Physiologically Based Pharmacokinetic Modeling of Vancomycin and its Comparison with Population Pharmacokinetic Model in Neonates.

Vancomycin has a narrow therapeutic window and a high inter-individual pharmacokinetic variability, especially in neonates with fast maturational and pathophysiological changes, that needs individualized dosing. Physiologically based pharmacokinetic (PBPK) model and population pharmacokinetic (PopPK) model are both useful tools in model-informed precision dosing, while the former is under research in application of vancomycin in neonates. This study aimed to develop a PBPK model of vancomycin in adult and pediatric population, and compared it with published PopPK model (priori or Bayesian method) in predicting vancomycin concentration in 230 neonatal patients (postmenstrual age, PMA, 25-45 weeks).

Physiologically-Based Pharmacokinetic Modeling and Dosing Optimization of Cefotaxime in Preterm and Term Neonates.

Background: Cefotaxime is commonly used in treating bacterial infections in neonates. To characterize the pharmacokinetic process in neonates and evaluate different recommended dosing schedules of cefotaxime, a physiologically-based pharmacokinetic (PBPK) model of cefotaxime was established in adults and scaled to neonates.

Methods: A whole-body PBPK model was built in PK-SIM® software.

A Cationic Octanuclear Zirconium Peroxide Ring with Unusual Thermal Stability.

Studies about the reaction of Zr ions with peroxides and the properties of the resulting zirconium peroxide clusters are significant for understanding zirconium chemistry in the nuclear fuel cycle and the advancement of less explored Group IV metal oxo clusters. Herein, an octanuclear zirconium peroxide cluster, designated as Zr, was synthesized and characterized by using multiple techniques. Crystallographic analysis revealed that Zr has a ringlike structure and unusual positive charges, while tetravalent metal oxo clusters are mostly neutral.

μPESI-MS/MS System for Screening and Quantitating Drugs in Plasma Samples.

Recently, we developed a novel microprobe electrospray ionization (μPESI) source and its coupled MS (μPESI-MS/MS) system. Here, we aimed to widely validate the μPESI-MS/MS method for quantitative analysis of drugs in plasma samples. Furthermore, the relationship between the quantitative performance of the μPESI-MS/MS method and the physicochemical properties of target drugs was analyzed.

Development, validation and application of a UHPLC-MS/MS method for quantification of the adiponectin-derived active peptide ADP355 in rat plasma.

A UHPLC-MS/MS method for the quantification of ADP355, an adiponectin-derived active peptide, was developed and validated. The extraction method employed simple protein precipitation using methanol and chromatographic separation was achieved on anAccucore™ RP-MS C column (100 × 2.1 mm, 2.

Tissue-Adaptive Materials with Independently Regulated Modulus and Transition Temperature.

The ability of living species to transition between rigid and flexible shapes represents one of their survival mechanisms, which has been adopted by various human technologies. Such transition is especially desired in medical devices as rigidity facilitates the implantation process, while flexibility and softness favor biocompatibility with surrounding tissue. Traditional thermoplastics cannot match soft tissue mechanics, while gels leach into the body and alter their properties over time.

Signal Drift in Liquid Chromatography Tandem Mass Spectrometry and Its Internal Standard Calibration Strategy for Quantitative Analysis.

The present project studied the signal drift in liquid chromatography tandem mass spectrometry (LC-MS/MS) and proposed a strategy for compensating such drift. In the study, four 4-component groups were repeatedly run on different LC-MS/MS systems for over 12 h to investigate the dependence of signal drift on time and hardware systems. The 4-component groups each consisted of (1) an analyte, (2) a stable isotope labeled analyte, (3) a compound with similar structure to the analyte, and (4) a compound with dissimilar structure.

Universal Coatings Based on Zwitterionic-Dopamine Copolymer Microgels.

Multifunctional coatings that adhere to chemically distinct substrates are vital in many industries, including automotive, aerospace, shipbuilding, construction, petrochemical, biomedical, and pharmaceutical. We design well-defined, nearly monodisperse microgels that integrate hydrophobic dopamine methacrylamide monomers and hydrophilic zwitterionic monomers. The dopamine functionalities operate as both intraparticle cross-linkers and interfacial binders, respectively providing mechanical strength of the coatings and their strong adhesion to different substrates.

Bottlebrush Elastomers: A New Platform for Freestanding Electroactuation.

Freestanding, single-component dielectric actuators are designed based on bottlebrush elastomers that enable giant reversible strokes at relatively low electric fields and altogether avoid preactuation mechanical manipulation. This materials design platform allows for independent tuning of actuator rigidity and elasticity over broad ranges without changing chemical composition, which opens new opportunities in soft-matter robotics.

Weak Hydrogen Bonding Enables Hard, Strong, Tough, and Elastic Hydrogels.

A new type of "rigid and tough" hydrogel with excellent elasticity is designed by dense clustering of hydrogen bonds within a loose chemical network. The resultant hydrogel exhibits a good combination of high modulus (28 MPa), toughness (9300 J m(-3) ), extensibility (800%), and tensile stress (2 MPa). Furthermore, the gel displays good fatigue-resistance and complete and extremely fast recovery of shape and mechanical properties (3 min at 37°C).

Dynamic Optical Gratings Accessed by Reversible Shape Memory.

Shape memory polymers (SMPs) have been shown to accurately replicate photonic structures that produce tunable optical responses, but in practice, these responses are limited by the irreversibility of conventional shape memory processes. Here, we report the intensity modulation of a diffraction grating utilizing two-way reversible shape changes. Reversible shifting of the grating height was accomplished through partial melting and recrystallization of semicrystalline poly(octylene adipate).

Exploring quality in gradient copolymers.

Quality of gradient copolymers is evaluated by atomic force microscopy (AFM) and correlated with molecular weight distribution (MWD) values. ARGET ATRP is employed with decreasing levels of catalyst concentrations to generate copolymers with increasing M¯w/M¯n values. The copolymers are transformed into molecular bottlebrushes to enable imaging and analysis of individual molecules by AFM.