Aberrant recursive splicing in a human disease locus.

Recursive splice sites are rare motifs postulated to facilitate splicing across massive introns and shape isoform diversity, especially for long, brain-expressed genes. The necessity of this unique mechanism remains unsubstantiated, as does the role of recursive splicing (RS) in human disease. From analyses of rare copy number variants (CNVs) from almost one million individuals, we previously identified large, heterozygous deletions eliminating an RS site (RS1) in the first intron of that conferred substantial risk for attention deficit hyperactivity disorder (ADHD) and other neurobehavioral traits.

Older Subjects Admitted to Hospital With Stroke From Long-Term Care: A National Cohort and Case Control Study.

Objectives: Internationally about 3% of people ≥65 years live in long-term care (LTC) settings. Older people living in nursing homes are more likely to be admitted to hospital. We examined the characteristics and outcomes of stroke patients admitted from LTC nationally and how this changed over the COVID-19 pandemic.

Associations between fishes (Actinopterygii: Teleostei) and anthozoans (Anthozoa: Hexacorallia) in epipelagic waters based on in situ records.

We formally describe the association of fishes and anthozoans in epipelagic waters, extending this relationship to beyond the benthos. In situ observations and photographs of Aluterus schoepfii, Ariomma regulus, Caranx cf. latus and Brama spp.

The Impact of Financial Incentives on Completion of a No Money No Time 6-Week Culinary Nutrition eHealth Challenge.

Introduction: No Money No Time is a culinary nutrition website focused on diet quality improvement. The aim was to compare participant retention in a 6-week eHealth challenge, with and without use of financial incentives and to compare demographic characteristic, diet quality and engagement outcomes between them.

Methods: The single-arm, pre-post studies [Spring Eatz (30 August to 17 September, 2023) and RE$ET (20th February to March, 2024)] recruited adults ≥ 18 years from Australia into a 6-week nutrition challenge delivered via weekly emails that directed participants to the No Money No Time (NMNT) purpose-built culinary and nutrition-related health website from after completing the embedded Healthy Eating Quiz (HEQ) and consenting to data use for research purposes.

Evaluating early coparenting using the Lausanne Trilogue Play observational procedure: Guidance for infant-family practitioners from an International Coparenting Collaborative.

Since the early 1990s, coparenting - a conceptual framework connecting clinical insights from structural family therapy to theory and research on development of infants and toddlers within relationship systems - has brought new perspective to family and developmental science while hinting at ramifications for clinical practice. Coparenting theory and research evolved side-by-side with careful, intensive study of mother-father-child triangular relationships in families with very young children, work that expanded in recent years to include studies of other coparent-child triangular systems, such as those involving mothers, grandmothers, and infants. Until now, however, there has been no coordinated expert guidance for bringing concepts expounded in research studies of coparenting and triangular relationships to practitioners who work in infant-family mental health and family therapy contexts.