The efficacy of early facial nerve decompression in treating severe Ramsay Hunt syndrome.

Background: The incidence of Ramsay Hunt syndrome (RHS) has significantly increased in recent years, highlighting the need to explore effective surgical treatment strategies.

Methods: A total of 12 patients with severe RHS who visited our hospital from January 2021 to March 2023 were retrospectively included. The results of neuroelectrophysiological examination of the affected and healthy sides of all patients at baseline, 1 month postoperatively, 3 months postoperatively, 6 months postoperatively, and 12 months postoperatively were counted.

ATOX1 Promotes Hepatocellular Carcinoma Carcinogenesis via Activation of the c-Myb/PI3K/AKT Signaling Pathway.

Background And Aims: Despite advancements in diagnostic and therapeutic strategies, hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality. Antioxidant-1 (ATOX1) has been implicated in oncogenic processes across various cancer types; however, its specific role in HCC remains unclear. This study aimed to investigate the function of ATOX1 and its underlying molecular mechanisms in HCC.

A common-sense model-based nursing intervention improves exercise compliance in coronary heart disease: a randomized controlled trial and a pilot study.

Aims: This study explored the effects of a Common-sense model of self-regulation-based nursing intervention on enhancing cardiac exercise rehabilitation compliance in coronary heart disease patients, aiming to improve cardiac function and overall health outcomes.

Design: This study was a two-arm, parallel prospective randomized controlled trial.

Methods: Participants were recruited from February to August 2024 at 3 Hospitals in Changsha, Hunan, China.

ATF4 regulates PI3K/AKT signaling axis to promote angiogenesis after myocardial infarction.

Effective neovascularization is critical for tissue repair and the enhancement of cardiac function following myocardial infarction (MI). However, the hypoxic microenvironment post-MI significantly impedes neovascular formation. Although ATF4 has been implicated in heart failure and myocardial cell regeneration and repair, its role in angiogenesis remains unclear.

The role and mechanism of PGC-1α in oxLDL-induced ferroptosis of vascular endothelial cells.

Ferroptosis is a regulated form of cell death that is dependent on reactive oxygen species (ROS) and iron metabolism. Ferroptosis can participate in the formation and rupture of atherosclerotic plaque by regulating apoptosis. However, the mechanism of vascular endothelial cells (VECs) ferroptosis in the occurrence and development of atherosclerosis (AS) requires further exploration.

AREG regulatory T cells mediating myocardial repair and neovascularization after myocardial infarction.

Unlabelled: Enhancing tissue repair and angiogenesis post-Acute myocardial infarction (AMI) is critical to improving cardiac function and preventing heart failure. Recent studies have highlighted the interaction between immune cells and endothelial cells in post-AMI angiogenesis, yet the specific contributions of different immune cell subsets remain poorly understood. Emerging evidence suggests the presence of a subset of regulatory T cells (Tregs) expressing Amphiregulin (AREG) in infarcted myocardial tissue, with AREG acting as a paracrine protein that plays a key role in angiogenesis.

Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation.

Aristolochic acids are herbal compound found in many traditional medicines. Among these compounds, AAI is the most frequent and the most toxic, and it could accumulate in water or soil to contaminate our foods, inducing severe toxic effects on human health. Previous research has reported AAI was involved in HCC development mainly by T > A mutation induction.

Clinical efficacy of linezolid in the treatment of tuberculous meningitis: a retrospective analysis and literature review.

Background: Tuberculous meningitis (TBM) is the most severe form of tuberculosis, with high morbidity and mortality. This retrospective study evaluates the clinical efficacy of linezolid in patients with TBM.

Methods: We analyzed 99 TBM patients treated at the Shanghai Public Health Clinical Center from June 2013 to March 2020.

Prediction of bone metastasis of prostate cancer based on intratumoral and peritumoral radiomics of MRI T2WI combined with ADC images.

Objective: To investigate the value of intratumoral and peritumoral MRI radiomic models in predicting bone metastasis of prostate cancer patients using T2WI combined with ADC images.

Materials And Method: A total of 144 patients with prostate cancer who underwent preoperative MRI (T2WI and DWI) were retrospectively included. All patients were categorized into two groups based on the presence of bone metastasis.

Role of the nucleotide excision repair function of CETN2 in the inhibition of the sensitivity of hepatocellular carcinoma cells to oxaliplatin.

Resistance to platinum-based chemotherapy agents like oxaliplatin (OXA) poses significant challenges in the treatment of cancers such as hepatocellular carcinoma (HCC). Centrin 2 (CETN2), which functions in nucleotide excision repair (NER) of DNA damage, is overexpressed in HCC. We investigated the potential role of CETN2 in modulating the sensitivity of HCC cells to OXA.

Indoor ventilation frequency and cognitive function among Chinese old adults: the multiple mediation effect of anxiety and self-rated health.

Background: China is experiencing an increasingly serious aging population. Cognitive function is an important factor and guarantee for the quality of life of older people. Therefore, to achieve healthy aging, this study aimed to examine the sequential multiple mediating effects of indoor ventilation frequency and cognitive function on anxiety and self-rated health in the Chinese older people population.

Study on the relationship between indoor ventilation frequency and anxiety and depression symptoms in older persons: based on the data of 2018 CLHLS.

Background: To investigate the association between indoor ventilation frequency and symptoms of depression and anxiety in older persons.

Methods: A binary logistic regression model was used to analyze the effects of indoor ventilation frequency on depression and anxiety by using data from the 2018 Chinese longitudinal healthy longevity survey (CLHLS).

Results: A total of 9,690 older persons with an average age of (83.

The protective roles of eugenol on type 1 diabetes mellitus through NRF2-mediated oxidative stress pathway.

Type 1 diabetes mellitus (T1DM), known as insulin-dependent diabetes mellitus, is characterized by persistent hyperglycemia resulting from damage to the pancreatic β cells and an absolute deficiency of insulin, leading to multi-organ involvement and a poor prognosis. The progression of T1DM is significantly influenced by oxidative stress and apoptosis. The natural compound eugenol (EUG) possesses anti-inflammatory, anti-oxidant, and anti-apoptotic properties.

The effect of internet use on depressive symptoms in older adults: based on the chain mediating role of physical exercise and self-rated health.

Background: Depressive symptoms in older adults have been a major public health problem. Although many studies have suggested a potential relationship between Internet use and depressive symptoms, the underlying mechanisms of this relationship among older adults remain unclear. This study aimed to explore the multiple mediating effects of physical exercise and self-rated health on the relationship between Internet use and depressive symptoms in older adults.

Physiological energetics of selectively bred oysters (Crassostrea hongkongensis) under marine heatwaves.

Marine heatwaves (MHWs) have become more frequent and intense in the context of rapid climate change, causing detrimental effects on marine bivalves and ecosystems they sustain. While selective breeding programs for bivalves can substantially enhance growth performance, their ability to improve thermal stress tolerance remains largely unexplored. Here, we compared physiological energetics of wild and selectively bred Hongkong oysters (Guihao No.

Proton-Mediated Dynamic Nestling of DNA Payloads Within Size-Matched MOFs Nanochannels for Smart Intracellular Delivery.

With sequence-programmable biological functions and excellent biocompatibility, synthetic functional DNA holds great promise for various biological applications. However, it remains a challenge to simultaneously retain their biological functions while protecting these fragile oligonucleotides from the degradation by nucleases abundant in biological circumstances. Herein, a smart delivery system for functional DNA payloads is developed based on proton-mediated dynamic nestling of cytosine-rich DNA moieties within the precisely size-matched nanochannels of highly crystalline metal-organic frameworks (MOFs): At neutral pH, cytosine-rich DNA strands exhibit a flexible single-stranded state and can be accommodated by MOFs nanochannels with a size of ca.

The function of histone methyltransferase SETDB1 and its roles in liver cancer.

Epigenetic alterations in gene expression have been implicated in cancer development and tumor immune escape, with posttranslational histone or non-histone modifications representing attractive targets for disease surveillance and therapy. SET domain bifurcated 1 (SETDB1) is a histone lysine methyltransferase that reversibly catalyzes the di- and tri-methylation of histone 3 lysine 9 (H3K9) on euchromatin, inhibiting gene transcription within these regions and facilitating the switch from euchromatic to heterochromatic states. Emerging evidence suggests that SETDB1 amplification and aberrant activation are significantly associated with poor prognosis in hepatocellular carcinoma (HCC), and contribute to HCC development, immune escape, and immune checkpoint blockade (ICB) resistance.

A Cross-Sectional Study of Risk Factors for Coronary Heart Disease in Secondary Prevention for Patients With the Disease in China.

Aims: To explore risk factors for Coronary Heart Disease (CHD) in secondary prevention for patients with the disease in China.

Design: Cross-sectional study.

Methods: A two-stage sampling method was used (stratified sampling and systematic sampling).

Seasonal dynamics of antibiotic resistance genes and mobile genetic elements in a subtropical coastal ecosystem: Implications for environmental health risks.

Antibiotic resistance poses a considerable global public health concern, leading to heightened rates of illness and mortality. However, the impact of seasonal variations and environmental factors on the health risks associated with antibiotic resistance genes (ARGs) and their assembly mechanisms is not fully understood. Based on metagenomic sequencing, this study investigated the antibiotic resistome, mobile genetic elements (MGEs), and microbiomes in a subtropical coastal ecosystem of the Beibu Gulf, China, over autumn and winter, and explored the factors influencing seasonal changes in ARG and MGE abundance and diversity.

miRNA-seq provides novel insight into the response to hyper- and hypo- salinity acclimation in Crassostrea hongkongensis.

The Hong Kong oyster, Crassostrea hongkongensis, is a significant bivalve species with economic importance. It primarily inhabits the estuarine intertidal zones in southern China, making it susceptible to salinity fluctuations. Consequently, investigating the molecular mechanisms governing salinity regulation in C.

Dual stimuli-responsive upconversion nanoparticle-poly--isopropylacrylamide/DNA core-shell microgels.

Stimuli-responsive upconversion nanoparticle (UCNP)-poly--isopropylacrylamide (pNIPAM)/DNA core-shell microgels with tunable sizes and programmable functions have been prepared. Thanks to the near-infrared (NIR)-responsive UCNP cores and thermosensitive polymeric shells, functional DNA-incorporated microgels with high DNA activity and loading efficiency are obtained, and the activity of the loaded DNA structures can be smartly regulated by NIR illumination and temperature simultaneously.