Updated global distribution of Plasmodium vivax circumsporozoite protein variants and their correlation with vector susceptibility: A systematic review and meta-analysis.

The global distribution of Plasmodium vivax Circumsporozoite Protein variants (PvCSP), VK210, VK247, and P. vivax-like, plays a crucial role in malaria transmission and vaccine development. This systematic review and meta-analysis assessed the prevalence of these variants in humans and their association with Anopheles species worldwide.

Efficacy of Stereotactic Ablative Body Radiotherapy (SABR) in uncommon subtypes of primary kidney cancer: An analysis from the International Radiosurgery Oncology Consortium of the Kidney.

Background: While stereotactic ablative body radiotherapy (SABR) is associated with excellent local control for primary renal cell carcinoma (RCC), outcomes based on clear-cell (ccRCC) and non-clear cell (nccRCC) histologies are not well defined.

Methods And Materials: Individual data of adult patient with biopsy confirmed primary RCC receiving SABR between 2007 and 2021 from 16 institutions in Australia, Canda, Germany, Japan and USA pooled. Patients with metastatic disease or upper tract urothelial carcinoma were excluded.

The role of Cacao agroforests in the genetic conservation of Cariniana legalis, an emblematic species of the atlantic forest.

Deforestation in the Atlantic Forest has reached critical levels, threatening multiple levels of biodiversity. In these deforested landscapes, conservation strategies could benefit from preserving agroforestry systems known as Cabruca, a traditional method of cultivating cocoa under a canopy of native trees. In this context, Cariniana legalis (Jequitibá-rosa), an endemic tree species of the Atlantic Forest listed as endangered, was selected to evaluate the role of cocoa agroforests (Cabrucas) and forest remnants in the genetic conservation of this species.

Insights into the Structural Patterns in Human Glioblastoma Cell Line SF268 Activity and ADMET Prediction of Curcumin Derivatives.

: Curcumin is a promising therapy for glioblastoma but is limited by poor water solubility, rapid metabolism, and low blood-brain barrier penetration. This study aimed to evaluate curcumin and six curcumin derivatives with improved activity against a glioblastoma cell line and favorable absorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. : Twenty-one curcumin derivatives were assessed and subjected to in vitro MTT cytotoxicity assays in SF268 glioblastoma and Vero cells.

Influence of physical exercise on health improvement in older adult cancer patients: a systematic review.

Introduction: Physical exercise has shown evidence in the recovery of cancer treatment. Therefore, interventions that influence these patients to adhere to physical exercise may prove beneficial. This study aimed to identify the influence of physical exercise on health improvement in older adult cancer patients.