Green nanoscience for healthcare: Advancing biomedical innovation through eco-synthesized nanoparticle.

Green synthesis is an eco-friendly and sustainable approach to nanoparticle production using biological sources such as plant extracts and microorganisms. Unlike traditional chemical methods, it aligns with green chemistry principles by reducing toxic reagents, minimizing waste, and lowering environmental impact. Green-synthesized nanoparticles have shown great potential, especially in biomedicine, for targeted drug delivery, antimicrobial treatments, and imaging applications.

Juvenile Trabecular Ossifying Fibroma of the Orbit.

An 11-year-old male presented to the hospital with severe headache, nausea, and proptosis of the OD. Imaging revealed a 4 × 3 × 1 cm mass originating in the right orbital roof with adjacent bony remodeling, a calcific rim along the inferior extent of the lesion, and a heterogenous central component with hyper- and hypo-dense components. An orbitotomy with biopsy with near-total resection was performed, which yielded a diagnosis of juvenile trabecular ossifying fibroma, a tumor rarely found in the orbit.

A Cross-Sectional Study of Depression in Rheumatoid Arthritis Patients at a Tertiary Care Center.

Background: Rheumatoid arthritis (RA) is a chronic autoimmune condition often linked with depression, worsening symptoms, and lowering the quality of life. This study evaluated the prevalence of depression in female RA patients and its relationship with RA activity and inflammatory markers.

Material And Methods: A cross-sectional study was conducted over 18 months, involving 185 female RA patients with depression, diagnosed using DSM-5 criteria.

Heterotopic calcification in a child presenting as acute on chronic myelopathy.

Purpose: Heterotopic calcification (HC) is a rarely reported pathology of aberrant bone deposition in extraskeletal tissue, most commonly outside of the central nervous system. While some of these findings may be incidental and asymptomatic, patients with symptomatic cord compression due to HC require consideration for expedited surgical intervention. We present the first described pediatric case of HC of the cervical spine causing spinal cord compression in a patient presenting with acute weakness and paresthesias following a minor trauma.

Metagenomics and plant-microbe symbioses: Microbial community dynamics, functional roles in carbon sequestration, nitrogen transformation, sulfur and phosphorus mobilization for sustainable soil health.

Biogeochemical cycles are fundamental processes that regulate the flow of essential elements such as carbon, nitrogen, and phosphorus, sustaining ecosystem productivity and global biogeochemical equilibrium. These cycles are intricately influenced by plant-microbe symbioses, which facilitate nutrient acquisition, organic matter decomposition, and the transformation of soil nutrients. Through mutualistic interactions, plants and microbes co-regulate nutrient availability and promote ecosystem resilience, especially under environmental stress.

Should We Stop Assessing Intraoperative Frozen Section Marrow Margins During Ewing Sarcoma Resection?

Background: Ewing sarcoma is a rare and highly aggressive pediatric bone cancer that is histologically composed of small, round blue cells. These histologic findings can make it difficult to assess intraoperative frozen section bone marrow margins because the bone marrow that regenerates after preoperative chemotherapy has a similar appearance, especially on frozen section analysis. Prior studies have more broadly questioned the utility of intraoperative assessment of bone marrow margins using frozen sections during the resection of bone sarcomas; however, to our knowledge, no prior study has specifically characterized the accuracy or clinical utility of evaluating bone marrow margins on frozen sections during long bone Ewing sarcoma resection.

Corrigendum to: Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine.

The authors of the article titled "Advances in Genetic Reprogramming: Prospects from Developmental Biology to Regenerative Medicine" (Dhanjal DS, Singh R, Sharma V, Nepovimova E, Adam V, Kuca K, Chopra C. Curr Med Chem. 2024; 31(13): 1646-1690.

What Is the Prevalence and Fate of Myxoid Soft-Tissue Tumors With an Indeterminate Diagnosis Prior to Resection?

Introduction: Differentiating benign and malignant myxoid soft-tissue tumors preoperatively can be challenging due to shared clinical, imaging, and histologic features. Biopsy specimens are frequently described as "low-grade myxoid neoplasms" without benign or malignant classification (ie, indeterminate). Our purpose is to evaluate the prevalence and prognosis of myxoid tumors with an indeterminate diagnosis before resection.

Assessing knowledge and awareness levels regarding cervical cancer and HPV vaccination in the Jammu regions.

Background And Objectives: Cervical cancer global burden is highly skewed towards poor countries primarily due to lack of awareness, poor screening, and low uptake of prophylactic vaccines. The purpose of our study is to educate and raise awareness among young girls and women about the importance of cervical screening and HPV vaccination.

Materials And Methods: The present study, conducted from January 2023 to December 2023, focused on students, teachers, housewives, and healthcare professionals in the Jammu region to assess their awareness of cervical cancer and the HPV vaccine.

Effect of mindfulness-based intervention on perceived stress among breast cancer patients undergoing chemotherapy.

Introduction: Breast cancer is the second most prevalent disease among women in India and one of the most dangerous and lethal. Chemotherapy-treated breast cancer patients may have perceived stress, which is defined as emotions of mental or physical exhaustion that make them feel angry or anxious. Mindfulness-based intervention (MBI) gives some ideas in line with the conventional mindfulness technique.

Studies on the ameliorative potential of Rheum webbianum rhizome extracts on 1,2-dimethylhydrazine (DMH) induced colorectal cancer and associated hepatic and haematological abnormalities in swiss albino rats.

Ethnopharmacological Relevance: Rheum webbianum Royle (RW) holds significant ethnopharmacological importance owing to its 5000-year history of cultivation for medicinal and culinary purposes. Demonstrating therapeutic advantages in traditional and contemporary medical practices, RW exhibits key pharmacological effects including anticancer activity, gastrointestinal control, anti-inflammatory properties, and suppression of fibrosis. Despite its recognized vast bioactivities in ethnopharmacology, its efficacy against the colorectal cancer (CRC) remains incompletely understood.

Characterization of thermostable carboxypeptidase from high-altitude hot spring metagenome.

This study explored the metagenome of the Pir Panjal Hot Spring (PPHS) to identify thermostable hydrolases. The carboxypeptidase (CarP) gene was successfully amplified and cloned into Escherichia coli DH5-α cells, followed by expression in E. coli BL21-DE3 cells.

Sclerosing Perineurioma of the Orbit.

A 7-week-old boy presented to pediatric ophthalmology with a mass inferior to the medial canthus of the OS that was first noticed on day 3 of life. Crigler massages, warm compresses, and moxifloxacin HCl drops were administered without resolution of symptoms. Probing and irrigation for a presumed dacryocystocele were performed, but the nasolacrimal system was patent, and the mass persisted after the procedure.

Comparison of clinical outcomes between femtosecond laser-assisted cataract surgery versus conventional phacoemulsification in vitrectomized eyes - A prospective interventional study.

Purpose: To compare the clinical outcomes and surgical safety between femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification cataract surgery (CPCS) in vitrectomized eyes.

Methods: A prospective interventional comparative study was conducted at a tertiary eye care center. Sixty consecutive cases requiring cataract surgery following pars plana vitrectomy were allocated into Group 1 ( n = 30), who underwent FLACS with intraocular lens implantation, and Group 2 ( n = 30), who underwent CPCS with intraocular lens implantation, and followed up for 3 months.

C-H Bond Oxidation by Mn-Oxo Complexes: Hydrogen-Atom Tunneling and Multistate Reactivity.

The reactivity of six Mn-oxo complexes in C-H bond oxidation has been examined using a combination of kinetic experiments and computational methods. Variable-temperature studies of the oxidation of 9,10-dihydroanthracene (DHA) and ethylbenzene by these Mn-oxo complexes yielded activation parameters suitable for evaluating electronic structure computations. Complementary kinetic experiments of the oxidation of deuterated DHA provided evidence for hydrogen-atom tunneling in C-H bond oxidation for all Mn-oxo complexes.

Replication study identified EFEMP1 association with varicose vein predisposition among Indians.

Background: Varicose vein is a chronic condition that affects the lower extremities of the human body. Several factors have been implicated in the development of this disease, viz age, gender, weight, height and prolonged standing. Recently, genome-wide studies have identified genetic biomarkers that are associated with varicose veins in different ethnic groups.

Algae-Mediated Removal of Prevalent Genotoxic Antibiotics: Molecular Perspective on Algae-Bacteria Consortia and Bioreactor-Based Strategies.

Antibiotic pollution poses a potential risk of genotoxicity, as antibiotics released into the environment can induce DNA damage and mutagenesis in various organisms. This pollution, stemming from pharmaceutical manufacturing, agriculture, and improper disposal, can disrupt aquatic ecosystems and potentially impact human health through the consumption of contaminated water and food. The removal of genotoxic antibiotics using algae-mediated approaches has gained considerable attention due to its potential for mitigating the environmental and health risks associated with these compounds.

Surgical Margins in Musculoskeletal Sarcoma.

» Negative margin resection of musculoskeletal sarcomas is associated with reduced risk of local recurrence.» There is limited evidence to support an absolute margin width of soft tissue or bone that correlates with reduced risk of local recurrence.» Factors intrinsic to the tumor, including histologic subtype, grade, growth pattern and neurovascular involvement impact margin status and local recurrence, and should be considered when evaluating a patient's individual risk after positive margins.

Valorization of non-edible fruit seeds into valuable products: A sustainable approach towards circular bioeconomy.

Global imperatives have recently shown a paradigm shift in the prevailing resource utilization model from a linear approach to a circular bioeconomy. The primary goal of the circular bioeconomy model is to minimize waste by effective re-usage of organic waste and efficient nutrient recycling. In essence, circular bioeconomy integrates the fundamental concept of circular economy, which strives to offer sustainable goods and services by leveraging biological resources and processes.

Unraveling molecular signatures in rare bone tumors and navigating the cancer pathway landscapes for targeted therapeutics.

Rare cancers (RCs), which account for over 20% of cancer cases, face significant research and treatment challenges due to their limited prevalence. This results in suboptimal outcomes compared to more common malignancies. Rare bone tumors (RBTs) constitute 5-10% of rare cancer cases and pose unique diagnostic complexities.

Targeted Inhibition of the PI3K/Akt/mTOR Signaling Axis: Potential for Sarcoma Therapy.

Sarcoma is a heterogeneous group of malignancies often resistant to conventional chemotherapy and radiation therapy. The phosphatidylinositol-3-kinase/ protein kinase B /mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway has emerged as a critical cancer target due to its central role in regulating key cellular processes such as cell growth, proliferation, survival, and metabolism. Dysregulation of this pathway has been implicated in the development and progression of bone sarcomas (BS) and soft tissue sarcomas (STS).

Building the taxonomic profile of the Riniaie Marwah hot spring of Kishtwar in Jammu and Kashmir: the first high-throughput sequencing-based metagenome study.

Background And Objectives: Rinaie Marwah hot spring Kishtwar (RMHSK) is one of the geothermal springs located at 33°51'51″N 75°32'07″E with an elevation of 2134 meters above sea level in Jammu and Kashmir, India. We aimed to study the microbial diversity of this geothermal spring using metagenomics.

Materials And Methods: In the present study, physiochemical parameters including temperature (65-75°C), pH (6.

3D Specimen Scanning and Mapping in Musculoskeletal Oncology: A Feasibility Study.

Background: Surgical resection is the primary treatment for bone and soft tissue tumors. Negative margin status is a key factor in prognosis. Given the three-dimensional (3D) anatomic complexity of musculoskeletal tumor specimens, communication of margin results between surgeons and pathologists is challenging.

Metagenomics in the fight against zoonotic viral infections: A focus on SARS-CoV-2 analogues.

Zoonotic viral infections continue to pose significant threats to global public health, as highlighted by the COVID-19 pandemic caused by the SARS-CoV-2 virus. The emergence of SARS-CoV-2 served as a stark reminder of the potential for zoonotic transmission of viruses from animals to humans. Understanding the origins and dynamics of zoonotic viruses is critical for early detection, prevention, and effective management of future outbreaks.