled Membrane Thickness.

Voltage-gated potassium (Kv) channels are e ssential for shaping action potentials and rely on anionic lipids for proper gating, yet the mechanistic basis of lipid-channel interactions remains unclear. Cryo-electron microscopy studies suggest that, in the down state, arginine residues of the voltage sensor draw lipid phosphates upward, leading to a local membrane thinning of ~5 Å-an effect absent in the open state. To test whether membrane thickness directly affects voltage sensor function, we reconstituted Kv channels from (KvAP) into planar lipid bilayers containing photoswitchable lipids.

Enhanced Site-Specific Fluorescent Labeling of Membrane Proteins Using Native Nanodiscs.

Fluorescent labeling of membrane proteins is essential for exploring their functions, signaling pathways, interaction partners, and structural dynamics. Organic fluorophores are commonly used for this purpose due to their favorable photophysical properties and photostability. However, a persistent challenge is the inaccessibility of the surface-exposed cysteine residues required for site-specific labeling, as these residues often become sequestered within detergent micelles during protein extraction.

Decoding the brain-machine interaction for upper limb assistive technologies: advances and challenges.

Understanding how the brain encodes upper limb movements is crucial for developing control mechanisms in assistive technologies. Advances in assistive technologies, particularly Brain-machine Interfaces (BMIs), highlight the importance of decoding motor intentions and kinematics for effective control. EEG-based BMI systems show promise due to their non-invasive nature and potential for inducing neural plasticity, enhancing motor rehabilitation outcomes.

Structural-morphological insights into optimization of hydrothermally synthesized MoSe nanoflowers for improving supercapacitor applications.

The present work reports a clear and improved hydrothermal methodology for the synthesis of MoSe nanoflowers (MNFs) at 210 °C. To observe the effect of temperature on the fascinating properties, the process temperature was modified by ±10 °C. The as-prepared MNFs were found to consist of 2D nanosheets, which assembled into a 3D flower-like hierarchical morphology van der Waals forces.

Spectroscopic characterization of triazine based covalent organic framework tempted changes in the structure of hemoglobin.

The present study aims to understand changes in the Hemoglobin (Hb) structure in the presence of a triazine based covalent organic framework (COF) through spectroscopic characterization. Covalent Organic Frameworks (COFs) due to their unique properties have been utilized in diverse fields including bio-applications. Utilization of COFs for conjugate formation with proteins will lead to the integration of biology and framework materials that can help in the development of bioconjugates for advanced bio-based applications such as diagnostics, therapeutics, and bioengineering.

The synergistic immunotherapeutic impact of engineered CAR-T cells with PD-1 blockade in lymphomas and solid tumors: a systematic review.

Currently, therapies such as chimeric antigen receptor-T Cell (CAR-T) and immune checkpoint inhibitors like programmed cell death protein-1 (PD-1) blockers are showing promising results for numerous cancer patients. However, significant advancements are required before CAR-T therapies become readily available as off-the-shelf treatments, particularly for solid tumors and lymphomas. In this review, we have systematically analyzed the combination therapy involving engineered CAR-T cells and anti PD-1 agents.

Antitumor activity of genetically engineered NK-cells in non-hematological solid tumor: a comprehensive review.

Recent advancements in genetic engineering have made it possible to modify Natural Killer (NK) cells to enhance their ability to fight against various cancers, including solid tumors. This comprehensive overview discusses the current status of genetically engineered chimeric antigen receptor NK-cell therapies and their potential for treating solid tumors. We explore the inherent characteristics of NK cells and their role in immune regulation and tumor surveillance.

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials.

Optically-induced changes in membrane capacitance may regulate neuronal activity without requiring genetic modifications. Previously, they mainly relied on sudden temperature jumps due to light absorption by membrane-associated nanomaterials or water. Yet, nanomaterial targeting or the required high infrared light intensities obstruct broad applicability.

Oxaloacetate as a Holy Grail Adjunctive Treatment in Gliomas: A Revisit to Metabolic Pathway.

India experiences a significant amount of morbidity and mortality due to gliomas particularly glioblastoma multiforme (GBM), which ranks among the worst cancers. Oxaloacetate (OAA) is a human keto acid that is central to cellular metabolism; it has been recognized by the US FDA for use in GBM patients, triggering a review to revisit the cellular mechanism of its therapeutic action. Various cellular and molecular studies have proposed that instead of fueling the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS), gliomas prefer to use glycolysis (the Warburg effect) to fuel macromolecules for the synthesis of nucleotides, fatty acids, and amino acids for the accelerated mitosis.

Population-wise labeling of sulcal graphs using multi-graph matching.

Population-wise matching of the cortical folds is necessary to compute statistics, a required step for e.g. identifying biomarkers of neurological or psychiatric disorders.

Photolipid excitation triggers depolarizing optocapacitive currents and action potentials.

Optically-induced changes in membrane capacitance may regulate neuronal activity without requiring genetic modifications. Previously, they mainly relied on sudden temperature jumps due to light absorption by membrane-associated nanomaterials or water. Yet, nanomaterial targeting or the required high infrared light intensities obstruct broad applicability.

Experimental IR, Raman, and UV-Vis Spectra DFT Structural and Conformational Studies: Bioactivity and Solvent Effect on Molecular Properties of Methyl-Eugenol.

Structural, conformational, and spectroscopic investigations of methyl-eugenol were made theoretically at the IR, Raman, and UV-vis spectra were investigated and analyzed in light of the computed quantities. Conformational analysis was carried out with the help of total energy vs. dihedral angle curves for different tops, yielding 21 stable conformers, out of which only two have energies below the room temperature relative to the lowest energy conformer.

Exploring binding mode assessment of novel kaempferol, resveratrol, and quercetin derivatives with PPAR-α as potent drug candidates against cancer.

Peroxisome proliferator-activated receptors (PPAR)-α, a ligand-activated transcription factor stands out to be a valuable protein target against cancer. Given that ligand binding is the crucial process for the activation of PPAR-α, fibrate class of synthetic compounds serves as potent agonist for the receptor. However, their serious side effects limit the long-term application in cancer.

ESTIMATION OF PERSONAL DOSE EQUIVALENT HP(0.07) USING CASO4:DY TEFLON DISC-BASED EXTREMITY DOSEMETER.

The radiation workers in India use extremity dosemeter in occupational areas where there is likelihood of receiving significant dose to extremities of the body. Algorithm used for the estimation of whole body dose and extremity dose of wrist are same and is based on slab phantom calibration. However, internationally, different phantoms are recommended for calibration of dosemeter used for extremity and whole body.

A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening.

Non-alcoholic Fatty Liver Disease (NAFLD) or pathological hepatic lipid overload, is considered to affect obese individuals. However, NAFLD in lean individuals is prevalent, especially in South Asian population. The pathophysiology of lean NAFLD is not well understood and most animal models of NAFLD use the high-fat diet paradigm.

Dependence of Precursor Graphite Flake Size on Nitrogen Doping in Graphene Oxide and Its Effect on OER Catalytic Activity.

We report the synthesis of nitrogen-doped graphene oxide, with 5.7-7.0 wt % nitrogen doping, from different sizes of precursor graphite and study its effect on the oxygen evolution reaction (OER) activity of IrO in an acidic medium.

Dietary Vitamin A Intake, Coverage of Vitamin A Megadose Supplementation, and Prevalence of Vitamin A Deficiency among Marginalized Children 6-59 Months in Anganwadis of Chandigarh: A Multistage Cluster Sampling Survey.

Background: Lack of recent local data regarding Vitamin A deficiency, dietary intake, and coverage of biannual high-dose Vitamin A prophylaxis among marginalized children poses challenges for policy change.

Objective: Our study aimed to evaluate the burden of serum Vitamin A deficiency, dietary Vitamin A intake, and current Vitamin A supplementation coverage.

Methodology: We enrolled 216 children aged 6-60 months from 30 Anganwadis of Chandigarh using two-stage cluster sampling.

Correction: Luminescent columnar discotics as highly efficient emitters in pure deep-blue OLEDs with an external quantum efficiency of 4.7.

Correction for 'Luminescent columnar discotics as highly efficient emitters in pure deep-blue OLEDs with an external quantum efficiency of 4.7%' by Joydip De , , 2022, DOI: 10.1039/d1sm01558c.

Luminescent columnar discotics as highly efficient emitters in pure deep-blue OLEDs with an external quantum efficiency of 4.7.

Development of materials that serve as efficient blue emitters in solution-processable OLEDs is challenging. In this study, we report three derivatives of -symmetric 1,3,5-tris(thien-2-yl)benzene-based highly luminescent room temperature columnar discotic liquid crystals (DLCs) suitable as solid-state emitters in OLED devices. When employed in solution-processed OLEDs, one of the derivatives having the highest photoluminescence quantum yield exhibited a maximum EQE of 4.