Lagrangian quantification of atmospheric moisture sources for extreme rainfall events over India during the 2023 summer monsoon.

Extreme rainfall during the Indian Summer Monsoon (ISM) accounts for approximately 27 % of the total seasonal rainfall. Most of this moisture is transported from the Indian Ocean. Amid ongoing warming of the Indian Ocean, 2023 stood out as one of the warmest monsoon years on record.

Advancements in predicting soil liquefaction susceptibility: a comprehensive analysis of ensemble and deep learning approaches.

Liquefaction is a phenomenon that occurs when there is a loss of strength in wet and cohesionless soil due to higher pore water pressures, and as a result, the effective stress is reduced due to dynamic loading. A construction site should first investigate the site for liquefaction, and for analyzing liquefaction, the most accurate method should be selected, which provides the most accurate results. In this work, a detailed investigation is performed on the effectiveness of ensemble learning and deep learning (DL) models in assessing the liquefaction susceptibility of soil deposits from a large database consisting of cone penetration test (CPT) measurements and field liquefaction performance observations of historical earthquakes.

Large asymptomatic pseudoaneurysm post open partial nephrectomy - A rare case.

A 52-year-old female presented with a history of left partial nephrectomy performed 1 year ago for a left renal mass. She was asymptomatic and was under post-operative follow-up. A contrast-enhanced computed tomography scan of the abdomen was obtained which revealed a large renal artery pseudoaneurysm (of size 79 mm ×67 mm ×78 mm).

Patient tolerance during rigid cystoscopy: An observational study comparing lignocaine hydrochloride gel and tramadol with lignocaine.

Introduction: In the field of urology, cystoscopy is one of the most common operations. A rigid cystoscope was used for each cystoscopy in this investigation. Given its dual function as a lubricant and local anesthetic, topical lignocaine gel is the most often utilized agent.

Revisiting epigenetic regulation in cancer: Evolving trends and translational implications.

Cancer is a leading cause of mortality worldwide. The evolving role of epigenetics and tumor microenvironments of cancer pose significant challenges to the management of cancer. Besides genetics, epigenetic changes play a crucial role in the alteration of cellular machinery, progression, metastasis, epithelial-mesenchymal transition, and chemoresistance.

Leveraging nanomaterials for ultrasensitive biosensors in early cancer detection: a review.

Cancer remains a major global health challenge with a high mortality rate, as evidenced by the rise in new cases every year. Conventional diagnostic methods like PET scans, MRIs, and biopsies, despite being widely used, suffer from significant drawbacks such as high radiation exposure, difficulty in distinguishing malignant from benign tumors, and invasiveness. Early detection, which is crucial for improving treatment outcomes and survival rates, is hindered by the asymptomatic nature of early-stage cancer and the limitations of current diagnostic tools.

Computational supported experimental insights in adsorption of Congo Red using ZnO/doped ZnO in aqueous solution.

The rapid growth of industrialisation has led to the discharge of harmful effluents into water bodies, severely disrupting the balance of ecosystems. The detection and removal of dyes from wastewater remains a significant challenge. In this study, we report the synthesis of zinc oxide (ZnO) and its doped derivatives through a facile chemical method, followed by comprehensive characterisation and analysis to assess their potential in various applications.

Exploring the unfolding pathways of protein families using Elastic Network Model.

We explore how a protein's native structure determines its unfolding process. We examine how the local structural features, like shear, and the global structural properties, like the number of soft modes, change during unfolding. Simulations are performed using a Gaussian Network Model (GNM) with bond breaking for both thermal and force-induced unfolding scenarios.

Atomically dispersed single-atom catalysts (SACs) and enzymes (SAzymes): synthesis and application in Alzheimer's disease detection.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory loss. Conventional diagnostic methods, such as neuroimaging and cerebrospinal fluid analysis, typically detect AD at advanced stages, limiting the efficacy of therapeutic interventions. Early detection is crucial for improving patient condition by enabling timely administration of treatments that may decelerate disease progression.

A review on the use of composites of a natural protein, silk fibroin with Mxene/carbonaceous materials in biomedical science.

Silk fibroin (SF), a natural biodegradable and biocompatible protein, has garnered significant attention in biomedical applications due to its impressive properties, including excellent biocompatibility, biodegradability, and mechanical resilience. Nevertheless, its broader usage faces obstacles by its insufficient mechanical strength and electrical conductivity. In order to address these constraints, recent studies have concentrated on combining SF with cutting-edge nanomaterials like MXene and carbon-based materials.

Unveiling the impact of dyes on aquatic ecosystems through zebrafish - A comprehensive review.

Dye industry plays an essential role in industrial development, contributing significantly to economic growth and progress. However, its rapid expansion has led to significant environmental concerns, especially water pollution and ecosystem degradation due to the discharge of untreated or inadequately treated dye effluents. The effluents introduce various harmful chemicals altering water quality, depleting oxygen levels, harming aquatic organisms, and disrupting food chains.

Investigation of structural, optical and mechanical behaviour of pure and Cr doped L-asparagine monohydrate single crystals.

Pure and chromium (Cr) doped L-asparagine monohydrate (LAM) single crystals were grown by using evaporation controlled solution growth technique. XRD analysis confirmed the orthorhombic crystal system with space group P222 of grown crystals. Cr-incorporation decreased the cell parameters and unit cell volume of the crystals.

Prognostic significance of Klotho expression in patients with renal cell carcinoma.

Introduction: Various molecular markers have been investigated in renal cell carcinoma (RCC) without significant reliability. We analyzed Klotho (tumor suppressive protein) expression in RCC to investigate its association with tumor-stage, grade, disease-free-survival (DFS) and overall-survival (OS).

Methods: Data of histologically confirmed patients of RCC with complete clinical follow-up were retrieved from Medical-Record-Library.

Three-Port Laparoscopic Cholecystectomy as a Safe and Feasible Alternative to the Conventional Four-Port Laparoscopic Cholecystectomy.

Aims A prospective observational study was performed to assess the feasibility and safety of three-port laparoscopic cholecystectomy. Parameters comprising age, sex, number of cases in which intra-operative difficulty were encountered, and outcomes such as number of cases that required conversion to four-port laparoscopic cholecystectomy, postoperative pain on the visual analog scale (VAS), and postoperative hospital stay were assessed. We also documented difficult cases that were operated successfully with three ports, and the number of cases that needed conversion to four ports along with the reason for the conversion.

Frequency noise measurements using coherent self-heterodyne detection.

We demonstrate a refined way to extract the frequency noise (FN) spectrum of lasers by tailoring the delay in a conventional delayed self-heterodyne setup to sub-coherence lengths. The method achieves direct proportionality between electrical spectrum analyzer traces and the FN spectrum, which provide the intrinsic linewidth of the lasers. This proposed method is validated by comparing the FN spectrum with that obtained from a commercial frequency noise analyzer.

Luminous Insights: Exploring Organic Fluorescent "Turn-On" Chemosensors for Metal-Ion (Cu, Al, Zn, Fe) Detection.

There are several metal ions that are vital for the growth of the environmental field as well as for the biological field but only up to the maximum limit. If they are present in excess, it could be hazardous for the human health. With the growing technology, a series of various detection techniques are employed in order to recognize those metal ions, some of them include voltammetry, electrochemical methods, inductively couples, etc.

Ensemble learning-based early detection of influenza disease.

Across the world, the seasonal disease influenza is a respiratory illness that impacts all age groups in many ways. Its symptoms are fever, chills, aches, pains, headaches, fatigue, cough, and weakness. Seasonal influenza can cause mild to severe illness and lead to death at times.

The curious case of genome packaging and assembly in RNA viruses infecting plants.

Genome packaging is the crucial step for maturation of plant viruses containing an RNA genome. Viruses exhibit a remarkable degree of packaging specificity, despite the probability of co-packaging cellular RNAs. Three different types of viral genome packaging systems are reported so far.

Characterization of thiamine pyrophosphokinase of vitamin B1 biosynthetic pathway as a drug target of .

Vitamin B1 is an essential cofactor for enzymes involved in the metabolism of carbohydrates, particularly Transketolases. These enzymes are amenable to therapeutic interventions because of their specificity. In the final step of the Vitamin B1 biosynthesis pathway, Thiamine Pyrophosphokinase (TPK) converts thiamin into its active form, Thiamin Pyrophosphate (TPP), allowing researchers to investigate the functional importance of this enzyme and the pathway's dispensability in , a protozoan parasite that causes visceral leishmaniasis.

Congenital Diaphragmatic Hernia With Intra Thoracic Gastric Volvulus: A Rare, Life-Threatening Combination.

Congenital diaphragmatic hernia (CDH) is a known cause of secondary gastric volvulus (GV). Both entities are life-threatening, either alone or in exceedingly rare instances when they occur in combination. Here, we describe one such rare combination of CDH and secondary GV in a nine-year-old boy, who presented to us with recurrent episodes of abdominal pain.

RSI1/FLD and its epigenetic target RRTF1 are essential for the retention of infection memory in Arabidopsis thaliana.

Plants can retain a memory of previous pathogen infections to mount a more robust defense response during subsequent infections by developing systemic acquired resistance (SAR). However, the mechanism through which plants develop and retain infection memory is not known. Experiments have shown the association of epigenetic modifications of specific defense-related genes with SAR.

Insulinoma: Presenting as hypoglycemia in a non-diabetic patient: A rare case report.

PNETs (pancreatic neuroendocrine tumors) are a rare sub-type of pancreatic tumors, with the majority of them being insulinomas. The vast majority of insulinomas (90%) are benign and solitary, with only 10% being malignant. It has a wide range of clinical manifestations and requires a high level of suspicion to diagnose.

An audit to estimate the quality of practices followed during bedside blood transfusion in a tertiary care hospital and role of continuous medical education in it.

Blood transfusion is an integral component of the health Service system and it becomes imperative that its benefits, risks as well as prospective and viable alternatives of this common medical intervention are explained explicitly to the patients. Appropriate compliance to bedside blood transfusion practices can also help in avoiding adverse transfusion outcomes. At the same time, it is also crucial to document a patient's valid consent based on their decision after evaluation of the risk to benefit ratio.

A pilot study on impact of use of medium molecular weight hydroxyethyl starch in granulocyte apheresis using Spectra Optia.

Introduction: Granulocyte transfusion (GT) is a therapeutic option for prolonged neutropenic patients with severe bacterial or fungal infections. Efficient apheresis based granulocyte collection may be better achieved by infusion of high-molecular-weight (HMW) hydroxyethyl starch (HES). But multiple adverse incidents have been reported with HMW-HES.

Toxic epidermal necrolysis-like presentation of toxic erythema of chemotherapy.

Toxic erythema of chemotherapy is an umbrella term encompassing a range of reactions characterized by symmetric erythematous to dusky patches, which can develop oedema, desquamation and/or purpura. We describe an elderly patient with prostate cancer who developed this complication while receiving docetaxel chemotherapy, presenting with prominent mucosal and periorificial involvement, along with epidermal necrosis, closely mimicking toxic epidermal necrolysis.