The effect of combining lidocaine and ropivacaine on the duration and onset time of an ultrasound-guided infraclavicular brachial plexus nerve block: A randomised controlled trial.

Background: The combination of short- and long-acting local anaesthetics is traditionally associated with reduced block duration, though evidence remains inconsistent.

Objectives: To investigate the effects of a fixed or reduced dose of a long-acting local anaesthetic (ropivacaine) mixed with a short-acting agent (lidocaine-epinephrine) on duration of analgesia and sensory onset time in lateral infraclavicular blocks.

Design: Randomised, blinded, active-controlled superiority trial.

Effectiveness of Combining Lidocaine and Ropivacaine on the Duration of Analgesia and Anesthesia of an Infraclavicular Brachial Plexus Block.

Background: Combining local anesthetics for peripheral nerve blocks may change block characteristics, resulting in altered onset and block duration. We aimed to investigate the block characteristics of an infraclavicular brachial plexus block regarding block duration, pain after block cessation, and patient satisfaction by using a combination of lidocaine-epinephrine and ropivacaine.

Methods: In this retrospective cohort study, 103 patients undergoing ambulatory hand or wrist surgery received an infraclavicular brachial plexus block with either a combination of ropivacaine 5 mg/mL combined with lidocaine 20 mg/mL and epinephrine 5 µg/mL (COMBI group) or only ropivacaine 5 mg/mL (ROPI group).

Testing of pre-operative peripheral nerve blocks in randomised controlled trials: A scoping review protocol.

Background: Peripheral nerve blocks are widely used for anaesthesia in upper or lower limb surgery, but the methods used to assess their success vary substantially across randomised controlled trials. Standardised reporting of how peripheral nerve blocks are tested and how success is defined is essential for ensuring the validity and comparability of clinical research and correct clinical implementation of nerve blocks. This scoping review aims to map existing research practices and assess the extent to which trials provide reporting on peripheral nerve block evaluation.

Peripheral nerve blocks for closed reduction of distal radius fractures-A systematic review with meta-analysis and trial sequential analysis.

Background: Peripheral nerve blocks may provide better conditions for closed reduction of distal radius fractures as compared to other more frequently used modalities. In this systematic review, we evaluate existing evidence on the effect and harm of peripheral nerve blocks for closed reduction of distal radius fractures in adults.

Methods: We performed a systematic review with meta-analysis and trial sequential analysis including trials investigating the use of peripheral nerve blocks for closed reduction of distal radius fractures.

Mixing short- and long-acting local anaesthetics in peripheral nerve blocks: Protocol for a systematic review and meta-analysis.

Introduction: This protocol describes a systematic review and meta-analysis to evaluate the clinical effects of mixing short- and long-acting local anaesthetics in peripheral nerve blocks. Clinicians often combine short- and long-acting local anaesthetics to achieve a briefer onset time. However, this may come with a prize, namely a shorter total duration of the block, which is of clinical importance.

Safety of High-Dose Vitamin D Supplementation Among Children Aged 0 to 6 Years: A Systematic Review and Meta-analysis.

Importance: Several health benefits of vitamin D have been suggested; however, the safety of high-dose supplementation in early childhood is not well described.

Objective: To systematically assess the risk of adverse events after high-dose supplementation with vitamin D reported in published randomized clinical trials.

Data Sources: PubMed and ClinicalTrials.