Age-specific outcomes after transcatheter left atrial appendage occlusion with the watchman device.

Background: Transcatheter left atrial appendage occlusion (LAAO) has become a suitable alternative to anticoagulation in patients with atrial fibrillation (AF). However, outcomes among patients age > 75 years undergoing LAAO are lacking.

Methods: We included 723 consecutive patients with AF undergoing LAAO from August 2015 to March 2020.

Exploring the genetic footprints of the gotra system in the Koṅkaṇī Sārasvata Brahmins.

The gotra system of exogamy is followed by the Brahmin caste group in India. This system restricts the marriage of individuals who belong to the same gotra. In genetic terms, each gotra forms an exogamous group within a population and thereby maintains a lineage.

Role of Morin & Alpha-Lipoic Acid in Diabetic Neuropathic Pain.

Recent studies have shown that plant-derived flavonoids may be useful in the treatment of diabetes. Plants in the Moraceae family are commonly known to contain the bioflavonoid morin. Its pharmacological properties include anti-inflammatory, anti-tumor, anti-diabetic, cardioprotective, neuroprotective, and nephroprotective properties.

Paucity of optineurin gene variants in Indian juvenile open-angle glaucoma patients.

Purpose: In the current study, we have screened the OPTN gene in a cohort of unrelated juvenile open-angle glaucoma (JOAG) patients negative for possible pathogenic variants in CYP1B1 and MYOC genes.

Methods: Polymerase chain reaction (PCR) amplification and sequencing were employed to identify nucleotide variants within the coding sequence and intron-exon boundaries of the OPTN gene in 85 JOAG patients and 100 controls. A pathogenicity prediction of identified variants was performed by six distinct online algorithms.

Unraveling the Photo-Oxygenation Path of a Cyclic Enamine: Structural Insights into Intermediates.

In this study, we report the activation of molecular oxygen by 2,3-dihydropyrrole in endoperoxide mode. The endoperoxide is converted to a 1,4-dioxane derivative upon decomposition. This reaction proceeded stepwise without the use of any catalyst.

Heart's Hidden Signal: A Rare Case of Alternating Bundle Branch Block and Atrioventricular Block.

Introduction: Alternating bundle branch block (ABBB) is a rare cardiac rhythm disorder characterized by alternating occurrence of right BBB and left BBB patterns in consecutive beats. The presence of ABBB in conjunction with atrioventricular block is even more rare.

Case Presentation: A 69-year-old man with no significant medical history presented to the emergency department with dyspnea on exertion, lightheadedness, and dizziness for 3 weeks.

The role of SIX6 gene in juvenile open-angle glaucoma: a subtle contributor to the mutational landscape.

Purpose: Juvenile onset open-angle glaucoma (JOAG) typically affects individuals under 40 years of age, causing a rise in intraocular pressure that results in considerable damage to the optic nerve. To expand the spectrum of mutations linked to JOAG and explore their structural consequences, we examined the genetic alterations within the SIX6 gene.

Study Design: We focused on assessing the whole coding region of the SIX6 gene and the clinical significance of the common SIX6 gene single nucleotide polymorphisms (SNP) rs10483727 and rs33912345, specifically analyzing its association with key clinical factors, including intraocular pressure (IOP), visual acuity, and the vertical cup-to-disc ratio (VCDR).

Role of signaling pathways in endometrial cancer.

Endometrial cancer (EC) is a prevalent gynecological malignancy with a complex molecular landscape, contributing to significant global morbidity and mortality. Dysregulated signaling pathways such as PI3K/AKT/mTOR and RAS/RAF/MEK drive EC progression by promoting uncontrolled cell proliferation, survival, angiogenesis, and metastasis. Mutations in genes like PTEN and PIK3CA further underpin tumor aggressiveness.

The regulatory role of miRNAs/mRNAs axis in cancer: a systematic review.

Objectives: Recently, we and others have demonstrated the involvement of Zinc Finger Antisense 1 () in cancer development. However, the intricate interplay of with miRNAs and mRNAs remains to be fully understood.

Materials And Methods: We followed PRISMA guidelines to retrieve and assess the available literature on the topic "/miRNA/mRNA axis" and "Cancer" from databases such as PubMed, Google Scholar, and ScienceDirect.

Modifications of RNA in cancer: a comprehensive review.

RNA modifications play essential roles in post-transcriptional gene regulation and have emerged as significant contributors to cancer biology. Major chemical modifications of RNA include N6-methyladenosine (mA), 5-methylcytosine (mC), N1-methyladenosine (mA), pseudouridine (ψ), and N7-methylguanosine (mG). Their dynamic regulation highlights their roles in gene expression modulation, RNA stability, and translation.

Identification and structural analysis of pathogenic variants in MYOC and CYP1B1 genes in Indian JOAG patients.

Purpose: Juvenile onset open-angle glaucoma (JOAG) manifests in individuals under the age of 40, resulting in elevated intraocular pressure and significant optic nerve damage. To broaden the spectrum of mutations associated with JOAG and to determine their specific structural implications, we examined Myocilin and Cytochrome P450 1B1 gene in a cohort of 111 unrelated North Indian patients diagnosed with JOAG.

Study Design: A clinical and experimental study.

Cyclic (Alkenyl)(Amino)Carbene (CAAC): Introducing a Member to the Cyclic (Alkyl)(Amino)Carbenes Family Featuring a Narrow Energy Gap.

Herein, we report the carbene-like activity of a nonisolable, highly ambiphilic cyclic (alkenyl)(amino)carbene (CAAC, ), which is stabilized as [(CAAC)(H)N(SiMe)] (). This protected form () is stable in air and moisture. Compound can be used as a carbene source through deamination upon heating to 130-140 °C.

Analysis of interleukin-6 gene polymorphism and its serum levels in Indian age-related macular degeneration patients.

Background: Age-related macular degeneration (AMD) is a complex condition involving multiple factors. The condition is associated with numerous inflammatory indicators, including cytokines. Single-nucleotide polymorphisms in cytokine genes can also modify gene expression, perhaps contributing to the development of the disease.

Global Health Inequities in Electrophysiology Care: A State-of-the-Art Review.

This state-of-the-art review examines disparities in the diagnosis, management, and outcomes of cardiac arrhythmias globally. These arrhythmias include atrial fibrillation, ventricular tachyarrhythmias underlying sudden cardiac death, and bradyarrhythmias associated with sinus node and atrioventricular node disease. Arrhythmias in low- and middle-income countries often result in higher mortality rates due to complex and poorly documented risk factors, lack of clinical expertise among health care personnel, lack of sufficient infrastructure, and challenges in access to care.

Sex-related differences in patients with acute myocardial infarction complicated by cardiogenic shock: A systematic review and meta-analysis.

Background: This review aims to analyze sex-related differences in patients with acute myocardial infarction (AMI) complicated by cardiogenic shock (CS).

Methods: 10 studies were retrieved from PubMed and Embase comparing outcomes between men and women admitted with AMI complicated by CS. Pooled log odds ratios (OR) were calculated for binary outcomes using the Mantel-Haenszel method, and Hedges' g with the inverse-variance method was used for continuous outcomes.

The hidden architects of the genome: a comprehensive review of R-loops.

Three-stranded DNA: RNA hybrids known as R-loops form when the non-template DNA strand is displaced and the mRNA transcript anneals to its template strand. Although R-loop formation controls DNA damage response, mitochondrial and genomic transcription, and physiological R-loop formation, imbalanced formation of R-loop can jeopardize a cell's genomic integrity. Transcription regulation and immunoglobulin class switch recombination are two further specialized functions of genomic R-loops.

The miRNA and PD-1/PD-L1 signaling axis: an arsenal of immunotherapeutic targets against lung cancer.

Lung cancer is a severe challenge to the health care system with intrinsic resistance to first and second-line chemo/radiotherapies. In view of the sterile environment of lung cancer, several immunotherapeutic drugs including nivolumab, pembrolizumab, atezolizumab, and durvalumab are currently being used in clinics globally with the intention of releasing exhausted T-cells back against refractory tumor cells. Immunotherapies have a limited response rate and may cause immune-related adverse events (irAEs) in some patients.

Immune-Related Long Non-Coding RNA Signature Determines Prognosis and Immunotherapeutic Coherence in Esophageal Cancer.

Objectives: Aim of this study was to explore the immune-related lncRNAs having prognostic role and establishing risk score model for better prognosis and immunotherapeutic coherence for esophageal cancer (EC) patients.

Methods: To determine the role of immune-related lncRNAs in EC, we analyzed the RNA-seq expression data of 162 EC patients and 11 non-cancerous individuals and their clinically relevant information from the cancer genome atlas (TCGA) database. Bioinformatic and statistical analysis such as Differential expression analysis, co-expression analysis, Kaplan Meier survival analysis, Cox proportional hazards model, ROC analysis of risk model was employed.

Six new species of L. (Zingiberales, Zingiberaceae) from the Eastern Himalayas and Northeast India.

We describe six new species in the genus L.: , , , , , collected from the Indian part of the Eastern Himalayas (West Bengal) and Northeast India. We provide a detailed morphological description of all six species along with photographic plates, distribution maps, and tentative conservation assessments.

Assessing the arrhythmogenic propensity of fibrotic substrate using digital twins to inform a mechanisms-based atrial fibrillation ablation strategy.

Atrial fibrillation (AF), the most common heart rhythm disorder, may cause stroke and heart failure. For patients with persistent AF with fibrosis proliferation, the standard AF treatment-pulmonary vein isolation-has poor outcomes, necessitating redo procedures, owing to insufficient understanding of what constitutes good targets in fibrotic substrates. Here we present a prospective clinical and personalized digital twin study that characterizes the arrhythmogenic properties of persistent AF substrates and uncovers locations possessing rotor-attracting capabilities.

Biochemical characterization of a high affinity phosphate transporter (PiPT) from root endophyte fungus Piriformospora indica.

We have functionally characterized the high-affinity phosphate transporter (PiPT) from the root endophyte fungus Piriformospora indica. PiPT belongs to the major facilitator superfamily (MFS). PiPT protein was purified by affinity chromatography (Ni-NTA) and Size Exclusion Chromatography (SEC).

Hepatoprotective Potential of (Curry Leaves) against Xenobiotics, Heavy Metals, and Hepatotoxic Agents: A Comprehensive Review.

Liver disease, responsible for two million annual deaths, causes Chronic Liver Disease (CLD) and cirrhosis, causing roughly a million deaths yearly. Treatment options for liver injury induced by hepatotoxicity vary, including medication (N-acetylcysteine, corticosteroids, and ursodeoxycholic acid), lifestyle changes, and sometimes liver transplant. However, effectiveness varies, and some treatments carry risks and side effects, highlighting the need for improved therapeutic approaches.

Understanding the HPV associated cancers: A comprehensive review.

Human papillomavirus (HPV), a common cause of sexually transmitted diseases, may cause warts and lead to various types of cancers, which makes it important to understand the risk factors associated with it. HPV is the leading risk factor and plays a crucial role in the progression of cervical cancer. Viral oncoproteins E6 and E7 play a pivotal role in this process.

Evolutionary patterns of variations in chromosome counts and genome sizes show positive correlations with taxonomic diversity in tropical gingers.

Premise: Cytogenetic traits such as an organism's chromosome number and genome size are taxonomically critical as they are instrumental in defining angiosperm diversity. Variations in these traits can be traced to evolutionary processes such as polyploidization, although geographic variations across cytogenetic traits remain underexplored. In the pantropical monocot family Zingiberaceae (~1500 species), cytogenetic traits have been well documented; however, the role of these traits in shaping taxonomic diversity and biogeographic patterns of gingers is not known.