The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomised controlled trial.

Background: The combination of short- and long-acting local anaesthetics is traditionally associated with reduced block duration, though evidence remains inconsistent.

Objectives: To investigate the effects of a fixed or reduced dose of a long-acting local anaesthetic (ropivacaine) mixed with a short-acting agent (lidocaine-epinephrine) on duration of analgesia and sensory onset time in lateral infraclavicular blocks.

Design: Randomised, blinded, active-controlled superiority trial.

Brachial plexus nerve block versus haematoma block for closed reduction of distal radius fracture in adults: The BLOCK Trial - a protocol for a multicentre randomised controlled trial.

Introduction: Distal radius fractures account for one-fifth of all fractures in the active elderly population and may cause chronic pain, loss of hand function and reduced work productivity, imposing a significant socioeconomic burden. Most are initially treated with closed reduction and casting, but 30% subsequently require surgery due to insufficient realignment. The current approaches for analgesia for closed reduction are suboptimal.

Analgesic Effect of Cocaine and Lidocaine/Xylometazoline in Healthy Volunteers Undergoing Awake Nasal Intubation: A Randomized Controlled Crossover Trial.

Background: Several drugs may be used to minimize pain during nasal intubation in awake patients. We hypothesized that the analgesic effect of cocaine would be at least as good (non-inferior) as that of lidocaine with xylometazoline rated as maximum pain felt during awake nasal intubation of healthy volunteers.

Methods: We conducted an outcome assessor blinded, randomized, triple crossover, non-inferiority study following approval from the local research ethics committee and the national medicine agency.

Testing of pre-operative peripheral nerve blocks in randomised controlled trials: A scoping review protocol.

Background: Peripheral nerve blocks are widely used for anaesthesia in upper or lower limb surgery, but the methods used to assess their success vary substantially across randomised controlled trials. Standardised reporting of how peripheral nerve blocks are tested and how success is defined is essential for ensuring the validity and comparability of clinical research and correct clinical implementation of nerve blocks. This scoping review aims to map existing research practices and assess the extent to which trials provide reporting on peripheral nerve block evaluation.

Analgesia and anesthesia for closed reduction of dislocated total hip arthroplasty: Protocol for a scoping review.

Background: Total hip arthroplasty is a common surgical procedure, but dislocation remains a significant complication often requiring closed reduction. Current anesthetic practices for closed reduction of total hip arthroplasty vary widely, and evidence on the efficacy, safety, and cost-effectiveness of different anesthetic and analgetic regimens is limited.

Methods: This scoping review follows the Joanna Briggs Institute (JBI) guidelines and PRISMA-ScR framework.