Metabolic and bariatric surgery reduces aging biomarkers in patients with obesity, independently of achieving optimal total weight loss.

Introduction: Obesity, a chronic disease linked to premature aging, is increasingly managed through metabolic and bariatric surgery (MBS).

Aim: This study aimed to evaluate whether changes in biological age markers depended on the optimal weight loss rates resulting from MBS.

Materials And Methods: In this prospective, observational study, 100 patients with obesity scheduled for MBS from July 2020 to May 2021 underwent a 24-month postoperative follow-up.

The impact of metabolic bariatric surgery on biological markers of aging: a 2-year prospective observational study.

Background: Obesity-related proinflammatory mechanisms and genetic instability accelerate aging mechanisms. The effects of metabolic bariatric surgery (MBS) on premature aging remain unclear.

Objectives: This study aimed to assess the impact of MBS on premature aging.

What Is the Impact of Obesity-Related Comorbidities on the Risk of Premature Aging in Patients with Severe Obesity?: A Cross-Sectional Study.

: The relationships between aging, chronic diseases, and obesity remain complex and poorly understood. This study aimed to investigate the impact of comorbidities on premature aging in individuals with severe obesity. : This cross-sectional study included 99 bariatric patients with severe obesity (SG) and 30 healthy volunteers (HC).

Changes in Circulating Adipokine Levels in COVID-19 Patients.

: The COVID-19 pandemic has posed significant global health challenges. Despite extensive research efforts, the inflammatory response triggered by SARS-CoV-2 remains to be further explored and understood. Our study aims to examine the changes in serum concentrations of pro-inflammatory adipokines-visfatin and leptin-in COVID-19 patients in relation to a healthy control group.

Total versus partial adrenalectomy in bilateral pheochromocytoma - a systematic review and meta-analysis.

Background: In patients with bilateral pheochromocytoma, partial adrenalectomy offers the chance to preserve adrenal function and avoid the need for lifelong steroid supplementation. However, the risk of tumour recurrence raises questions about this procedure. The aim of our study was to compare partial and total adrenalectomy in bilateral pheochromocytoma through a systematic review with meta-analysis.

Modified Frailty Index and Brief Geriatric Assessment does not predict prolonged hospitalization in elderly patients undergoing appendectomy due to Acute Appendicitis.

Introduction: Epidemiology and the outcomes of acute appendicitis in elderly people are very different from the younger patients. Aim of this study was to investigate the significance of frailty syndrome in the course of acute appendicitis.

Methods: All patients over 65 years old who underwent laparoscopic appendectomy between 2013 and 2021 in 2nd Department of General Surgery were included in the study.

Radiological Features for Frailty Assessment in Patients Requiring Emergency Laparotomy.

Introduction: As the number of elderly patients requiring surgical intervention rises, it is believed that frailty syndrome has a greater impact on perioperative course than on chronological age. The aim of this study was to evaluate the efficacy of various imaging features for frailty assessment in patients undergoing emergency laparotomy.

Methods: The study included all patients that qualified for emergency surgery with preoperative CT scans between 2016 and 2020 in the Second Department of General Surgery.

Quality of Life After Bariatric Surgery-a Systematic Review with Bayesian Network Meta-analysis.

Objective: Comprehensive analysis and comparison of HRQoL following different bariatric interventions through systematic review with network meta-analysis.

Background: Different types of bariatric surgeries have been developed throughout the years. Apart from weight loss and comorbidities remission, improvement of health-related quality of life (HRQoL) is an important outcome of metabolic surgery.

Thyroidectomy: is it safe to be performed by general surgery residents? - single centre experience.

Background: Thyroidectomy carries a risk of two crucial complications - recurrent nerve palsy and hypocalcaemia. The aim of the study was to assess the safety of thyroidectomy performed by general surgery residents.

Methods: Data of 515 patients, who underwent total thyroidectomy between the years 2015 and 2019, were prospectively collected.

Postoperative Olfaction Alteration Following Laparoscopic Bariatric Surgery.

Introduction: Bariatric surgery is an effective method of treatment for morbid obesity that is known to change nutritional habits. Proper nutrition has an impact on postoperative recovery and outcomes. Diet preferences depend on flavour and olfaction stimuli.

TILLUS-A Rich and Renewable Source of Induced Mutations for Forward/Reverse Genetics and Pre-breeding Programs in Barley ( L.).

TILLING (Targeting Induced Local Lesions IN Genomes) is a strategy used for functional analysis of genes that combines the classical mutagenesis and a rapid, high-throughput identification of mutations within a gene of interest. TILLING has been initially developed as a discovery platform for functional genomics, but soon it has become a valuable tool in development of desired alleles for crop breeding, alternative to transgenic approach. Here we present the TILLUS ( -ING-niversity of ilesia) population created for spring barley cultivar "Sebastian" after double-treatment of seeds with two chemical mutagens: sodium azide (NaN) and N-methyl-N-nitrosourea (MNU).

Identification and functional analysis of the HvD14 gene involved in strigolactone signaling in Hordeum vulgare.

In this study, the barley HvD14 gene encoding α/β hydrolase, which is involved in strigolactone (SL) signaling, was identified. Bioinformatics analysis revealed that the identified gene is an orthologue of the D14, AtD14 and PhDAD2 genes that have been described in rice, Arabidopsis thaliana and petunia, respectively. Using TILLING strategy, an hvd14.