The tRNA editing complex ADAT2/3 promotes cancer cell growth and codon-biased mRNA translation.

Transfer RNAs (tRNAs) are subject to various chemical modifications that influence their stability or function. Adenosine to Inosine (A-to-I) editing in the tRNA anticodon at position A34 is an important modification that expands anticodon-codon recognition at the wobble position and is required for normal mRNA translation. The relevance of tRNA editing in cancer remains unexplored.

Computed Tomographic Angiography and Yield for Gastrointestinal Bleeding in the Emergency Department.

Importance: Overuse of advanced imaging in the emergency department (ED) contributes to higher costs, reduced efficiency, and crowding. Computed tomographic angiography (CTA) is a recommended first-line diagnostic for acute gastrointestinal bleeding (GIB), yet its increasing use may not always improve detection of active bleeding.

Objective: To evaluate recent trends in CTA use for suspected GIB in the ED and assess changes in diagnostic yield.

Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.

Introduction: Microplastics (MPs) and nanoplastics (NPs) are pervasive environmental contaminants with growing concerns about their ingestion through food and water sources. Although animal studies suggest adverse health effects, direct mechanistic evidence in human gastrointestinal (GI) systems remains limited. In vitro models using human GI cell lines and organoids offer a physiologically relevant platform for investigating the effects of MPs and NPs on human health.

Intravenous Versus Subcutaneous Tranexamic Acid in Liposuction: A Comparative Analysis of Efficacy and Safety.

Background: Liposuction is among the most carried-out aesthetic procedures in the world and is usually associated with considerable intraoperative blood loss. Tranexamic acid is an antifibrinolytic agent commonly used to minimize blood loss during surgery. However, there is scant evidence regarding the comparative efficacy and safety of intravenous administration versus subcutaneous administration during liposuction.

Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases.

Background: Mucosal histological activity is increasingly valued as a treatment endpoint in inflammatory bowel diseases (IBD). In the Asia Pacific region, the utility and acceptability of IBD histology as a treatment endpoint are uncertain due to the heterogeneity of IBD prevalence, resourcing and level of knowledge among practitioners. There is an opportunity to engage clinicians to harmonise histology reporting and collaborate with pathologists in this field.

Impact of microplastics on the human gut microbiome: a systematic review of microbial composition, diversity, and metabolic disruptions.

Global plastic waste production remains a critical environmental issue. Microplastics (MPs), plastic particles less than 5 mm, are now pervasive across ecosystems. Humans are exposed to MPs via ingestion, inhalation, and dermal contact raising concerns about their health impacts.

Experience Sampling to Assess Burnout in Emergency Medicine: An Acceptability and Feasibility Pilot.

Introduction: Despite prior efforts to improve well-being in emergency medicine, clinician burnout in the specialty is rising. In this study we examined the acceptability and feasibility of using a method called "experience sampling" to explore factors important to clinician experience in emergency departments (ED). Experience sampling enables the measuring of work experience in real time, with more granular detail than in usual burnout surveys.

Assessment of 3 standards-based clinical decision support (CDS) tools in an academic electronic health record using Clinical Quality Language, CDS Hooks, and Fast Healthcare Interoperability Resources: a retrospective evaluation.

Objectives: To evaluate clinical decision support (CDS) of varying complexities and care settings represented using Health Information Technology (HIT) standards-Clinical Quality Language (CQL) for representing clinical logic and Fast Healthcare Interoperability Resources (FHIR) for health information exchange.

Materials And Methods: This Institutional Review Board-approved, retrospective study was performed at an academic medical center (January 1, 2023-December 31, 2023). Recommendations extracted from patient-centered outcomes guidelines were translated into standardized syntax (SNOMED CT) and representations (CQL, FHIR).

Climate-Smart Diagnostic Medical Imaging and Point-of-Care Ultrasound: An Evidence-Based Perspective.

Background: Hospital diagnostic imaging significantly contributes to healthcare's carbon emissions, with modalities such as magnetic resonance imaging (MRI) and computed tomography (CT), accounting for a disproportionate share of energy consumption and greenhouse gas (GHG) emissions. While clinical value remains paramount, sustainability must become part of imaging decision-making.

Objectives: Point-of-care ultrasound (POCUS) is known for its portability, cost-effectiveness, and bedside efficiency, but its environmental impact remain underexplored.

Key findings from multisite implementation of electronic health record tools for clinical pretest probability of pulmonary embolism in the emergency department.

Background: The use of validated risk stratification tools for the workup of suspected pulmonary embolism (PE) is a recommendation of the American Society of Hematology and the American College of Emergency Physicians.

Methods: We designed and implemented electronic clinical pretest probability (PTP) tools for use in emergency departments (ED). Overall, 38 EDs (tertiary and regional EDs) in the United States were involved across three health systems.

Examining the perception of undergraduate pharmacy students towards their leadership competencies: a mixed-methods study.

Background: Leadership development is crucial for pharmacy students to meet the evolving demands of healthcare. However, research on pharmacy students' perceptions of their leadership competencies and development opportunities remains limited. This study explores students' perceptions at the College of Pharmacy at Qatar University (CPH-QU), regarding their leadership knowledge, skills, attitudes, and available opportunities for leadership development.

Cumulative Effect of Targeted Interventions on Radiologist Recommendations for Additional Imaging.

Background Ambiguous or unnecessary radiologist recommendations for additional imaging (RAIs) can lead to excessive imaging use and diagnostic errors. Purpose To determine the cumulative impacts of multifaceted technology-enabled interventions aimed at optimizing RAI on RAI rate, actionability, and resolution over an 8-year period. Materials and Methods In this retrospective cohort study, conducted from January 2015 to December 2022, radiology reports from two tertiary hospitals (study site and control site) were analyzed.

Effects of Yogurt Enriched with Konjac Glucomannan and Inulin on Insulin Sensitivity, Glycemic Control, Lipid Profiles, Anthropometric Measures and Oxidative Stress in Type 2 Diabetes Mellitus: A Randomized Controlled Trial.

Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disorder that requires effective dietary strategies for management. In this randomized, double-blind, placebo-controlled clinical trial, the effects of low-fat yogurt enriched with konjac glucomannan (KGM) and inulin on glycemic control, lipid profiles, anthropometric indices, and oxidative stress were investigated in patients with T2DM. Eighty participants were randomly assigned to consume either 150 g of yogurt enriched with 1.

Global evolution of inflammatory bowel disease across epidemiologic stages.

During the twentieth century, inflammatory bowel disease (IBD) was considered a disease of early industrialized regions in North America, Europe and Oceania. At the turn of the twenty-first century, IBD incidence increased in newly industrialized and emerging regions in Africa, Asia and Latin America, while the prevalence in early industrialized regions continued to grow steadily. Changes in the incidence and prevalence denote the evolution of IBD across four epidemiologic stages: stage 1 (emergence), characterized by low incidence and prevalence; stage 2 (acceleration in incidence), marked by rapidly rising incidence and low prevalence; and stage 3 (compounding prevalence), where the incidence decelerates, plateaus or declines while the prevalence steadily increases.

The GALAD score performs better than AFP in hepatocellular carcinoma screening: a single-centre, case-control study in Malaysia.

Aim Of The Study: Hepatocellular carcinoma (HCC) in Malaysia is a growing health concern, despite regular liver ultrasound and α-fetoprotein (AFP) surveillance. The GALAD model incorporates AFP, lens culinaris agglutinin- reactive α-fetoprotein (AFP-L3), protein induced by vitamin K antagonist-II (PIVKA-II), gender and age to predict the probability of HCC. Our objective was to evaluate the diagnostic ability of GALAD compared to AFP in HCC screening.

Development and validation of the discharge severity index for post-emergency department hospital readmissions.

Introduction: Hospital readmissions often result from a combination of factors, including inadequate follow-up care, poor discharge planning, patient non-adherence, and social determinants of health (SDOH) that impact access to healthcare and follow-up resources, many of which are beyond provider control. Enhanced post-discharge strategies, including risk stratification, are essential. This study aims to develop and validate the Discharge Severity Index (DSI) to predict readmission risk and optimize resource allocation for effective follow-up care.

Psychometric properties of a questionnaire assessing the extent of integration in a problem-based learning curriculum.

Background: Integrated curricula reinforce student learning and retention of relevant knowledge. At Qatar University and Arabian Gulf University medical colleges, Problem-Based Learning (PBL) is the principal teaching and learning strategy to implement integrated multidisciplinary system-based curriculum. In addition, other initiatives include integrated assessment, logical organization of teaching and learning methods, as well as combined faculty effort in curriculum planning and delivery.

Two-year Results of an Emergency Department Night Shift Buy-out Program.

Introduction: Emergency physicians have the highest rates of burnout among our physician peers, with prior literature suggesting clinician schedules can play a significant role in burnout. We assessed our transition from a tenure- and age-based paradigm to an egalitarian, night shift buy-out program that allows schedule flexibility for physicians at all stages of their careers.

Methods: The night shift buy-out program was implemented in the emergency department (ED) of an academic, quaternary-care center that treats approximately 100,000 adult patients annually with 56 faculty emergency physicians.

Evaluating Billing Code Distributions in the Emergency Department Following the Implementation of the New Documentation Guidelines.

Objectives: Changes to the Current Procedural Terminology (CPT) evaluation and management (E/M) documentation guidelines implemented on January 1, 2023, were primarily meant to address dissatisfaction with the prior system; however, it was not known how the changes might alter billing distributions. In this study, we compare the proportion of visits for each E/M code before and after the enactment of the changes across 5 emergency departments (EDs) to determine the effects on billing.

Methods: This was a retrospective, observational analysis of all ED visits for patients over 18 years across 5 EDs from January 1 to March 31 in the years 2021, 2022, and 2023.

A methyltransferase-independent role for METTL1 in tRNA aminoacylation and oncogenic transformation.

Amplification of chromosomal material derived from 12q13-15 is common in human cancer and believed to result in overexpression of multiple collaborating oncogenes. To define the oncogenes involved, we overexpressed genes recurrently amplified in human liposarcoma using a zebrafish model of the disease. We found several genes whose overexpression collaborated with AKT in sarcomagenesis, including the tRNA methyltransferase METTL1.

APAGE Position Statements on Green and Sustainability in Gastroenterology, Hepatology, and Gastrointestinal Endoscopy.

Background And Aim: The APAGE Position Statements aimed to provide guidance to healthcare practitioners on clinical practices aligned with climate sustainability.

Methods: A taskforce convened by APAGE proposed provisional statements. Twenty-two gastroenterologists from the Asian Pacific region participated in online voting and consensus was assessed through an anonymized and iterative Delphi process.

Subphenotypes of Long COVID and the clinical applications of probiotics.

As the number of infections and deaths attributable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to rise, it is now becoming apparent that the health impacts of the Coronavirus disease (COVID-19) may not be limited to infection and the subsequent resolution of symptoms. Reports have shown that patients with SARS-CoV-2 infection may experience multiple symptoms across different organ systems that are associated with adverse health outcomes and develop new cardiac, renal, respiratory, musculoskeletal, and nervous conditions, a condition known as Long COVID or the post-acute sequelae of COVID-19 (PASC). This review provides insights into distinct subphenotypes of Long COVID and identifies microbiota dysbiosis as a common theme and crucial target for future therapies.

Trend of Representation of Women in Gastroenterology, Hepatology, and Endoscopy Conferences in Asia.

Objectives: Despite progress in promoting gender equality, gender bias remains a significant obstacle for women and hinders their academic advancement. We aim to survey and critically analyze women's representation in conferences and changes over time in various regions of Asian countries.

Methods: An international survey was conducted with representatives from East Asia (Hong Kong, China, and Japan), South Asia (India and Pakistan), and Southeast Asia (Vietnam and Thailand).