Endothelial Dysfunction in Children with Frequently Relapsing and Steroid-Dependent Nephrotic Syndrome.

Background: Children with frequently relapsing (FR) or steroid-dependent (SD) nephrotic syndrome (NS) show endothelial dysfunction and risk of endothelial injury during relapses, increasing the risk of accelerated atherosclerosis and adverse cardiovascular events. This study examines the plasma levels of markers of endothelial dysfunction [sE-selectin and vascular cell adhesion molecule-1 (VCAM-1)] in children aged 1-16 years with FRNS and SDNS in relapse.

Materials And Methods: Fifty-six children with FRNS and SDNS between 1 and 16 years were enrolled at the time of relapse and followed till six weeks of steroid-induced remission.

Single staged bilateral total hip replacement and its outcomes: A cross-sectional study.

Background: Bilateral hip disorder is a common finding that can occur in approximately 42% of the population with osteoarthritis. It is estimated that 25% individuals with osteoarthritis requiring total hip replacement (THR) may require a bilateral replacement. This has resulted in the test of the greatest strategy to run single staged bilateral hip replacement while addressing the outcomes to achieve swift and cost-effective patient recovery.

Predictive assessment with outcomes of phrenic nerve study in Guillain-Barré syndrome: a prospective study.

Background: Guillain-Barré syndrome (GBS) is an acute acquired autoimmune inflammatory disorder of the peripheral nerves and roots. Respiratory insufficiency is an important predictor of a poor prognosis in patients with GBS. Phrenic nerve assessment is an area of interest in GBS with respiratory failure.

A Clinico-Immunological Perspective of Paradoxical Reaction in HIV-ve Tuberculous Meningitis with Therapeutic Possibilities.

Tuberculous meningitis (TBM) is a critical form of tuberculosis with high morbidity and mortality. Paradoxical reactions (PR) are frequently observed in neurotuberculosis, with diverse manifestations. A selective immune dys/upregulation leads to cytokine surge.

Solar-driven photocatalytic system for CO fixation and conversion of dopamine into indole derivative.

Photocatalytic CO₂ fixation into solar fuels offers a promising route for renewable energy storage by converting CO₂ into chemical bonds. Among various products, formic acid is considered the most reliable candidate for industrial applications due to its high efficiency and sustainable feasibility. Various catalysts, including metals, chalcogenides, transition metals, and carbon-based materials, have been explored for this purpose.

Chikungunya and Dengue Encephalitis: A Critical Narrative Review.

Viral encephalitis is one of the leading presenting features of neurologic emergencies in tropical and subtropical areas. Chikungunya encephalitis (CE) and dengue encephalitis (DE) are important neurologic disorders of the central nervous system (CNS) with increased morbidity and mortality. This review discusses the pathogenesis, clinical features, diagnostic workup, and management of CE and DE, and provides insights into the vector-borne diseases with the help of literature obtained from clinical studies, reviews, and case series/reports.

Impact of perilesional edema on severity of migraine in patients with calcified neurocysticercosis: A prospective evaluation.

Objectives: Recent research has sparked increasing interest in the role of neuroinflammation in the pathogenesis of migraine. We hypothesize that perilesional edema, an imaging marker of inflammation caused by an immune response in the brain parenchyma surrounding calcified neurocysticercosis (NCC), may influence migraine pathophysiology. This study was designed to explore the potential impact of perilesional edema on migraine severity and treatment response.

Expanding the scope of emergency care: The clinical forensic medicine fellowship at Kings County Hospital.

Background: Most victims of trauma and abuse will seek care in an emergency department (ED) within hours of their violence-related injuries. Medical training has produced well-trained physicians to evaluate, stabilize, and treat these patients in the acute setting. Unfortunately, in an ED without forensic staff, lack of timely forensic care can result in delays in treatment, loss of evidence, and hope of any justice being achieved.

Caprine dermal scaffolds for repair of full-thickness skin wounds in rabbits.

Biological scaffolds prepared after decellularization are used for the restoration of damaged tissues. A number of chemicals are used for bioscaffold preparation, and some of them damage their composition and architecture. Herein, we investigated the Sapindus mukorossi fruit pericarp extract (SPE) (5%) for decellularization of the caprine dermis.

An observational study to determine the role of indirect immunofluorescence and ELISA for desmogleins in the diagnosis and monitoring of autoimmune bullous disorders.

Background: Autoimmune bullous disorder (AIBD) is a diverse group of blistering dermatoses that affects the skin and mucous membrane, characterized by the formation of autoantibodies against the desmosomal glycoproteins and adhesion molecular components of the basement membrane zone. Various immunoassay techniques for serological diagnosis are Direct Immunofluorescence (DIF), Indirect Immunofluorescence (IIF), Enzyme Linked Immunosorbent Assay (ELISA) and immunoblotting. Quantitative ELISA titer can also be used to monitor the disease activity and response to treatment.

Wilson's disease manifesting as refractory rickets.

Wilson's disease is a metabolic disorder affecting the liver, brain, skin and osteo-muscular organs. Refractory rickets is an unusual phenomenon in Wilson's disease. This 27-year-old man was primarily treated for rickets for 20 years without success and later developed features of tremulousness of limbs and dysphonia when he was evaluated for Wilson's disease.

as an emerging rare cause of septicemia among neonates and children in Western Uttar Pradesh: A case series.

Background And Purpose: is a recently emerging nosocomial fungal pathogen. Candidemia is the fourth most prevalent cause of bloodstream Infections with mortality rates varying from 5-71%.

Materials And Methods: This was a retrospective study conducted at Uttar Pradesh University of Medical Sciences, Etawah, India, from September 2023 to February 2024.

Evaluation of biofilm formation and carbapenem resistance in isolated from clinical samples at a rural hospital in western Uttar Pradesh.

Introduction: commonly causes healthcare-associated infections and shows multidrug resistance. can produce biofilm. Carbapenem resistance in is due to the production of carbapenemases mainly.

Colours of India: Uniting Endocrinologists in Fitness and Friendship.

Colours of India is an annual cultural phenomenon that transcends the boundaries of professional conferences, uniting endocrinologists through the universal language of music and dance. Since its inception in 2016, this vibrant event has brought together teams from across India and other participating countries, showcasing diverse dance forms while fostering friendships, promoting wellness, and celebrating cultural diversity within the medical community.

Prognostic Model to Predict Outcome of Adult Patients with Tuberculous Meningitis Undergoing Ventriculoperitoneal Shunt Surgery: A Prospective Observational Study.

Background: The prognosis of adult patients with tuberculous meningitis undergoing ventriculoperitoneal (VP) surgery is not well known. Prognostic models developed to predict the prognosis might help clinicians immensely.

Methods: This was a prospective study.

Thrombocytopenia as a Prognostic Marker in Patients with Acute Encephalitis at a Tertiary Care Center in Northern India.

Background: Acute encephalitis (AE) is associated with a high burden of mortality and permanent disability and has a spectrum of underlying etiologies. The prognosis of encephalitis is difficult and almost all the patients seem to be at a high risk of poor outcomes. A number of physiological changes take place during encephalitis and have been evaluated for their prognostic value.

A dual-stage high-gain converter with dual inputs and dual outputs for electric vehicle charging.

The DC-DC converter is an essential subsystem in electric vehicle (EV) chargers, and most converters depend on a single-input single-output structure, which can be costly when multiple charging units are needed. Additionally, these converters offer limited voltage gain, restricting charging configurations. This paper proposed a dual-stage high-gain converter that operates in a boost mode with reduced components, using an inductor, capacitor, and 2-diodes (LC2D) to provide high-gain output.

Atypical Hydatid Cyst of Entire Right Femur with Pathological Fracture: Total Femur Replacement Case Report.

Introduction: Hydatid disease is uncommon in Humans. It rarely affects the bones and joints (0.5-4%).

-a potential bioresource for the management of (Lepidoptera: Noctuidae).

Fall armyworm (FAW), (J.E. Smith), a threat to maize production systems, is a polyphagous pest of global significance.

Parkinsonism Associated with Snakebite.

Snakebites are a major cause of morbidity and mortality worldwide. Snake envenomation can cause acute local and systemic effects leading to severe complications, even death. Neurological complications such as intracranial hemorrhage, subarachnoid bleed, ischemic strokes, acute disseminated encephalomyelitis, and leukoencephalopathy have been reported.

Lidocaine patch for treatment of acute localized pain in the emergency department: a systematic review and meta-analysis.

Lidocaine patches are commonly prescribed for acute localized pain. Most of the existing evidence is, however, derived from postoperative or chronic pain. The objective of this study is to assess the efficacy and safety of lidocaine patch compared to placebo patch or nonsteroidal anti-inflammatory drugs (NSAIDs) for acute localized pain.

Interventions to improve emergency department throughput and care delivery indicators: A systematic review and meta-analysis.

Background: Emergency department (ED) crowding has repercussions on acute care, contributing to prolonged wait times, length of stay, and left without being seen (LWBS). These indicators are regarded as systemic shortcomings, reflecting a failure to provide equitable and accessible acute care. The objective was to evaluate the effectiveness of interventions aimed at improving ED care delivery indicators.

Characterization of Fowlpox Virus.

The complex cytoplasmic DNA virus known as the fowlpox virus (FWPV) is a member of the avipoxvirus genus, Subfamily Chordopoxvirinae, and Family Poxviridae. The large genome size of FWPV makes it a potential vector for the creation of vaccines against a range of serious veterinary and human ailments. It also allows for multiple gene insertion and the generation of abortive infection in mammalian cells.